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secM

Gene
secM
Protein
Secretion monitor
Organism
Yersinia enterocolitica serotype O:8 / biotype 1B (strain NCTC 13174 / 8081)
Length
177 amino acids
Function
Regulates secA expression by translational coupling of the secM secA operon. Translational pausing at a specific Pro residue 5 residues before the end of the protein may allow disruption of a mRNA repressor helix that normally suppresses secA translation initiation.
Similarity
Belongs to the SecM family.
Mass
19.928 kDa
Sequence
MIGILNRWRQFGRRYFWPHLLLGMVAASLGVPSNLSGVPDQAAIPNTSSSQSRQNYGATNFSSLALLHDMHRRPSFSVDYWQQHALRTVIRHLSFALAPQVAYARVQEVAEAEQVQPSQIQQLALLNTLNALLTHEFKPPTIIRYTEQIKRPVLSLHKPGLWLAQVQGIRAGPANFI

Gene
secM
Protein
Secretion monitor
Organism
Yersinia pseudotuberculosis serotype O:1b (strain IP 31758)
Length
177 amino acids
Function
Regulates secA expression by translational coupling of the secM secA operon. Translational pausing at a specific Pro residue 5 residues before the end of the protein may allow disruption of a mRNA repressor helix that normally suppresses secA translation initiation.
Similarity
Belongs to the SecM family.
Mass
19.805 kDa
Sequence
MIGILNRWRQFGRRYFWPHLLLGMVAASLGVPSNLSGVPDHAALANTSSSQSRQNHGTTNFNSLALLHDIHRRPSFSVDYWQQHALRTVIRHLSFALAPQAAYARVQEVAETERVAPSKIQQLALLDTLNALLTHEFKPPAIIRYTEQVERPVLSPYKPGLWLAQVQGIRAGPANLS

Gene
secM
Protein
Secretion monitor
Organism
Yersinia pestis bv. Antiqua (strain Antiqua)
Length
177 amino acids
Function
Regulates secA expression by translational coupling of the secM secA operon. Translational pausing at a specific Pro residue 5 residues before the end of the protein may allow disruption of a mRNA repressor helix that normally suppresses secA translation initiation.
Similarity
Belongs to the SecM family.
Mass
19.847 kDa
Sequence
MIGILNRWRQFGRRYFWPHLLLGMVAASLGVPLNLSGVPDHAALANTSSSQSRQNHGTTNFNSLALLHDIHRRLSFSVDYWQQHALRTVIRHLSFALAPQAAYARVQEVAETERVAPSKIQQLALLDTLNALLTHEFKPPAIIRYTEQVERPVLSPYKPGLWLAQVQGIRAGPANLS

Gene
secM
Protein
Secretion monitor
Organism
Yersinia pestis
Length
177 amino acids
Function
Regulates secA expression by translational coupling of the secM secA operon. Translational pausing at a specific Pro residue 5 residues before the end of the protein may allow disruption of a mRNA repressor helix that normally suppresses secA translation initiation.
Similarity
Belongs to the SecM family.
Mass
19.847 kDa
Sequence
MIGILNRWRQFGRRYFWPHLLLGMVAASLGVPLNLSGVPDHAALANTSSSQSRQNHGTTNFNSLALLHDIHRRLSFSVDYWQQHALRTVIRHLSFALAPQAAYARVQEVAETERVAPSKIQQLALLDTLNALLTHEFKPPAIIRYTEQVERPVLSPYKPGLWLAQVQGIRAGPANLS

Gene
secM
Protein
Secretion monitor
Organism
Yersinia pestis bv. Antiqua (strain Angola)
Length
177 amino acids
Function
Regulates secA expression by translational coupling of the secM secA operon. Translational pausing at a specific Pro residue 5 residues before the end of the protein may allow disruption of a mRNA repressor helix that normally suppresses secA translation initiation.
Similarity
Belongs to the SecM family.
Mass
19.847 kDa
Sequence
MIGILNRWRQFGRRYFWPHLLLGMVAASLGVPLNLSGVPDHAALANTSSSQSRQNHGTTNFNSLALLHDIHRRLSFSVDYWQQHALRTVIRHLSFALAPQAAYARVQEVAETERVAPSKIQQLALLDTLNALLTHEFKPPAIIRYTEQVERPVLSPYKPGLWLAQVQGIRAGPANLS

