RNF19B

E3 ubiquitin-protein ligase RNF19B

732 amino acids

E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates, such as UCKL1 (PubMed:16709802, PubMed:27485036). Involved in the cytolytic activity of natural killer cells and cytotoxic T-cells (PubMed:10438909). Protects against staurosporin-induced cell death (PubMed:27485036).

Belongs to the RBR family. RNF19 subfamily.

77.925 kDa

MGSEKDSESPRSTSLHAAAPDPKCRSGGRRRRLTLHSVFSASARGRRARAKPQAEPPPPAAQPPPAPAPAAAQGPPPEALPAEPAAEAEAEAAAAAAEPGFDDEEAAEGGGPGAEEVECPLCLVRLPPERAPRLLSCPHRSCRDCLRHYLRLEISESRVPISCPECSERLNPHDIRLLLADPPLMHKYEEFMLRRYLASDPDCRWCPAPDCGYAVIAYGCASCPKLTCEREGCQTEFCYHCKQIWHPNQTCDMARQQRAQTLRVRTKHTSGLSYGQESGPADDIKPCPRCSAYIIKMNDGSCNHMTCAVCGCEFCWLCMKEISDLHYLSPSGCTFWGKKPWSRKKKILWQLGTLIGAPVGISLIAGIAIPAMVIGIPVYVGRKIHSRYEGRKTSKHKRNLAITGGVTLSVIASPVIAAVSVGIGVPIMLAYVYGVVPISLCRGGGCGVSTANGKGVKIEFDEDDGPITVADAWRALKNPSIGESSIEGLTSVLSTSGSPTDGLSVMQGPYSETASFAALSGGTLSGGILSSGKGKYSRLEVQADVQKEIFPKDTASLGAISDNASTRAMAGSIISSYNPQDRECNNMEIQVDIEAKPSHYQLVSGSSTEDSLHVHAQMAENEEEGSGGGGSEEDPPCRHQSCEQKDCLASKPWDISLAQPESIRSDLESSDAQSDDVPDITSDECGSPRSHTAACPSTPRAQGAPSPSAHMNLSALAEGQTVLKPEGGEARV

Rnf19b

E3 ubiquitin-protein ligase RNF19B

732 amino acids

E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates, such as UCKL1. Involved in the cytolytic activity of natural killer cells and cytotoxic T-cells. Protects against staurosporin-induced cell death (By similarity).

Belongs to the RBR family. RNF19 subfamily.

78.127 kDa

MGSEKDSESPRSTSLHAAAPDPKCRSGGRRRRLTFHSVFSASARGRRARTKPQAEPPPPAAPPPPPPPAPAPVEAQAPPVEALPSEPAAEAEAEAVAAGPEEDEAAEGGGAEEVECPLCLVRLPPERAPRLLSCPHRSCRDCLRHYLRLEISESRVPISCPECSERLNPHDIRLLLADPPLMHKYEEFMLRRYLASDPDCRWCPAPDCGYAVIAYGCASCPKLTCEREGCQTEFCYHCKQIWHPNQTCDMARQQRAQTLRVRTKHTSGLSYGQESGPADDIKPCPRCSAYIIKMNDGSCNHMTCAVCGCEFCWLCMKEISDLHYLSPSGCTFWGKKPWSRKKKILWQLGTLIGAPVGISLIAGIAIPAMVIGIPVYVGRKIHSRYEGRKTSKHKRNLAITGGVTLSVIASPVIAAVSVGIGVPIMLAYVYGVVPISLCRGGGCGVSTANGKGVKIEFDEDDGPITVADAWRALKNPSIGESSIEGLTSVLSTSGSPTDGLSVMQGPYSETASFAALSGGTLSGGILSSGKGKYSRLEVQADVQKEIFPKDTASLGAISDSASTRAMAGSIISSYNPQDRECNNMEIQVDIEAKPSHYQLVSGSSTEDSLHVHAQVAEKEEEGNGAGGGSGGSEDDPPYKHQSCEQKDCLASKAWDISLAQPESIRSDLESSDTQSDDVPDITSDECGSPRSHAAACPSTPQVHGAPSPSAHKNLAAPAEGQTVLKSEEYEVE

rnf19b

E3 ubiquitin-protein ligase RNF19B

701 amino acids

E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates, such as UCKL1. Involved in the cytolytic activity of natural killer cells and cytotoxic T-cells. Protects against staurosporin-induced cell death.

