Protein
Modification methylase Sau96I
Organism
Staphylococcus aureus
Function
This methylase recognizes the double-stranded sequence GGNCC, causes specific methylation on C-4 on both strands, and protects the DNA from cleavage by the Sau96I endonuclease.
Similarity
Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.
Sequence
MRLNKGSIIEKMKNQNIKTQTELAEKIDISKSQLSFMFSDEYEPLKKNVIKLADVLKVSPNDIILDEEDQMPINSDFNRYDYKLDEFIDVSNVRKNKDYNVFETFAGAGGLALGLESAGLSTYGAVEIDKNAAETLRINRPKWKVIENDIEFIADNLDEFIDEEIDILSGGYPCQTFSYAGKRNGFADTRGTLFYPYSKILSKLKPKAFIAENVRGLVNHDDGKTLEVMLKVFIKEGYEVYWNILNSWNYDVAQKRERIVIIGIREDLVKEQKYPFRFPLAQVYKPVLKDVLKDVPKSKVTAYSDKKREVMKLVPPGGCWVDLPEQIAKDYMGKSWYSGGGKRGMARRISWDEPCLTLTTSPSQKQTERCHPDETRPFSIREYARIQSFPDEWEFSGGVGAQYRQIGNAVPVNLAKYIGKSLVHYLNQFN