Gene
secM
Protein
Secretion monitor
Organism
Yersinia pestis bv. Antiqua (strain Nepal516)
Length
177 amino acids
Function
Regulates secA expression by translational coupling of the secM secA operon. Translational pausing at a specific Pro residue 5 residues before the end of the protein may allow disruption of a mRNA repressor helix that normally suppresses secA translation initiation.
Similarity
Belongs to the SecM family.
Mass
19.847 kDa
Sequence
MIGILNRWRQFGRRYFWPHLLLGMVAASLGVPLNLSGVPDHAALANTSSSQSRQNHGTTNFNSLALLHDIHRRLSFSVDYWQQHALRTVIRHLSFALAPQAAYARVQEVAETERVAPSKIQQLALLDTLNALLTHEFKPPAIIRYTEQVERPVLSPYKPGLWLAQVQGIRAGPANLS

Gene
secM
Protein
Secretion monitor
Organism
Yersinia pestis (strain Pestoides F)
Length
177 amino acids
Function
Regulates secA expression by translational coupling of the secM secA operon. Translational pausing at a specific Pro residue 5 residues before the end of the protein may allow disruption of a mRNA repressor helix that normally suppresses secA translation initiation.
Similarity
Belongs to the SecM family.
Mass
19.847 kDa
Sequence
MIGILNRWRQFGRRYFWPHLLLGMVAASLGVPLNLSGVPDHAALANTSSSQSRQNHGTTNFNSLALLHDIHRRLSFSVDYWQQHALRTVIRHLSFALAPQAAYARVQEVAETERVAPSKIQQLALLDTLNALLTHEFKPPAIIRYTEQVERPVLSPYKPGLWLAQVQGIRAGPANLS

Gene
secM
Protein
Secretion monitor
Organism
Yersinia pseudotuberculosis serotype I (strain IP32953)
Length
177 amino acids
Function
Regulates secA expression by translational coupling of the secM secA operon. Translational pausing at a specific Pro residue 5 residues before the end of the protein may allow disruption of a mRNA repressor helix that normally suppresses secA translation initiation.
Similarity
Belongs to the SecM family.
Mass
19.805 kDa
Sequence
MIGILNRWRQFGRRYFWPHLLLGMVAASLGVPSNLSGVPDHAALANTSSSQSRQNHGTTNFNSLALLHDIHRRPSFSVDYWQQHALRTVIRHLSFALAPQAAYARVQEVAETERVAPSKIQQLALLDTLNALLTHEFKPPAIIRYTEQVERPVLSPYKPGLWLAQVQGIRAGPANLS

Gene
secM
Protein
Secretion monitor
Organism
Proteus mirabilis (strain HI4320)
Length
175 amino acids
Function
Regulates secA expression by translational coupling of the secM secA operon. Translational pausing at a specific Pro residue 5 residues before the end of the protein may allow disruption of a mRNA repressor helix that normally suppresses secA translation initiation.
Similarity
Belongs to the SecM family.
Mass
19.534 kDa
Sequence
MSIINFWRQFGRRYFWSHLLLGMVAAGIGMPSLVSAHAENPSQTDTPSSQNRQSQALIAFDNLFLRQSVQNPASSFTFNYWQQHAVKNVIKQLSFAFTIHSPELMVKAKDEPSPVANVAEVMLDTLYALLTQAPSSTLVNLPISRGVLTENRISYHTGLWLAQIRGIRAGPYLTA

Gene
secM
Protein
Secretion monitor
Organism
Photorhabdus luminescens subsp. laumondii (strain DSM 15139 / CIP 105565 / TT01)
Length
174 amino acids
Function
Regulates secA expression by translational coupling of the secM secA operon. Translational pausing at a specific Pro residue 5 residues before the end of the protein may allow disruption of a mRNA repressor helix that normally suppresses secA translation initiation.
Similarity
Belongs to the SecM family.
Mass
19.331 kDa
Sequence
MGILNLWRQFGRRYFWSHLLLGVVAASIGAPTILAGVTDNISQANTSPSQSWQNQALSAFDNLFSLQNVQHQPANGVNYWQQHAVRNVIRQLSFAFSISQPMSDETAKQSIRLSSSNIQQLVLETLNTLLIREPKPPEPVLDIPFLNVASQSSYILTLWIAKAQGIRAGPTAYL

Gene
secM
Protein
Secretion monitor
Organism
Pectobacterium atrosepticum (strain SCRI 1043 / ATCC BAA-672)
Length
171 amino acids
Function
Regulates secA expression by translational coupling of the secM secA operon. Translational pausing at a specific Pro residue 5 residues before the end of the protein may allow disruption of a mRNA repressor helix that normally suppresses secA translation initiation.
Similarity
Belongs to the SecM family.
Mass
19.241 kDa
Sequence
MIGILNRWRQFGRRYFWPHLLLGMVAASLGLPTSLNESQDIVSHPNSASSVSRQNSVSLSLTDLVALKEAHRRSSYSVDYWHQHAIRTVIRHLSFALTTPQTANAQQVDELQPHSLVLLDTLNALLTQDSQFPFVISPHAGRVTFYPQAHHQIGIWLAQIRGIRAGPYLLS

