Protein
ALK tyrosine kinase receptor homolog scd-2
Organism
Caenorhabditis elegans
Function
Probable tyrosine-protein kinase receptor which regulates the dauer/non-dauer developmental decision probably by controlling daf-3 transcriptional activity in parallel or together with the TGF-beta pathway (PubMed:11063683, PubMed:18674914). Regulates integration of conflicting sensory cues in AIA interneurons (PubMed:21414922). May act as a receptor for hen-1 (PubMed:18674914, PubMed:21414922).
Similarity
Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.
Sequence
MRKRRLWWFVVLFRVTLVGAILPNETFDVRRYYADRFLIEDEENGSSRSYYISAESKAKAAEQFALLAPNCSLTSDIQENTCNETSSFCDHRVDSTYKTYHYEQEKCNCFIETCDEETNSTELMVLYPDCYCGKREKHCDLSKEKCHWTPDSDHDDLKFEVFESSNKVLFDYMLQAGSEKANLKMNKVSMVSKFFRQSGFNCSLRFMHHFTHQSSTSRLVVRSILQSGEKKNLYEHWLKPASVFWVPVQVAIGSYAEPFKISIDCETGFPPKKKKNKPFTCSIADIYFENCGEIRDPIEQCSRGDQFLCSISANTRCLQNAQCDSRIDCDDESDEMDCGNINGTMCDFNGQDYCNSWYQVTNVTDYHERLSEPTTVAPLNKLNEVPLHLFRLQSPSAKIKEAMRGSGNMLVFDHKPNPLTRRTSALVSPELPRTNPEAYDEKSPLFKSCKLRFYLCSRTYSKVWQISVISKGINPMESGRTIIYEAGYTLIPKENCTWERVFVNIPRQNAGFRIGIFVTNYFPGSEEYVAIDNLSFSPTCFERDINQSTWDIPDLFINTCGASGFEQPQNCDHNRELDGQTGHFLKEDGTQQWTVPVTGFYRMEICGAGGGSNSKASGDTGDCVTLQVHLIENLSLRMLIGQMGESPCFTEHDDELRPSSCSKISHNYVYDGKRGAAGGGATLLTVEKDLWNVVAGGGAGASWDGFDMEVGYGASAIHVKPDQRCNETCKAVSHTDFIVERRDNRCPGEKGESTVFGGFGGGGNSCGMLGGSGAGYQAGNPFGKSRARSGSSNVSIDFSKSPIYYQSERLDEGYIKIAFCRKRCEPPTVCRFRKDYFEEEYCGCPDGSNVTDTEEACAFPLVCPSSSTNQYRNFTYEPFCLCNNGKEIYDVYNDTCEEIQIWTLYNITFLIFAALTIIGALFVVYHYRNREKQMKQEILDLTQMKSPDYLYDDIYFGRTTRKAALDSLPSISRDSIERGRVLGRGNFGEVYYGEYSGVKLAVKMISRTFSASQASQSDFCNEALCMGTFVDENVVRLIGIDFEKVPYMIALEYMEGGDLLSFVKECRPNQVSLNPFQLAMSDLIKICCDVAAGCKCLETFGYVHRDIAARNILLTTRGPQRVAKIADFGMAKEITYGTEYYRINGRTMMPIKWTPPEAFIDGVFTTKSDIWSFGVLCWEVFSLGVVPYPNRRNEEVMLMLTEGARLEYPYGIPTRVYQLMRDCWKTAAADRPKFVDVVEIFQDIQDDPASVGMPFPIHPAVRATFAHSQSTPVSVETPMTAMTEISLNSTFTDASTVKVSAQQDMQDRIQLHELMLTREHPYTSELTSYVVNSIRKDLARVQYENGLTSVPQPEYLSPENNDESVQLIPQSNTVTDQTPPTSLIDLNRLGVQNTGPTLHRPDSLNFNDPYSSVPLLECQTR