Protein
1,3,6,8-tetrahydroxynaphthalene synthase
Organism
Streptomyces peucetius subsp. caesius
Function
Involved in the biosynthesis of melanin but also various secondary metabolites containing a naphthoquinone ring. Catalyzes the iterative condensation of five CoA-linked malonyl units to form a pentaketide intermediate. THNS subsequently catalyzes the dual intramolecular Claisen and aldol condensations of this linear intermediate to produce the fused ring of 1,3,6,8-tetrahydroxynaphthalene (THN).
Similarity
Belongs to the thiolase-like superfamily. Chalcone/stilbene synthases family.
Sequence
MRVPVAVDDLVAPSTMGERHTVIDRGTSVAAVHTALPPHRYAQSDLTELIADLCLEPGADRALLRRLHTSAGVRTRHLALPIEQYAGLGDFGQANAAWLTVGLALAEEALSGALDAAGLTAADIDLLVCTSITGVAAPSLDARLAVRMGMRADVKRVPVFGLGCVGGAAGLGRLHDYLLGHPDDTAVLLSVELCSLTLQRDGSLANLVAGALFGDGAAAVVARGGDAGRRGAGWPMVAATRGHLYPDTEHLLGWRIGASGFRVVVDAGIPDVVRTHLGGDLRNFLATHGLVPDDIGTWICHPGGPKVLAAVGDALELPDGALDSSWRSLAGVGNLSSASVLRVLEDVATRCRPDPGTWGVLLAMGPGFCAEFVLLRW