Gene
secM
Protein
Secretion monitor
Organism
Pectobacterium carotovorum subsp. carotovorum (strain PC1)
Length
171 amino acids
Function
Regulates secA expression by translational coupling of the secM secA operon. Translational pausing at a specific Pro residue 5 residues before the end of the protein may allow disruption of a mRNA repressor helix that normally suppresses secA translation initiation.
Similarity
Belongs to the SecM family.
Mass
19.16 kDa
Sequence
MIGILNRWRQFGRRYFWPHLLLGMVAASLGLPTSLNDSQDITSLPNSSSSVSRQNNVSLSLTDLVALKEAHRRSSYSVDYWHQHAIRTVIRHLSFALTTPQTVNAQQADELEPHSLVLLDTLNALLTQDSQYPLVISPRAGRVTFYPQAHHQVGIWLAQIRGIRAGPSLLS

Gene
secM
Protein
Secretion monitor
Organism
Escherichia coli (strain UTI89 / UPEC)
Length
170 amino acids
Function
Regulates secA expression by translational coupling of the secM secA operon. Translational pausing at a specific Pro residue 5 residues before the end of the protein may allow disruption of a mRNA repressor helix that normally suppresses secA translation initiation.
Similarity
Belongs to the SecM family.
Mass
18.866 kDa
Sequence
MSGILTRWRQFGKRYFWPHLLLGMVAASLGLPALSNAAEPNAPAKATTRNHEPSAKVNFGQLALLEANTRRPNSNYSVDYWHQHAIRTVIRHLSFAMAPQTLPVAEESLPLQAQHLALLDTLSALLTQEGTPSEKGYRIDYAHFTPQAKFSTPVWISQAQGIRAGPQRLS

Gene
secM
Protein
Secretion monitor
Organism
Shigella boydii serotype 4 (strain Sb227)
Length
170 amino acids
Function
Regulates secA expression by translational coupling of the secM secA operon. Translational pausing at a specific Pro residue 5 residues before the end of the protein may allow disruption of a mRNA repressor helix that normally suppresses secA translation initiation.
Similarity
Belongs to the SecM family.
Mass
18.934 kDa
Sequence
MSGILTRWRQFGKRYFWPHLLLGMVAASLGLPALSNAAEPNVPAKATTRNHEPSAKVNFGQLALLEANTRRPNSNYSVDYWHQYAIRTVIRHLSFAMAPQTLPVAEESLPLQAQHLALLDTLSALLTQEGTPSEKGYRIDYAHFTPQAKFSTPVWISQAQGIRAGPQRLT

Gene
secM
Protein
Secretion monitor
Organism
Shigella dysenteriae serotype 1 (strain Sd197)
Length
170 amino acids
Function
Regulates secA expression by translational coupling of the secM secA operon. Translational pausing at a specific Pro residue 5 residues before the end of the protein may allow disruption of a mRNA repressor helix that normally suppresses secA translation initiation.
Similarity
Belongs to the SecM family.
Mass
18.846 kDa
Sequence
MSGILTRWRQFGKRYFWPHLLLGMVAASLGLPALSNAAEPNAPAKATTRNHEPSAKVNFGQLALLEANTRHPNSNYSVDYWHQHAIRTVIRHLSFAMAPQTLPVAEESLPLQAQHLALLDTLSALLTQEGTPSEKGYRIDYAHFTPQAKFSTPVWISQAQGIRAGPQRLS

Gene
secM
Protein
Secretion monitor
Organism
Shigella flexneri serotype 5b (strain 8401)
Length
170 amino acids
Function
Regulates secA expression by translational coupling of the secM secA operon. Translational pausing at a specific Pro residue 5 residues before the end of the protein may allow disruption of a mRNA repressor helix that normally suppresses secA translation initiation.
Similarity
Belongs to the SecM family.
Mass
18.88 kDa
Sequence
MSGILTRWRQFGKRYFWPHLLLGMVAASLGLPALSNAAEPNAPAKATTRNHEPSAKVNFGQLALLEANTRRPNSNYSVDYWHQHAIRTVIRHLSFAMAPQTLPVAEESLPLQAQHLALLDTLSALLTQEGTPSEKGYRIDYAHFTPQAKFSTPVWISQAQGIRAGPQRLT

