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rib-1

Gene
rib-1
Protein
Exostosin-1 homolog
Organism
Caenorhabditis elegans
Length
382 amino acids
Function
Required for the biosynthesis of heparan sulfate by positively regulating N-acetylglucosamine transferase II (GlcNAcT-II) and glucuronyl transferase II (GlcAT-II) activities of glycosyltransferase rib-2 (PubMed:17237233). Probably not directly involved in chondroitin sulfate biosynthesis but negatively regulates chondroitin sulfate levels (PubMed:16828468, PubMed:17237233). Maternally required for normal ventral epidermal enclosure and for embryo elongation during the early stages of embryonic development (PubMed:17237233). In addition, involved in the elongation of the pharyngeal isthmus and in the organization of the actin cytoskeleton in the pharyngeal muscles during the later stages embryonic development (PubMed:16828468). In adults, regulates egg-laying and the normal morphogenesis of the vulva (PubMed:17237233). Also involved in the directed migration of hermaphrodite-specific neurons (PubMed:17237233, PubMed:24052309).
Similarity
Belongs to the glycosyltransferase 47 family.
Mass
44.926 kDa
Sequence
MQNVMKFHLVIFMLFGSVRLQNPTIERKQCTMSNCFDFSKCSTSKKVYIHPMEKRFEESPQSVIYSKILKHFLESNHYTNDPNEACIFLLGIDTTDRDVRSQNYVKNVNDYIESLDPSVWNNGRNHLIFNFYHGTFPDYDDHNLNFDTGEAMIARASSSENNFIKVFDVSLPLFHENHPYEIKESKSERNDDRIENQRKYLVSFKGKRYVYGIGSGTRNLVHHLHNGDDIVMVTTCKHNNDWQVYQDDRCQRDNDEYDRWEYDELLANSTFCLVPRGRRLGSFRFLETLRSGCVPVVISDSWILPFSETIDWNSAAIVVAERDALSIPELLMSTSRRRVKELRESARNVYDAYLRSIQVISDHVLRIIFKRIDNKIELEDHQ