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sarA

Gene
sarA
Protein
Oligopeptide-binding protein SarA
Organism
Streptococcus gordonii (strain Challis / ATCC 35105 / BCRC 15272 / CH1 / DL1 / V288)
Length
663 amino acids
Function
May be involved in the expression of cell surface properties important for colonization of the human oral cavity. It may also be involved in uptake processes.
Similarity
Belongs to the bacterial solute-binding protein 5 family.
Mass
73.371 kDa
Sequence
MKKGKILALAGVALLATGVLAACSNSTSNSSNSSSSGADQVFNYIYEVDPENLNYLISSKAATTDLTANLIDGLLENDNYGNLVPSMAEDWTVSKDGLTYTYTLRKDAKWYTSDGEEYADVKAQDFVAGLKYAADNKSETLYLVQSSIKGLDDYVNGKTKDFSSVGVKAVDDHTVQYTLNEPESFWNSKTTMGILYPVNEEFLKSKGDKFAQSADPTSLLYNGPFLLKSITSKSSIEFAKNPNYWDKDNVHVSDVKLTYFDGQDQGKPAEQFAKGALSAARLAPTSATFSKVEKEFKDNIVYTPQDSTSYLVGVNIDRQAYNHTAKSSDAQKSSTKKALMNKDFRQALSFAFDRTAYASQVNGKEGATKMLRNLYIPPTFVQADGKSFGELVKEKVASYGDEWKDVNFDDAQDGLYNKEKAKAEFAKAKKALQEEGVEFPIHLDMPVDQTATAKVQRVQSLKQSIESSLGTDNVVVDIHQMKTDDVLNITYYAASAAEEDWDISDNVGWSPDYQDPSTYLEIIKPGGENTKTFLGFDGKENAAAEQVGLKEYAKLVDEAAAEKTDVNKRYEKYATAQAWLTDSALLIPTTSRTGRPVLTKIVPFTAPFAWSGAKGRDMASYKYLKLQDKAVTAKEYQKAQEKWNKERAESNKKAQEELEKHVK

Gene
sarA
Protein
GTP-binding protein Sar1A
Organism
Dictyostelium discoideum
Length
188 amino acids
Function
Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules (By similarity).
Similarity
Belongs to the small GTPase superfamily. SAR1 family.
Mass
21.214 kDa
Sequence
MFLFDWFWNVLSFLGLYNKNAKILFLGLDNAGKTTLLGVLKDGRLSSYLPTFHPTSEELAMGNIRFKAFDLGGHESARRLWKDYYPSVDAIVYLIDSSAQDRFVESKKELDSLLSSDELANVPFLILGNKVDIGNTSEEKFRASLGLTQTTGKGKTTLNGVRPIEVFMCSVVKRYGYAEGFRWLANYL

Gene
sarA
Protein
Transcriptional regulator SarA
Organism
Staphylococcus aureus (strain MSSA476)
Length
124 amino acids
Function
Global regulator with both positive and negative effects that controls the expression of several virulence factors and the biofilm formation process in a cell density-dependent manner.
Similarity
Belongs to the SarA family.
Mass
14.718 kDa
Sequence
MAITKINDCFELLSMVTYADKLKSLIKKEFSISFEEFAVLTYISENKEKEYYLKDIINHLNYKQPQVVKAVKILSQEDYFDKKRNEHDERTVLILVNAQQRKKIESLLSRVNKRITEANNEIEL

Gene
sarA
Protein
Transcriptional regulator SarA
Organism
Staphylococcus aureus
Length
124 amino acids
Function
Global regulator with both positive and negative effects that controls expression of several virulence factors and biofilm formation process in a cell density-dependent manner. In a strain-dependent manner plays a role in multidrug resistance mechanism. Is required for transcription of primary transcripts RNAII and RNAIII generated by agr (virulence accessory gene regulator) locus. Acts as a transcriptional activator of the genes encoding, among others, for fibronectin binding proteins (fnbA and fnbB), hemolysins (hla, hld, hlgB and hlgC), serine proteases (splA, splB, splD and splF) and of the bap gene, which is essential for biofilm development in some strains. Negatively regulates the expression of the genes for protein A (spa), lipase (lip), thermonuclease (nuc), immunodominant staphylococcal antigen B (isaB), staphylococcal serine and cysteine proteases (sspA and sspB), staphostatin B (sspC), metalloprotease aureolysin (aur) and collagen adhesin (cna). Probably activates the development of biofilm by both enhancing the ica operon transcription and suppressing the transcription of either a protein involved in the turnover of PIA/PNAG or a repressor of its synthesis, whose expression would be sigma-B-dependent.
Similarity
Belongs to the SarA family.
Mass
14.718 kDa
Sequence
MAITKINDCFELLSMVTYADKLKSLIKKEFSISFEEFAVLTYISENKEKEYYLKDIINHLNYKQPQVVKAVKILSQEDYFDKKRNEHDERTVLILVNAQQRKKIESLLSRVNKRITEANNEIEL