Belongs to the RBR family. RNF19 subfamily.

74.943 kDa

MGSEKDSESPHSSVSGIPNPKCRGPGKKQGRISFHSLFHSKRGPRGSKANVGTPLAQQLHQQQQIQQQQLLQPPTPTNVSSDPSTADPAEPLSTSQASLGGQELLECPLCLVRQPAEQLPELQGCSHRSCLCCLRQYLRIEITESRVQLSCPECAERLAPWQVALILDDPNLMEKYEEFLLRRCLASDPDCRWCPAPDCGFAVIASGCASCPRLVCRREGCGAEFCYHCKQAWHPNQTCDSARQQRALSLRTHSNHSPSYTAEQGHTDDIKPCPRCGAYIIKMNDGSCNHMTCAVCGCEFCWLCMKEISDLHYLSPSGCTFWGKKPWSRKKKILWQLGTLIGAPVGITLIAGIAVPAMVIGIPVYIGRKIHSHYEGKKTSHHRRNLAITGGVALSIITAPVIAAVSVGIGVPIMLAYVYGVVPISLCRGGGCGVSRGKGRGVRIDFDEDDGPITVADAWRALKSPSLGESSLEGAASGLSTTSPSEGLSVAPGGLGDTPHFNTLAGGALGARTGKYSRLEVQGTELGKEVAGRETGSLGAASDCASTRGMAGSITSSYTLPDREGTNLEIQVDIETKPSHLCLTTEEDLAPPTAAMAPGVGEEPQDCSSRRSRTVMDSPLGLSPGMSLREGLRDVTLAQPESIRSDLEMSDTQSDDIAELTSDDCDSPHPKSCHGAPPQATCRALNPTDSLHCPDNVILYV

rnf19b

E3 ubiquitin-protein ligase RNF19B

687 amino acids

E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates, such as UCKL1. Involved in the cytolytic activity of natural killer cells and cytotoxic T-cells. Protects against staurosporin-induced cell death (By similarity).

Belongs to the RBR family. RNF19 subfamily.

74.541 kDa

MRLRNDCLVRLLTSWFGIFCLYEMTEGSAEPPPCPGARRRRLLLSLPNVFPGRTRAAPEPSVPSPPPSPPPPPPPPVSVPPPPSSPGGSESLIECPLCLVRQPPEEIPELLSCRHRSCLRCLRQYLRIEICESRVNLRCPECAERLSPQHVRAILRDPLLTRKYEEFLLRRCLAADPDCRWCPAPDCGYAVIAYGCASCPKLTCEREGCRTEFCYHCKHVWHPNQTCDMARQQRAPSLGVRRKHPSGISYGQESGSADDMKSCPRCSAYIIKMNDGSCNHMTCSVCGCEFCWLCMKEISDLHYLSPSGCTFWGKKPWSRKKKIIWQLSTLIGAPVGISLIAGIAIPAMVIGIPVYVGRKIHGRFENKKTSRHKKNLAVTGGVILSVIASPVVAAVSVGIGVPIMLAYVYGVVPVSLCRGGGCGVTTANGKGVKIDFEEDGPITVADAWRALKNPSIGESSMEGLTSVLSTSGSPTDGLSVLQGNYSETASFAALAGGTLTGGMLSGGRAKYCRLEVQADVQKETCQKDSVSLGAVSDSASTRAMAGSIISSYNPQEREVNNMEIQVHIEAKPSRYQLMSESSTEESLHASAPLVESEDAEACRNQVAACDITLAQPESIRSDLESSDAQSDDVPDLASEEYDSPHLFPPSPSNALQESPPHRMCAQEEGLCAHEESLSKVEIIELRV