Protein
Serine/threonine-protein phosphatase 6 regulatory subunit
Organism
Caenorhabditis elegans
Function
Regulatory subunit of protein phosphatase 6 (PP6) (Probable). In complex with pph-6, promotes actomyosin contractility during cytokinesis by regulating the organization of cortical non-muscle myosin II nmy-2 and thus contributing to correct spindle positioning (PubMed:20040490). Also required for the proper generation of pulling forces on spindle poles during anaphase by regulating the cortical localization of gpr-1, gpr-2 and lin-5 (PubMed:20040490). Negatively regulates kinase air-1 localization at the cell cortex (PubMed:27335426).
Similarity
Belongs to the SAPS family.
Sequence
MFWAKEEEENSLMRLLKTDNFTLEDVLLNEFVVQESRYGKAELVQYITSRENMKALLELSLNPKINTDLPMKQQYRLSFIASEILTIRGTDVFQKQIVTTEETRKCLVDFLNDKTPLNHLVAGFFAKIMECLLSRHFDLFQTFSLLQETKFFDKCLRNINLGAIECLLENLVRIPTTSEGTRIVKEWMISENLFEKIVDRMRESETDDEKECLAEVYCEILRELRDKLYIMESKVDELHAKSMDETLIAKIADNLIVEEGCPAEELVKKSALISASAKILEAFIKTNFVSNAPAQQLEEIERNLIEERHYSYGLMRPCMDNDPYEHSYQPDPERIVEGILANRLPNILQTVLRDIEANGSVWQPLLRLIIELCNTNCMSTHEKIAVAFRSLPFINLIKAAKMLPRASVLHCLLVKVVILLLHSSFPCDELSPAAEYLLTEGGLIQNIYDTATSPNPGSSVACSGLRSFNQNLGDAINRAKKAGIPNQKLLAILSADNTWTELEDIIHLYNLKHRPQMQHDFNDSSVVSSIRNDSHGFNDSEEWTDASTKFAEMDATSSAKQAFSGFSSPFEPNMQRFSDFEGQFDDTPDEDEFRKLCSERANSSSCAGISFETSPIKWPGEAEKTSEKASEPPSVVASTYPQQTNGNQAFLEQEEGDGEWVWPTVPPLGETEVVTQTGHRPENNWVDETAPDFSHLDMAPPKEDDMWADFSSFPTISPTAAANSASSSSSDAWPGSDIHLQGEASDWPLNNSHESKASDPVMVGLAASISHPGDSSEA