Gene
sarA
Protein
Transcriptional regulator SarA
Organism
Staphylococcus aureus (strain MW2)
Length
124 amino acids
Function
Global regulator with both positive and negative effects that controls the expression of several virulence factors and the biofilm formation process in a cell density-dependent manner (By similarity). Required for transcription of primary transcripts RNAII and RNAIII generated by agr (virulence accessory gene regulator) locus. Negatively regulates the expression of spa (protein A) and aur (metalloprotease aureolysin).
Similarity
Belongs to the SarA family.
Mass
14.718 kDa
Sequence
MAITKINDCFELLSMVTYADKLKSLIKKEFSISFEEFAVLTYISENKEKEYYLKDIINHLNYKQPQVVKAVKILSQEDYFDKKRNEHDERTVLILVNAQQRKKIESLLSRVNKRITEANNEIEL

Gene
sarA
Protein
Transcriptional regulator SarA
Organism
Staphylococcus aureus (strain USA300)
Length
124 amino acids
Function
Global regulator with both positive and negative effects that controls the expression of several virulence factors and the biofilm formation process in a cell density-dependent manner.
Similarity
Belongs to the SarA family.
Mass
14.718 kDa
Sequence
MAITKINDCFELLSMVTYADKLKSLIKKEFSISFEEFAVLTYISENKEKEYYLKDIINHLNYKQPQVVKAVKILSQEDYFDKKRNEHDERTVLILVNAQQRKKIESLLSRVNKRITEANNEIEL

Gene
sarA
Protein
Transcriptional regulator SarA
Organism
Staphylococcus aureus (strain NCTC 8325)
Length
124 amino acids
Function
Global regulator with both positive and negative effects that controls expression of several virulence factors and biofilm formation process in a cell density-dependent manner. In a strain-dependent manner plays a role in multidrug resistance mechanism. Is required for transcription of primary transcripts RNAII and RNAIII generated by agr (virulence accessory gene regulator) locus. Acts as a transcriptional activator of the genes encoding, among others, for fibronectin binding proteins (fnbA and fnbB), hemolysins (hla, hld, hlgB and hlgC), serine proteases (splA, splB, splD and splF) and of the bap gene, which is essential for biofilm development in some strains. Negatively regulates the expression of the genes for protein A (spa), lipase (lip), thermonuclease (nuc), immunodominant staphylococcal antigen B (isaB), staphylococcal serine and cysteine proteases (sspA and sspB), staphostatin B (sspC), metalloprotease aureolysin (aur) and collagen adhesin (cna). Probably activates the development of biofilm by both enhancing the ica operon transcription and suppressing the transcription of either a protein involved in the turnover of PIA/PNAG or a repressor of its synthesis, whose expression would be sigma-B-dependent.
Similarity
Belongs to the SarA family.
Mass
14.718 kDa
Sequence
MAITKINDCFELLSMVTYADKLKSLIKKEFSISFEEFAVLTYISENKEKEYYLKDIINHLNYKQPQVVKAVKILSQEDYFDKKRNEHDERTVLILVNAQQRKKIESLLSRVNKRITEANNEIEL

Gene
sarA
Protein
Transcriptional regulator SarA
Organism
Staphylococcus aureus (strain bovine RF122 / ET3-1)
Length
124 amino acids
Function
Global regulator with both positive and negative effects that controls the expression of several virulence factors and the biofilm formation process in a cell density-dependent manner.
Similarity
Belongs to the SarA family.
Mass
14.718 kDa
Sequence
MAITKINDCFELLSMVTYADKLKSLIKKEFSISFEEFAVLTYISENKEKEYYLKDIINHLNYKQPQVVKAVKILSQEDYFDKKRNEHDERTVLILVNAQQRKKIESLLSRVNKRITEANNEIEL

