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sap30l

Gene
SAP30L
Protein
Histone deacetylase complex subunit SAP30L
Organism
Homo sapiens
Length
183 amino acids
Function
Isoform 3: Functions as transcription repressor; its activity is marginally lower than that of isoform 1.
Similarity
Belongs to the SAP30 family.
Mass
20.877 kDa
Sequence
MNGFSTEEDSREGPPAAPAAAAPGYGQSCCLIEDGERCVRPAGNASFSKRVQKSISQKKLKLDIDKSVRHLYICDFHKNFIQSVRNKRKRKTSDDGGDSPEHDTDIPEVDLFQLQVNTLRRYKRHYKLQTRPGFNKAQLAETVSRHFRNIPVNEKETLAYFIYMVKSNKSRLDQKSEGGKQLE

Gene
Sap30l
Protein
Histone deacetylase complex subunit SAP30L
Organism
Mus musculus
Length
182 amino acids
Function
Functions as transcription repressor, probably via its interaction with histone deacetylase complexes. Involved in the functional recruitment of the class 1 Sin3-histone deacetylase complex (HDAC) to the nucleolus. Binds DNA, apparently without sequence-specificity, and bends bound double-stranded DNA. Binds phosphoinositol phosphates (phosphoinositol 3-phosphate, phosphoinositol 4-phosphate and phosphoinositol 5-phosphate) via the same basic sequence motif that mediates DNA binding and nuclear import.
Similarity
Belongs to the SAP30 family.
Mass
20.745 kDa
Sequence
MNGFSTEEDSREGPPAAPAAAPGYGQSCCLIADGERCVRPAGNASFSKRVQKSISQKKLKLDIDKSVRHLYICDFHKNFIQSVRNKRKRKASDDGGDSPEHDADIPEVDLFQLQVNTLRRYKRHYKLQTRPGFNKAQLAETVSRHFRNIPVNEKETLAYFIYMVKSNRSRLDQKSEGSKQLE

Gene
sap30l
Protein
Histone deacetylase complex subunit SAP30L
Organism
Xenopus tropicalis
Length
181 amino acids
Function
Functions as transcription repressor, probably via its interaction with histone deacetylase complexes. Involved in the functional recruitment of the class 1 Sin3-histone deacetylase complex (HDAC) to the nucleolus. Binds DNA, apparently without sequence-specificity, and bends bound double-stranded DNA. Binds phosphoinositol phosphates (phosphoinositol 3-phosphate, phosphoinositol 4-phosphate and phosphoinositol 5-phosphate) via the same basic sequence motif that mediates DNA binding and nuclear import.
Similarity
Belongs to the SAP30 family.
Mass
20.862 kDa
Sequence
MNGFSTEEDSRDGPPAQAAPFFGQTCCLIDGGERCPRPAGNASFSKRVQKSISQKKLKLDIDKSVRHLYICDFHKNYIQSVRNKRKRKTSDDGGDSPEHETDVPEVDLFQLQVNTLRRYKRYYKLQTRPGLNKAQLAETVSRHFRNIPVNEKETLAYFIYMVKSNRSRLDQKSESSKQLEA

Gene
sap30l
Protein
Histone deacetylase complex subunit SAP30L
Organism
Danio rerio
Length
178 amino acids
Function
Functions as transcription repressor, probably via its interaction with histone deacetylase complexes (PubMed:22821512). Required for normal expression of numerous target genes (PubMed:22821512). Involved in the functional recruitment of the class 1 Sin3-histone deacetylase complex (HDAC) to the nucleolus. Binds DNA, apparently without sequence-specificity, and bends bound double-stranded DNA. Binds phosphoinositol phosphates (phosphoinositol 3-phosphate, phosphoinositol 4-phosphate and phosphoinositol 5-phosphate) via the same basic sequence motif that mediates DNA binding and nuclear import (By similarity).
Similarity
Belongs to the SAP30 family.
Mass
20.589 kDa
Sequence
MNGFSTEEDSHDGPPAPPFFGQSCCLIEDAERCGRPAGNASFSKRIQKSISQRKLKLDIDKSVRHLYICDFHKNFIQSVRNKRKRKTSDDGGESPDHEVEVPEVDLFQLQVNTLRRYKRHYKIQTRPGLNKAQLAETVSRHFRNIPVNEKETLTYFIYMVKSSKSRLDQKSDSSKQVE