Gene
secM
Protein
Secretion monitor
Organism
Shigella flexneri
Length
170 amino acids
Function
Regulates secA expression by translational coupling of the secM secA operon. Translational pausing at a specific Pro residue 5 residues before the end of the protein may allow disruption of a mRNA repressor helix that normally suppresses secA translation initiation.
Similarity
Belongs to the SecM family.
Mass
18.88 kDa
Sequence
MSGILTRWRQFGKRYFWPHLLLGMVAASLGLPALSNAAEPNAPAKATTRNHEPSAKVNFGQLALLEANTRRPNSNYSVDYWHQHAIRTVIRHLSFAMAPQTLPVAEESLPLQAQHLALLDTLSALLTQEGTPSEKGYRIDYAHFTPQAKFSTPVWISQAQGIRAGPQRLT

Gene
secM
Protein
Secretion monitor
Organism
Shigella sonnei (strain Ss046)
Length
170 amino acids
Function
Regulates secA expression by translational coupling of the secM secA operon. Translational pausing at a specific Pro residue 5 residues before the end of the protein may allow disruption of a mRNA repressor helix that normally suppresses secA translation initiation.
Similarity
Belongs to the SecM family.
Mass
18.88 kDa
Sequence
MSGILTRWRQFGKRYFWPHLLLGMVAASLGLPALSNAAEPNAPAKATTRNHEPSAKVNFGQLALLEANTRRPNSNYSVDYWHQHAIRTVIRHLSFAMAPQTLPVAEESLPLQAQHLALLDTLSALLTQEGTPSEKGYRIDYAHFTPQAKFSTPVWISQAQGIRAGPQRLT

Gene
secM
Protein
Secretion monitor
Organism
Escherichia coli O127:H6 (strain E2348/69 / EPEC)
Length
170 amino acids
Function
Regulates secA expression by translational coupling of the secM secA operon. Translational pausing at a specific Pro residue 5 residues before the end of the protein may allow disruption of a mRNA repressor helix that normally suppresses secA translation initiation.
Similarity
Belongs to the SecM family.
Mass
18.875 kDa
Sequence
MSGILTRWRQFGKRYFWPHLLLGMVAASLGLPALSNAAEPNAPAKATTRNHEPSAKVNFGQLALLEANTRRPNSNYSVDYWHQHAIRTVIRHLSFAMAPQTLPVAEESLPLQAQHLALLDTLSALLTQEGTPSEKGYRIDYAHFTPQAKFSTPVWISHAQGIRAGPQRLS

Gene
secM
Protein
Secretion monitor
Organism
Escherichia coli O45:K1 (strain S88 / ExPEC)
Length
170 amino acids
Function
Regulates secA expression by translational coupling of the secM secA operon. Translational pausing at a specific Pro residue 5 residues before the end of the protein may allow disruption of a mRNA repressor helix that normally suppresses secA translation initiation.
Similarity
Belongs to the SecM family.
Mass
18.866 kDa
Sequence
MSGILTRWRQFGKRYFWPHLLLGMVAASLGLPALSNAAEPNAPAKATTRNHEPSAKVNFGQLALLEANTRRPNSNYSVDYWHQHAIRTVIRHLSFAMAPQTLPVAEESLPLQAQHLALLDTLSALLTQEGTPSEKGYRIDYAHFTPQAKFSTPVWISQAQGIRAGPQRLS

Gene
secM
Protein
Secretion monitor
Organism
Escherichia coli (strain 55989 / EAEC)
Length
170 amino acids
Function
Regulates secA expression by translational coupling of the secM secA operon. Translational pausing at a specific Pro residue 5 residues before the end of the protein may allow disruption of a mRNA repressor helix that normally suppresses secA translation initiation.
Similarity
Belongs to the SecM family.
Mass
18.88 kDa
Sequence
MSGILTRWRQFGKRYFWPHLLLGMVAASLGLPALSNAAEPNAPAKATTRNHEPSAKVNFGQLALLEANTRRPNSNYSVDYWHQHAIRTVIRHLSFAMAPQTLPVAEESLPLQAQHLALLDTLSALLTQEGTPSEKGYRIDYAHFTPQAKFSTPVWISQAQGIRAGPQRLT

Gene
secM
Protein
Secretion monitor
Organism
Escherichia coli O157:H7
Length
170 amino acids
Function
Regulates secA expression by translational coupling of the secM secA operon. Translational pausing at a specific Pro residue 5 residues before the end of the protein may allow disruption of a mRNA repressor helix that normally suppresses secA translation initiation.
Similarity
Belongs to the SecM family.
Mass
18.866 kDa
Sequence
MSGILTRWRQFGKRYFWPHLLLGMVAASLGLPALSNAAEPNAPAKATTRNHEPSAKVNFGQLALLEANTRRPNSNYSVDYWHQHAIRTVIRHLSFAMAPQTLPVAEESLPLQAQHLALLDTLSALLTQEGTPSEKGYRIDYAHFTPQAKFSTPVWISQAQGIRAGPQRLS