Gene
sarA
Protein
Transcriptional regulator SarA
Organism
Staphylococcus aureus (strain COL)
Length
124 amino acids
Function
Global regulator with both positive and negative effects that controls the expression of several virulence factors and the biofilm formation process in a cell density-dependent manner.
Similarity
Belongs to the SarA family.
Mass
14.718 kDa
Sequence
MAITKINDCFELLSMVTYADKLKSLIKKEFSISFEEFAVLTYISENKEKEYYLKDIINHLNYKQPQVVKAVKILSQEDYFDKKRNEHDERTVLILVNAQQRKKIESLLSRVNKRITEANNEIEL

Gene
sarA
Protein
Transcriptional regulator SarA
Organism
Staphylococcus aureus (strain Newman)
Length
124 amino acids
Function
Global regulator with both positive and negative effects that controls expression of several virulence factors and biofilm formation process in a cell density-dependent manner. In a strain-dependent manner plays a role in multidrug resistance mechanism. Is required for transcription of primary transcripts RNAII and RNAIII generated by agr (virulence accessory gene regulator) locus. Acts as a transcriptional activator of the genes encoding, among others, for fibronectin binding proteins (fnbA and fnbB), hemolysins (hla, hld, hlgB and hlgC), serine proteases (splA, splB, splD and splF) and of the bap gene, which is essential for biofilm development in some strains. Negatively regulates the expression of the genes for protein A (spa), lipase (lip), thermonuclease (nuc), immunodominant staphylococcal antigen B (isaB), staphylococcal serine and cysteine proteases (sspA and sspB), staphostatin B (sspC), metalloprotease aureolysin (aur) and collagen adhesin (cna). Probably activates the development of biofilm by both enhancing the ica operon transcription and suppressing the transcription of either a protein involved in the turnover of PIA/PNAG or a repressor of its synthesis, whose expression would be sigma-B-dependent.
Similarity
Belongs to the SarA family.
Mass
14.718 kDa
Sequence
MAITKINDCFELLSMVTYADKLKSLIKKEFSISFEEFAVLTYISENKEKEYYLKDIINHLNYKQPQVVKAVKILSQEDYFDKKRNEHDERTVLILVNAQQRKKIESLLSRVNKRITEANNEIEL

Gene
sarA
Protein
Transcriptional regulator SarA
Organism
Staphylococcus aureus (strain Mu50 / ATCC 700699)
Length
124 amino acids
Function
Global regulator with both positive and negative effects that controls the expression of several virulence factors and the biofilm formation process in a cell density-dependent manner.
Similarity
Belongs to the SarA family.
Mass
14.718 kDa
Sequence
MAITKINDCFELLSMVTYADKLKSLIKKEFSISFEEFAVLTYISENKEKEYYLKDIINHLNYKQPQVVKAVKILSQEDYFDKKRNEHDERTVLILVNAQQRKKIESLLSRVNKRITEANNEIEL

Gene
sarA
Protein
Transcriptional regulator SarA
Organism
Staphylococcus aureus (strain N315)
Length
124 amino acids
Function
Global regulator with both positive and negative effects that controls the expression of several virulence factors and the biofilm formation process in a cell density-dependent manner.
Similarity
Belongs to the SarA family.
Mass
14.718 kDa
Sequence
MAITKINDCFELLSMVTYADKLKSLIKKEFSISFEEFAVLTYISENKEKEYYLKDIINHLNYKQPQVVKAVKILSQEDYFDKKRNEHDERTVLILVNAQQRKKIESLLSRVNKRITEANNEIEL

Gene
sarA
Protein
Transcriptional regulator SarA
Organism
Staphylococcus aureus (strain MRSA252)
Length
124 amino acids
Function
Global regulator with both positive and negative effects that controls the expression of several virulence factors and the biofilm formation process in a cell density-dependent manner.
Similarity
Belongs to the SarA family.
Mass
14.718 kDa
Sequence
MAITKINDCFELLSMVTYADKLKSLIKKEFSISFEEFAVLTYISENKEKEYYLKDIINHLNYKQPQVVKAVKILSQEDYFDKKRNEHDERTVLILVNAQQRKKIESLLSRVNKRITEANNEIEL