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rnf157

Gene
Rnf157
Protein
E3 ubiquitin ligase Rnf157
Organism
Mus musculus
Length
685 amino acids
Function
E3 ubiquitin ligase that ubiquitinates APBB1 for its degradation by the proteasome and thus prevents apoptosis and promotes survival of neurons (PubMed:25342469). Has a dual role in neurons as it is also required for dendrite growth and maintenance for which its ligase activity is not critical (PubMed:25342469). May act as a scaffold molecule to regulate this process (PubMed:25342469). Acts as a downstream effector of the interconnected PI3K and MAPK signaling pathways and thus participates in the regulation of the cell cycle (By similarity).
Mass
74.534 kDa
Sequence
MGALTSRQHAGVEEVDIPSNSVYRYPPKSGSYFASHFIMGGEKFDSTHPEGYLFGENSDLNFLGNRPVAFPYAAPPPQEPVKTLRSLINIRKDTLRLVKCAEEVKSHGEEAGKAKVHYNVEFTFDTDARVAITIYYQATEEFQNGIASYIPKDNSLQSETVHYKRGVFQQFCLPSHTVDPSEWAEEELGFDLDREVYPLVVHAVVDEGDEYFGHCHVLLGTFEKHPDGTFCVKPLKQKQVVDGVSYLLQEIYGIENKYNTQDSKVAEDDVSDNSAECVVCLSDVRDTLILPCRHLCLCNTCADTLRYQANNCPICRLPFRALLQIRAMRKKLGPLSPSSFNPIISSQTSDSEEHSSSENIPPGYEVVSLLEALNGPLTSSPAVPPLHVLGDGHLSGMLPSYGSDGYLPPVRTLSPLDRLSDCNNQGLKLKKSLSKSISQNSSVLHEEEDERSCSESDTQLSQRLSVQHPEEGPDVTPESENLTLSSSGAVDQSSCTGTPLSSTISSPEDPASSSLAQSVMSMASSQISTDTVSSMSGSYIAPGTEEEGEALPSPRAASRAPSEGEETPAESPDSNFAGLPAGEQDAEGNDIIEEEDRSPVREDGQRTCAFLGMECDNNNDFDVASVKALDNKLCSEVCLPGEWQCAEHELGGRRPSARPRSPRGGLGKEASAFRIETVALPGTYV

Gene
Rnf157
Protein
E3 ubiquitin ligase Rnf157
Organism
Rattus norvegicus
Length
682 amino acids
Function
E3 ubiquitin ligase that ubiquitinates APBB1 for its degradation by the proteasome and thus prevents apoptosis and promotes survival of neurons (By similarity). Has a dual role in neurons as it is also required for dendrite growth and maintenance for which its ligase activity is not critical (By similarity). May act as a scaffold molecule to regulate this process (By similarity). Acts as a downstream effector of the interconnected PI3K and MAPK signaling pathways and thus participates in the regulation of the cell cycle (By similarity).
Mass
74.565 kDa
Sequence
MGALTSRQHAGVEEVDIPSNSVYRYPPKSGSYFASHFIMGGEKFDCTHPEGYLFGENSDLNFLGNRPVSFPYAAPPPHEPVKTLRSLINIRKDTLRLVKCAEEVKSHGEEAGKAKVHYNVEFTFDTDARVAITIYYQATEEFQNGIASYIPKDNSLQSETVHYKRGVCQQFCLPSHTVDPSEWAEEELGFDLDREVYPLVVHAVVDEGDEYFGHCHVLLGTFEKHSDGTFCVKPLKQKQVWDGVTYLLQEDYGIENKSNTQDFKVAEDDVRDNSAECVVCLSDVRDTLILPCRHCASCNVHCADTLRYQANNCPICRLPFRALLQIRAMRKKLGPLSPSSFNPIISSQTSDSEEHSSSENIPAGYEVVSLLEALNGPLTSSPAVPPLHVLGDGHLSGMLPSYGSDGHLPPVRTLSPLDHLSDCNSQGLKLNKSLSKSISQNSSVLHEEEDERSCSESDTQLSQRLSAQHPEEGPDVTPESENLTLSSSGAVDQSSCTGTPLSSTISSPEDPASSSLAQSVMSMASSQISTDTVSSMSGSYIAPGTEEEGEAPPSPRAASRAPSEEEETPAESPDSNFAGLPAGEQDAEGNDIMEEEDRSPVQEDGQRTCAFLGMECDNNNDFDVASVKALDNKLCSEVCLPGTWQHDAAIINRHNTQRRRLSPSSLEDPEEDRPCVWDPLAV