Gene
secM
Protein
Secretion monitor
Organism
Escherichia coli O7:K1 (strain IAI39 / ExPEC)
Length
170 amino acids
Function
Regulates secA expression by translational coupling of the secM secA operon. Translational pausing at a specific Pro residue 5 residues before the end of the protein may allow disruption of a mRNA repressor helix that normally suppresses secA translation initiation.
Similarity
Belongs to the SecM family.
Mass
18.846 kDa
Sequence
MSGILTRWRQFGKRYFWPHLLLGMVAASLGLPALSNAAEPNAPAKATTRNHEPSAKVNFGQLALLEANTRRPNSNYSVDYWHQHAIRTVIRHLSFAMAPQTLPVAEESLPLQAQHLALLDTLSALLTQEGTPSEKGYHIDYAHFTPQAKFSTPVWISQAQGIRAGPQRLS

Gene
secM
Protein
Secretion monitor
Organism
Escherichia coli O81 (strain ED1a)
Length
170 amino acids
Function
Regulates secA expression by translational coupling of the secM secA operon. Translational pausing at a specific Pro residue 5 residues before the end of the protein may allow disruption of a mRNA repressor helix that normally suppresses secA translation initiation.
Similarity
Belongs to the SecM family.
Mass
18.866 kDa
Sequence
MSGILTRWRQFGKRYFWPHLLLGMVAASLGLPALSNAAEPNAPAKATTRNHEPSAKVNFGQLALLEANTRRPNSNYSVDYWHQHAIRTVIRHLSFAMAPQTLPVAEESLPLQAQHLALLDTLSALLTQEGTPSEKGYRIDYAHFTPQAKFSTPVWISQAQGIRAGPQRLS

Gene
secM
Protein
Secretion monitor
Organism
Escherichia coli O8 (strain IAI1)
Length
170 amino acids
Function
Regulates secA expression by translational coupling of the secM secA operon. Translational pausing at a specific Pro residue 5 residues before the end of the protein may allow disruption of a mRNA repressor helix that normally suppresses secA translation initiation.
Similarity
Belongs to the SecM family.
Mass
18.88 kDa
Sequence
MSGILTRWRQFGKRYFWPHLLLGMVAASLGLPALSNAAEPNAPAKATTRNHEPSAKVNFGQLALLEANTRRPNSNYSVDYWHQHAIRTVIRHLSFAMAPQTLPVAEESLPLQAQHLALLDTLSALLTQEGTPSEKGYRIDYAHFTPQAKFSTPVWISQAQGIRAGPQRLT

Gene
secM
Protein
Secretion monitor
Organism
Escherichia coli (strain K12 / MC4100 / BW2952)
Length
170 amino acids
Function
Regulates secA expression by translational coupling of the secM secA operon. Translational pausing at a specific Pro residue 5 residues before the end of the protein may allow disruption of a mRNA repressor helix that normally suppresses secA translation initiation.
Similarity
Belongs to the SecM family.
Mass
18.88 kDa
Sequence
MSGILTRWRQFGKRYFWPHLLLGMVAASLGLPALSNAAEPNAPAKATTRNHEPSAKVNFGQLALLEANTRRPNSNYSVDYWHQHAIRTVIRHLSFAMAPQTLPVAEESLPLQAQHLALLDTLSALLTQEGTPSEKGYRIDYAHFTPQAKFSTPVWISQAQGIRAGPQRLT

Gene
secM
Protein
Secretion monitor
Organism
Escherichia coli (strain K12 / DH10B)
Length
170 amino acids
Function
Regulates secA expression by translational coupling of the secM secA operon. Translational pausing at a specific Pro residue 5 residues before the end of the protein may allow disruption of a mRNA repressor helix that normally suppresses secA translation initiation.
Similarity
Belongs to the SecM family.
Mass
18.88 kDa
Sequence
MSGILTRWRQFGKRYFWPHLLLGMVAASLGLPALSNAAEPNAPAKATTRNHEPSAKVNFGQLALLEANTRRPNSNYSVDYWHQHAIRTVIRHLSFAMAPQTLPVAEESLPLQAQHLALLDTLSALLTQEGTPSEKGYRIDYAHFTPQAKFSTPVWISQAQGIRAGPQRLT

