Function
Component of the SDC complex that functions in sex determination and in X chromosome dosage compensation specifically in hermaphrodite (XX) animals (PubMed:8431944, PubMed:11937488). Plays a central role in the recruitment of the condensin I-like dosage compensation complex to the male sex-determining autosomal gene her-1, thereby contributing to its repression and initiating hermaphrodite sexual development (PubMed:11937488, PubMed:14660541). Involved in the recruitment and assembly of the dosage compensation complex and the dosage compensation protein dpy-21 onto the X chromosomes in hermaphrodites, which leads to a reduction of X-linked gene transcription and an equalization of X-linked gene expression between the sexes (PubMed:14660541, PubMed:9458050, PubMed:8939870, PubMed:9056777, PubMed:8939869).
Sequence
MSDEPPIVLPTEEDGPFSNCVSIAFVNDKSIPVELRIRKAIRGKVTFTQELVVAARRLYLDGELERPDLNYHVAADFYDPFMIPVPDHRNWEYNPLYPREWPRLIDRDLVQKIKMSNTYKKNQARRKRRRLLRIFHRKRGGEFLNYLWHSKENDVHYKRYMAAYQFPLPFEKCIRDVVREELKDPETSFSKPPSVVHHSKIRPATPDLLKLAKYLGKDRFCFIVTPFKFRSQFRLRYYKKSPFKRSNILEKWLKFKKVRDQGVFNIRDAAREVKKLLQRKNVYHMTDPQCEQEFWDVYRLQMQWLEEDNIEENITMLRENLSKVTDEEFNRSVYIMRPENRASIHDDVTFTTDAEINLKPIVLELFRNNMPLEDIRQVKECIDDMINLTVCQELIPQVATIETVRDYSGVEQHRLKYIRPENELEIMFQLATVLVKNENTHDQEITSPMFALLRTEQYLWSIPLRPFLRMYTDWRKTKLNFKKFRKFSPELVSKAPIDLFKVFLTTNMDKKGVATKDTDCFDYRTASEIKKLYHEEFIRVRPIIEHQRFHRCYTSVITEEPLPNPFYWVHRGQWEKVYECNWKQRVKPLAGRFSWKTKHPNICDLPRLEKDDKQEMEMLAKMREKIREYNKEKEKHPFYVSSSLPEFASTSDFVKFPISNTGIKYTAPRRNQPKVQRSLVTYTRFRLAELEDKDFSFPEEKMLEKNRLLEKLNFEERLQLDALMSKDVKYKPRMIPEKGFLQLQDEKLILKRLCEKEDEWSGKQKRRFPDLYEQATQEAERLGDPDASTSGTSNKELGLLPVWKHDDFRDLKKINVLGSKEYPISSPYLIKRLHYDIHLEIVRDKLKSWIYRTELWEKMKPVYERLKRDKEKREKEWHEMRAAQRAQKEKEEEDQRRMDMGIEHGQESLLKSITPEVEQQILLPISRENSFEEMLPAPQEAYDEDLDQDIDIHFDGAESVCTGIRLDSEDRELVDSPDQVENEEPERVEAVTENIRQEMSDAEMRDLMRKKREQYSMLFPNVPQPFQPLNRFDVTAPGAGIVPPYDEAPDFDLSAYLEEDHVRIPTLSTVEINSLLKDQDLVEEQEIVEEEETPLVVEEPDIPAAPVLSAEEKASRISREMSALRKLPDAAFNYASDRDGVVVEEVETIEEIQEIYNDKLEKMIAARLGSIAQGANIERLSEDQLLGDQGSEDISFEEIQVDLLLESGVEVQVNQSVTISRSSTSFESLLVEDPEEHPEQLPVSASEKANNQIVPEVEVEGSVVPVTNQQEENVTSEGPTLQEGSSIPSSSHIYTVDELLGTESPGPEATETPVAEESPKKKSGKTTRGRPKKVKENLKKRIQPRRGQKEEAAHEPEVVEEQEQVEPEVGPEVVHEPVPAPAAQLETEPIEQQIEEPDKVFEPIIEALPLFETSPVPAPEGNIPSRAHSSDDDVQVISSETDPNGPINLVEQVQNDKLTAYQYSTEELLGEYGELDEAGAPSPSEIVVHDEVLQDEVLQPNPKSSKKRGRRRKKTPPHIAKARKVFTSISKTEEIELAPTPTQQSRKRMANVSSEEATATRRQKRAKVEEPNDSDVSRVLTPEPEDLHETERPGHVGEEGFETPSLRTGRESTASSVKTSRSKRLFLSKNNPVPRMRIQSQAGTNASPTPARRTGVARDSVSPDGASEKLKQLPKSVQDIFEVFDVERSAERGESATVTNLEGPVKIEIEDENWMAPPAITETSRKSKKRLRAEKQQQILDDIKLELNGEPPQKRECEILMERVQVKIEEGVENADCRIVQANFNCKSVEEHETLPLKIIRVFEENEKPVHKFFMTQIIWKEINEAFMTDPEKFMLLVRILFSDRNISGQIYKISMTVTDRIKGFDDDFIKLLTQFPKKLSQEHKPLVDYNKLAHALREKASLHLNNHKITPFTFHGVISNITEMKEKIIGRCEIGMLTDGDRDVLNSTENMLLGAYMKSVLRMTAQSQVSWAHPEYIKRRLEMIYYGWRMFLGSGGFFRVALAINRKDVKPMSQQFRDFFIEYLKDVNENYAKAVELVQMDEDKLMEAMIEKAGLSSIDLLALDEDVQGQVSESHKHKCVQCSIRNQSVYFSSYSLLELHGKLHQNLHELAPEDADDCQDCYETLTSSFEVIVHRINHHHSRRCFFADD