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rpn15

Gene
rpn15
Protein
26S proteasome complex subunit rpn15
Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Length
71 amino acids
Function
Versatile protein that might stabilize multiple protein complexes involved in diverse pathways. Subunit of the 26S proteasome which plays a role in ubiquitin-dependent proteolysis (PubMed:16149916). Acts as a ubiquitin receptor of the 26S proteasome, by interacting with ubiquitin chains linked by 'Lys-63' and 'Lys-48' (PubMed:25306921). Involved in nuclear export of specific sets of mRNAs (PubMed:18023413). Links the mRNA adapter mlo3 to rae1 for targeting mRNA-protein complex to the proteins of the nucleoporin complex (NPC) (PubMed:15990877). Involved in recombinational repair of DNA. Plays a critical role in linking repair and checkpoint factors to damaged DNA sites by specifically recruiting rad24 and cdc25 to the DSBs (PubMed:20231270).
Similarity
Belongs to the DSS1/SEM1 family.
Mass
8.111 kDa
Sequence
MSRAALPSLENLEDDDEFEDFATENWPMKDTELDTGDDTLWENNWDDEDIGDDDFSVQLQAELKKKGVAAN