Gene
secM
Protein
Secretion monitor
Organism
Escherichia coli O1:K1 / APEC
Length
170 amino acids
Function
Regulates secA expression by translational coupling of the secM secA operon. Translational pausing at a specific Pro residue 5 residues before the end of the protein may allow disruption of a mRNA repressor helix that normally suppresses secA translation initiation.
Similarity
Belongs to the SecM family.
Mass
18.866 kDa
Sequence
MSGILTRWRQFGKRYFWPHLLLGMVAASLGLPALSNAAEPNAPAKATTRNHEPSAKVNFGQLALLEANTRRPNSNYSVDYWHQHAIRTVIRHLSFAMAPQTLPVAEESLPLQAQHLALLDTLSALLTQEGTPSEKGYRIDYAHFTPQAKFSTPVWISQAQGIRAGPQRLS

Gene
secM
Protein
Secretion monitor
Organism
Escherichia coli O6:K15:H31 (strain 536 / UPEC)
Length
170 amino acids
Function
Regulates secA expression by translational coupling of the secM secA operon. Translational pausing at a specific Pro residue 5 residues before the end of the protein may allow disruption of a mRNA repressor helix that normally suppresses secA translation initiation.
Similarity
Belongs to the SecM family.
Mass
18.866 kDa
Sequence
MSGILTRWRQFGKRYFWPHLLLGMVAASLGLPALSNAAEPNAPAKATTRNHEPSAKVNFGQLALLEANTRRPNSNYSVDYWHQHAIRTVIRHLSFAMAPQTLPVAEESLPLQAQHLALLDTLSALLTQEGTPSEKGYRIDYAHFTPQAKFSTPVWISQAQGIRAGPQRLS

Gene
secM
Protein
Secretion monitor
Organism
Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)
Length
170 amino acids
Function
Regulates secA expression by translational coupling of the secM secA operon. Translational pausing at a specific Pro residue 5 residues before the end of the protein may allow disruption of a mRNA repressor helix that normally suppresses secA translation initiation.
Similarity
Belongs to the SecM family.
Mass
18.866 kDa
Sequence
MSGILTRWRQFGKRYFWPHLLLGMVAASLGLPALSNAAEPNAPAKATTRNHEPSAKVNFGQLALLEANTRRPNSNYSVDYWHQHAIRTVIRHLSFAMAPQTLPVAEESLPLQAQHLALLDTLSALLTQEGTPSEKGYRIDYAHFTPQAKFSTPVWISQAQGIRAGPQRLS

Gene
secM
Protein
Secretion monitor
Organism
Escherichia coli (strain ATCC 8739 / DSM 1576 / Crooks)
Length
170 amino acids
Function
Regulates secA expression by translational coupling of the secM secA operon. Translational pausing at a specific Pro residue 5 residues before the end of the protein may allow disruption of a mRNA repressor helix that normally suppresses secA translation initiation.
Similarity
Belongs to the SecM family.
Mass
18.88 kDa
Sequence
MSGILTRWRQFGKRYFWPHLLLGMVAASLGLPALSNAAEPNAPAKATTRNHEPSAKVNFGQLALLEANTRRPNSNYSVDYWHQHAIRTVIRHLSFAMAPQTLPVAEESLPLQAQHLALLDTLSALLTQEGTPSEKGYRIDYAHFTPQAKFSTPVWISQAQGIRAGPQRLT

Gene
secM
Protein
Secretion monitor
Organism
Escherichia coli (strain K12)
Length
170 amino acids
Function
Regulates secA expression by translational coupling of the secM secA operon. Ribosomes translating the C-terminal region of secM can disrupt an RNA repressor helix that normally blocks secA translation initiation, derepressing the expression of secA. Translational pausing of secM at Pro-166 under secretion-limiting conditions increases the duration of the disruption and thus increases secA expression. This is controlled by interaction of the secM signal peptide with secA and the translocon, possibly by secA pulling the paused secM out of the ribosome. The arrest sequence (150-FXXXXWIXXXXGIRAGP-166) is sufficient to cause arrest of unrelated proteins. Elongation arrest can be alleviated by mutations in the 23S rRNA or in ribosomal protein L22.
Similarity
Belongs to the SecM family.
Mass
18.88 kDa
Sequence
MSGILTRWRQFGKRYFWPHLLLGMVAASLGLPALSNAAEPNAPAKATTRNHEPSAKVNFGQLALLEANTRRPNSNYSVDYWHQHAIRTVIRHLSFAMAPQTLPVAEESLPLQAQHLALLDTLSALLTQEGTPSEKGYRIDYAHFTPQAKFSTPVWISQAQGIRAGPQRLT

