Protein
Ribonuclease P protein component 3
Organism
Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)
Function
Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. The RNA is catalytic, but its KM for pre-tRNA is 170-fold decreased in the presence of the 4 known protein subunits (Rnp1-4). The protein subunits also decrease the amount of Mg(2+) needed for activity.
Similarity
Belongs to the eukaryotic/archaeal RNase P protein component 3 family.
Sequence
MAGGRNGVKFVEMDIRSREAYELAEEWFDDVVFSYEIPPGVLDKERLKEIKKEYGNVAITLINPKPSLVKEAVQRFKQNYLIYVESSDLRVVRYSIERGVDAVISPWANRKDQGIDHVLARMMNKRGVALGFSLRPLLHQNPYERANALKFMRKAWTLVNKYKVPRFISSSAKGKFQVRGVKELISLGIAIGMEEVQAKASLSFYPLGILERLK