Protein
Receptor-mediated endocytosis protein 6
Organism
Caenorhabditis briggsae
Function
Acts both as a GTPase-activating protein (GAP) and a guanine nucleotide exchange factor (GEF), and participates in endocytosis. Acts by regulating the activation of rab-5 by exchanging bound GDP for free GTP at clathrin coated pits (By similarity).
Similarity
Belongs to the GAPVD1 family.
Sequence
MSEAVEKIRSHDKYRQFYELATKIRNQKLLADAESASLHRHKQEVADLEVKLLTEAWRSSYWTNVSRQLKSQSLDPSYACRLLKEISDTEALAAYKHFGHHYSTLNQLLTVLYMEPTSVAELLNMWDQNDVTTNDNLIQTFFHLVYSCGLYPDDELKIAQVVCYLLKLQLVKSGSQMRTMLRKETSISTRFYKYFVEQMHPTMVYLTKALRKSVLNVIQLGNFWLDVDMKQSSSRFLSDGRQNSERLPEYRALVVSKLVDFVDNFLENISLALSMLPPNLNWIVRDIFCSLYEIVDDMSAIELSHACKDMIVSNLLCPAIISPQKFGVVDNDVRIGSIVNHNLAQIAMIIQMISLREFESPPEEYREFLSQCRNTHLISEMMDSLLVENMAPDVEITSLIASGKSESDLETKSNFVGSLADANKLIKMIRETPPTTDLKISRIVSVCQKMPESFASTVEKLHVENSEDSPKLSALRNIHRKVQKSFKRTGDSFYDPNELHMKTENYGGVFEKENFDRKLREASEVERRKQEARKQKQLKETELLIMDNISSDSAPITIKASAATNAPIANNNFTENKDLIDFSTLYTTTDDVISIPSEPSKEEKSVEKPNVNNVSVDAPVEALQIGESRGGLAKLKNFSDRMKKGITQSNTLSDIRDHLRRSSSLAKQPSGMVSSASAQNIPDTEKGDSILAKYASNSSIKIEKSTFTKLTDTKSMPKNTEMSEPYYSPENLTSCRAFKDTLRKMITVLGNVSYLPKIGCRSEMKEMSKKVRLDSFLDGVLVETEHRREYGQAAQLREVKRCIELFENEGVEILMDHLVGNEVEQDFLVRQMREERAILMRKSNDISSMEQRVLLNRRLTEQILVDNLIQTFLETGFQNSKLASGKTPEVVAVGKFYSEFKFLQAHDERAEFLQNLLTYLRERLMQNYDWNFATESMIARAMTTMERFVMFAVYEIAFWPNREMDQKKDKLLQSVIGKASSSVTPVHEALKIPEHLLGEAPWPSAQAELSMLDNYVTAQEKLNCLVRCCDVINNLVALSSKNAVASADDLTPVLVFVIIKANPRSLLSNLQFIETFAGDQIESGRDAYYWVNFKSAVEYIKTIL