Gene
secM
Protein
Secretion monitor
Organism
Escherichia coli O17:K52:H18 (strain UMN026 / ExPEC)
Length
170 amino acids
Function
Regulates secA expression by translational coupling of the secM secA operon. Translational pausing at a specific Pro residue 5 residues before the end of the protein may allow disruption of a mRNA repressor helix that normally suppresses secA translation initiation.
Similarity
Belongs to the SecM family.
Mass
18.866 kDa
Sequence
MSGILTRWRQFGKRYFWPHLLLGMVAASLGLPALSNAAEPNAPAKATTRNHEPSAKVNFGQLALLEANTRRPNSNYSVDYWHQHAIRTVIRHLSFAMAPQTLPVAEESLPLQAQHLALLDTLSALLTQEGTPSEKGYRIDYAHFTPQAKFSTPVWISQAQGIRAGPQRLS

Gene
secM
Protein
Secretion monitor
Organism
Citrobacter koseri (strain ATCC BAA-895 / CDC 4225-83 / SGSC4696)
Length
168 amino acids
Function
Regulates secA expression by translational coupling of the secM secA operon. Translational pausing at a specific Pro residue 5 residues before the end of the protein may allow disruption of a mRNA repressor helix that normally suppresses secA translation initiation.
Similarity
Belongs to the SecM family.
Mass
18.576 kDa
Sequence
MSGILTRWRQLGRRYFWPHLLLGMVAASFGLPALSNAAEPNTPAKATASNHDQSVKVNFSQLALLEASNRRPNFTVDYWHQHAIRTVIRHLSFAMAPQTLPVVEESSPLQAHHIALLNTLSAMLTQEGTPPTIVRRVARAHFTPQASFSVPAWISQAQGIRAGPQRLS

Gene
secM
Protein
Secretion monitor
Organism
Erwinia tasmaniensis (strain DSM 17950 / CIP 109463 / Et1/99)
Length
167 amino acids
Function
Regulates secA expression by translational coupling of the secM secA operon. Translational pausing at a specific Pro residue 5 residues before the end of the protein may allow disruption of a mRNA repressor helix that normally suppresses secA translation initiation.
Similarity
Belongs to the SecM family.
Mass
18.483 kDa
Sequence
MIGILNRWRQFGRRYFWPHLLLGMVAASFGLPQASAHDGTTLAETSARSLNIGSATRIDRLVMLQESARRSSFSVDYWHQHAIRTVIRHLSFSLTPSVSTVAATVPLEAHKLALLDTLNALLTHEARPPVIIRHTTQRQVSSSPRHHIGLWLAQVCGIRAGPPSALS

Gene
secM
Protein
Secretion monitor
Organism
Sodalis glossinidius (strain morsitans)
Length
167 amino acids
Function
Regulates secA expression by translational coupling of the secM secA operon. Translational pausing at a specific Pro residue 5 residues before the end of the protein may allow disruption of a mRNA repressor helix that normally suppresses secA translation initiation (By similarity).
Similarity
Belongs to the SecM family.
Mass
18.62 kDa
Sequence
MGILNRWRQIGRRYFWPHLLLGIVAAGFGVPLLPGGGQEMLYQADNCPSLSRQSAFQAGFSQLARLKDVPCRTTYAVDYWHQHAIRTVIRHLSIAWAPAPLPEAVAPLRVQHQVLLTTLGLLLNREARPPVLVRRLRSTGHVAFIDNRSGIRLTQQQGIRAGPHAAV

Gene
secM
Protein
Secretion monitor
Organism
Cronobacter sakazakii (strain ATCC BAA-894)
Length
167 amino acids
Function
Regulates secA expression by translational coupling of the secM secA operon. Translational pausing at a specific Pro residue 5 residues before the end of the protein may allow disruption of a mRNA repressor helix that normally suppresses secA translation initiation.
Similarity
Belongs to the SecM family.
Mass
18.306 kDa
Sequence
MPGIFTRWRQFGRRYFWPHLLLGMVAASLGLPALNNNAEPAAPAEASTSHTGTLRSFDSLALISETSRRSASFGVDYWQQHAIRTVIRHLSFAMAPQALPMAMEESLPLNAQHLALLDTLSAMLTQDLQPAAAQVQPAPRLLPPLSFTVSAWIRQVQGIRAGPRLLA

