Protein
Amiloride-sensitive sodium channel subunit beta-2
Function
Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Plays an essential role in electrolyte and blood pressure homeostasis, but also in airway surface liquid homeostasis, which is important for proper clearance of mucus.
Similarity
Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. SCNN1B subfamily.
Sequence
MIQGKLKRLKRYFTRALHRIQKGPGYTYKELLVWFCDNTNTHGPKRIIKEGPKKRVMWFILTLVFAGLVFWQWGLLILTYLSYGVSVSLSIGFKTMEFPAVTVCNTNPYKYSRVKPLLKDLDELVATALDRIQYSSQTQANTFTYNNTRQNVTLDPALWNHIPLVVIDENDPSNPVIHNIFDNSVFYSKNNLLRNSSEDQTSYAQRYKVAMKLCTNNNTQCVYRNFTSGVQALREWYLLQLSIIFSNVPLSDRVDMGFKAEDLILTCLFGGQPCSYRNFTHIYDADYGNCYIFNWGQEGDDTMSSANPGADFGLKLVLDIEQDEYLPFLQTTAAARLILHQQRSFPFVKDLGIYAKPGTETSIAVLVDQLQQMEAPYSSCTVNGSDIPVQNLYEEFNSSYSIQSCLRSCYQEEMVKTCKCAHYQYPLPNGSEYCTNNKHPDWVPCYYGLRDSVAIRENCISLCQQPCNDTHYKMVISMADWPSAGAEDWIFHVLSYEKDSSYDITVNRNGIIRLNIYFQEFNYRSISESEATNVVWLLSNLGGQFGFWMGGSVLCIIEFGEIIIDCMWITILKLLAWIRNRRQRRQRPQYADPPPTVSELVEAHTNPGFQHDDGNHVTEDIPGTPPPNYDSLRVNTIEPVSSDEEN