Protein
Ribosome maturation protein SBDS
Organism
Caenorhabditis elegans
Function
Required for the assembly of mature ribosomes and ribosome biogenesis. Together with K10C3.5b/EFL1, triggers the GTP-dependent release of ribosome maturation factors from 60S pre-ribosomes in the cytoplasm, thereby activating ribosomes for translation competence by allowing 80S ribosome assembly. Required for normal levels of protein synthesis. May play a role in cellular stress resistance. May play a role in cellular response to DNA damage. May play a role in cell proliferation (By similarity).
Similarity
Belongs to the SDO1/SBDS family.
Sequence
MSKNIKTPTNQKVLTNVAVVRMKKTGKRFEIACYKNKVVNWRNKSEKDIDEVLQTHTVFSNVSKGQLSKKEELIAAFGIEDQLEICKIILDKGDLQVSEKERQAASDQSLKEVSQLIASMVVNPETKRPVPPSVIDKALQEMHFSLKPNRSSKQQALDAIPKLRETLKIERAKMKIRVAIPTKEAKSVHTKLKTLFSDVEVDDWQDGSLEMVGLIEPGSFRALDDLVRNETKGHGRLEILSLKDVVEGELQIS