Gene
secM
Protein
Secretion monitor
Organism
Klebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578)
Length
165 amino acids
Function
Regulates secA expression by translational coupling of the secM secA operon. Translational pausing at a specific Pro residue 5 residues before the end of the protein may allow disruption of a mRNA repressor helix that normally suppresses secA translation initiation.
Similarity
Belongs to the SecM family.
Mass
18.121 kDa
Sequence
MSGLLTRWRQFGRRYFWPHLLLGMVAASLGLPALSNGHETAAPAKATASNHNPSKVNFSQLALLETNRRPSFTVDYWHQHAIRTVIRHLSFAMAPQALPVAEETSPLQAQHLALLDTLSALLTQDSTPPVVIRQAGYIPSSYSAFRVSAWISQVAGIRAGPQRLS

Gene
secM
Protein
Secretion monitor
Organism
Salmonella choleraesuis (strain SC-B67)
Length
165 amino acids
Function
Regulates secA expression by translational coupling of the secM secA operon. Translational pausing at a specific Pro residue 5 residues before the end of the protein may allow disruption of a mRNA repressor helix that normally suppresses secA translation initiation.
Similarity
Belongs to the SecM family.
Mass
18.117 kDa
Sequence
MSGILTRWRQLGRRYFWPHLLLGMVAASFGLPALSNAAETNTPARTTASTASKVNFSHLALLEASNRRPNFTVDYWHQHAIRTVIRHLSFAMAPQTLPVADAPSPLQAHHIALLNTLSAMLTQEGTPPAIVRRLSLAYFAPQTAFSIPAWISQAQGIRAGPQRLS

Gene
secM
Protein
Secretion monitor
Organism
Salmonella paratyphi A (strain ATCC 9150 / SARB42)
Length
165 amino acids
Function
Regulates secA expression by translational coupling of the secM secA operon. Translational pausing at a specific Pro residue 5 residues before the end of the protein may allow disruption of a mRNA repressor helix that normally suppresses secA translation initiation.
Similarity
Belongs to the SecM family.
Mass
18.117 kDa
Sequence
MSGILTRWRQLGRRYFWPHLLLGMVAASFGLPALSNAAETNTPARTTASTASKVNFSHLALLEASNRRPNFTVDYWHQHAIRTVIRHLSFAMAPQTLPVADAPSPLQAHHIALLNTLSAMLTQEGTPPAIVRRLSLAYFAPQTAFSIPAWISQAQGIRAGPQRLS

Gene
secM
Protein
Secretion monitor
Organism
Salmonella paratyphi B (strain ATCC BAA-1250 / SPB7)
Length
165 amino acids
Function
Regulates secA expression by translational coupling of the secM secA operon. Translational pausing at a specific Pro residue 5 residues before the end of the protein may allow disruption of a mRNA repressor helix that normally suppresses secA translation initiation.
Similarity
Belongs to the SecM family.
Mass
18.117 kDa
Sequence
MSGILTRWRQLGRRYFWPHLLLGMVAASFGLPALSNAAETNTPARTTASTASKVNFSHLALLEASNRRPNFTVDYWHQHAIRTVIRHLSFAMAPQTLPVADAPSPLQAHHIALLNTLSAMLTQEGTPPAIVRRLSLAYFAPQTAFSIPAWISQAQGIRAGPQRLS

Gene
secM
Protein
Secretion monitor
Organism
Salmonella typhi
Length
165 amino acids
Function
Regulates secA expression by translational coupling of the secM secA operon. Translational pausing at a specific Pro residue 5 residues before the end of the protein may allow disruption of a mRNA repressor helix that normally suppresses secA translation initiation.
Similarity
Belongs to the SecM family.
Mass
18.117 kDa
Sequence
MSGILTRWRQLGRRYFWPHLLLGMVAASFGLPALSNAAETNTPARTTASTASKVNFSHLALLEASNRRPNFTVDYWHQHAIRTVIRHLSFAMAPQTLPVADAPSPLQAHHIALLNTLSAMLTQEGTPPAIVRRLSLAYFAPQTAFSIPAWISQAQGIRAGPQRLS

Gene
secM
Protein
Secretion monitor
Organism
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Length
165 amino acids
Function
Regulates secA expression by translational coupling of the secM secA operon. Translational pausing at a specific Pro residue 5 residues before the end of the protein may allow disruption of a mRNA repressor helix that normally suppresses secA translation initiation.
Similarity
Belongs to the SecM family.
Mass
18.151 kDa
Sequence
MSGILTRWRQLGRRYFWPHLLLGMVAASFGLPALSNAAETNTPARTTASTASKVNFSHFALLEASNRRPNFTVDYWHQHAIRTVIRHLSFAMAPQTLPVADAPSPLQAHHIALLNTLSAMLTQEGTPPAIVRRLSLAYFAPQTAFSIPAWISQAQGIRAGPQRLS