Protein
Serine-protein kinase RsbW
Organism
Bacillus licheniformis (strain ATCC 14580 / DSM 13 / JCM 2505 / NBRC 12200 / NCIMB 9375 / NRRL NRS-1264 / Gibson 46)
Function
Negative regulator of sigma-B activity. Phosphorylates and inactivates its specific antagonist protein, RsbV. Upon phosphorylation of RsbV, RsbW is released and binds to sigma-B, thereby blocking its ability to form an RNA polymerase holoenzyme (E-sigma-B).
Similarity
Belongs to the anti-sigma-factor family.
Sequence
MKRAADYIEMKSPAKPEYVGIIRLTLSGIASKMGYSYDDIEDLKIAVSEACTNAVQHAYKADNNTGEVSVRFGVFEDRLEIVVADQGDSFDIQDKQKELGPYSPEHTVDQLSEGGLGLYLMETLMDEVHVQIDSGVTVSMTKFLNRERVDDGTTVQNYETN