Gene
RNF157
Protein
E3 ubiquitin ligase RNF157
Organism
Homo sapiens
Length
679 amino acids
Function
E3 ubiquitin ligase that ubiquitinates APBB1 for its degradation by the proteasome and thus prevents apoptosis and promotes survival of neurons (PubMed:25342469). Has a dual role in neurons as it is also required for dendrite growth and maintenance for which its ligase activity is not critical (PubMed:25342469). May act as a scaffold molecule to regulate this process (PubMed:25342469). Acts as a downstream effector of the interconnected PI3K and MAPK signaling pathways and thus participates in the regulation of the cell cycle (PubMed:28655764).
Mass
73.579 kDa
Sequence
MGALTSRQHAGVEEVDIPSNSVYRYPPKSGSYFASHFIMGGEKFDSTHPEGYLFGENSDLNFLGNRPVVFPYAAPPPQEPVKTLRSLVNIRKDTLRLVKCAEEVKSPGEEASKAKVHYNVEFTFDTDARVAITIYYQATEEFQNGIASYIPKDNSLQSETVQYKRGVCQQFCLPSHTVDPSEWAEEELGFDLDREVYPLVVHAVVDEGDEYFGHCHVLLGTFEKHTDGTFCVKPLKQKQVVDGVSYLLQEIYGIENKYNTQDSKVAEDEVSDNSAECVVCLSDVRDTLILPCRHLCLCNTCADTLRYQANNCPICRLPFRALLQIRAMRKKLGPLSPTSFNPIISSQTSDSEEHPSSENIPPGYEVVSLLEALNGPLTPSPAVPPLHVLGDGHLSGMLPSYGSDGHLPPVRTISPLDRLSDSSSQGLKLKKSLSKSTSQNSSVLHEEEDEHSCSESETQLSQRPSVQHLGEECGVTPESENLTLSSSGAIDQSSCTGTPLSSTISSPEGPASSSLAQSVMSMASSQISTDTVSSMSGSYIAPGTEEEGEALSSPQPASRAPSEEGEGLPAESPDSNFAGLPAGEQDAEGNDVIEEEDGSPTQEGQRTCAFLGMECDNNNDFDIASVKALDNKLCSEVCLPGAWQADDNAVSRNAQRRRLSSSSLEDSETRPCVWGPLAV

Gene
rnf157
Protein
E3 ubiquitin ligase Rnf157
Organism
Xenopus laevis
Length
674 amino acids
Function
E3 ubiquitin ligase that ubiquitinates apbb1 for its degradation by the proteasome and thus prevents apoptosis and promotes survival of neurons (By similarity). Has a dual role in neurons as it is also required for dendrite growth and maintenance for which its ligase activity is not critical (By similarity). May act as a scaffold molecule to regulate this process (By similarity). Acts as a downstream effector of the interconnected PI3K and MAPK signaling pathways and thus participates in the regulation of the cell cycle (By similarity).
Mass
73.258 kDa
Sequence
MGALASRQHAGVEEMDMPCNSLYRYPPKSGSYFGSHFIMGGEKFESSHPEGYLFGENSDLNFLGSRPVTFPYTAPSPQEPVKTLRSLINIRKDTLRLVRCTEELKTTGVEGSRPKVHYNVEFTFDTDARVAITMYYQATEEFQGGIPSYLPKSSNLQSDTVHFKRGVSQQFCFPSHTVDPSEWREEELTFDLDREVYPMVVHAVVEEGEEHLGHSHVLMATFEKHADGSFCVKPLKQKQVVDGVSYLLQEIYGIENKYNSQDSKVAEDELSDNSAECVVCLSDVRDTLILPCRHLCLCNACADTLRYQASNCPICRLPFRALLQIRAMRKVPGPHSPGGFSPIIAAPTSDSEEHTSEHVPPGYEVVSLLEALNGPLTPSPSAPPLRALGEARRPGGLPSYGSDIHLRMHSPLQHLCGGQALKLKKSISRSISQNSSVLQEDEMEKSFSEAEIQTPRKKTSQLAEENGVTPESENLTLSSSGAIDQSSCTGTPLSPTISSPEDPLSSSLAQSIMSMASSHSQQSQLSTDTVSSMSGSYTAGGMEEEEGGITPSPPAAASGSPSIEGELSPAESPEPHFVTVSAEEMDAEGNVTEEEFASPEEDDGQMTGRECDNNNAAGVTLRDVLDNVRGSEGCLADVCYSSIPGQQRSNPYHGSDNCISLQDDTQSHLSTKLV