rhsA

Probable deoxyribonuclease RhsA

1434 amino acids

Toxic component of a toxin-immunity protein module, which functions as a cellular contact-dependent growth inhibition (CDI) system. This protein may be a nuclease that is specifically inhibited by its cognate immunity protein RhsAI. Upon expression of the C-terminus (residues 1284-1434) in E.coli growth is inhibited, cells elongate, nucleoids condense and plasmid DNA is degraded; these effects are blocked specifically by cognate immunity protein RshIA. Cell contact is necessary for growth inhibition.

Belongs to the RHS/WapA nuclease family.

160.78 kDa

MLNDILSRVARVGAMHAGNRPNPPDDRPQPCRGKPPTSPGKTIKHKSFLGALAGAVAGALVAAAVAAAAVFLVGVTGGLAVAAVGALAVFAAGDLISAVTNKVSAMVDSASPAFGPVASGSGNVFVEKQPVARATKDTVACTKHNSPQLIAQGSESVFVNDAPAARIDDKTVCGATVKEGASTVFFGSGQGTYLDIADEFSWWEKALLIAVEFLVPPSRGMLKGLGKLFIRGPKAVLRGSRAGAKWIAGRLADKSSCASKAFKASSGLTRAKAAVKAFLKDPVYIASGEVIESRTDIELGQTLPLAFERTYRSASVHIGLLGRGWHDSWSEVATVTRDGLNTHVVITLAQGYDIDFTFHQDVQAVYCPHYPEFTLHRRGDGFSLWHRDQQTWRDFSVVQGERRLLSAIHDSHDNRIELVRDPKGYLRQVRHSDGVTLLLVWQGEFLHQIQRIDGGQKTLLAEYRQDEQGRLVEANATQAYHLYYDYDAAHRLTRWHDNDQTWARYEYDAQGRCVYTTCADGFLTARFDYLPDRVVMTDGLGQCSEFGFNDLFLMSWEKSPLGHVTRYEYDDYGNLLREISPAGRVVEFTYLDDTGRVSTFTDASGHQWQYDYDAAQRLCGVTDPLGREWGWMYDAEGNPERLTGPDASEVRFTWNRYGLLTQVSDAAGEVQARLQYDHRQRLLSATDAESRTRQLRYDGQDRVVQWQRADGARFRLGYRRASWTLPEQLIRPDDKEEQRQYDRHNNLLSYVDGNGALWRQTFGPFDLLTARTDAEGRTWHYAYDKESQQLTTVIAPDGSHWQWWLDADGRVIRERDMTGTETHYDYDEDGLCIRVRNGEGDTRHFLYDARGLLLRETAPDDTLHYRYDAVGRLTEVSSSTAHVQLEYDLRDRMVREWHNGTLLTRQVDDAARTVTRTLTWDGDADDTINALAPLTSLFHYTRTGELRQVQLPDGADLTLTHDAAGRESHRTGGSGFVQQREYDVMGWLTREMSGAQHDGHLLATQTREYRYDGAGNLTGVRHNRDAEGYRLDATGRVQEILSGGAGKPVDTTARFLYTRTGLPQEAGRLTEWQAGRLVQHDDTHYQYDRAGRLIRKQVVQPGYRPQVWQYRWDSRNQLRVVDTPNGERWLYRYDPFGRRVGKRCDQKAEEIRYLWDGDQIAEIRHYRHGQLIQRRHWVYNGWELVVQQRQHTGGDWETDFVTSSQNGTPQALFTPDGTLRWQAPKATLWGQRQAEKSESPDPGLAFAGQLRDSESGLCYNRFRYYDPAGGCYVSPDPIGIAGGESNYGYVSNPMCWVDPFGLAKCPTLAHGANGEILSAKATVSKAELRTGSGTNQSSRDYARSLGNQTDDAGHILGNVLGGQGGKGNVFPQLPAINRGQYRDFEKVVKDYIGQHGSVDIEWAFKYGNGGTRPTEIYYDVYQNGQKVFGRIFNN

rhsA

Protein RhsA

1377 amino acids

Rhs elements have a nonessential function. They may play an important role in the natural ecology of the cell.

Belongs to the RHS family.

156.321 kDa

MSGKPAARQGDMTQYGGSIVQGSAGVRIGAPTGVACSVCPGGVTSGHPVNPLLGAKVLPGETDIALPGPLPFILSRTYSSYRTKTPAPVGSLGPGWKMPADIRLQLRDNTLILSDNGGRSLYFEHLFPGEDGYSRSESLWLVRGGVAKLDEGHRLAALWQALPEELRLSPHRYLATNSPQGPWWLLGWCERVPEADEVLPAPLPPYRVLTGLVDRFGRTQTFHREAAGEFSGEITGVTDGAWRHFRLVLTTQAQRAEEARQQAISGGTEPSAFPDTLPGYTEYGRDNGIRLSAVWLTHDPEYPENLPAAPLVRYGWTPRGELAVVYDRSGKQVRSFTYDDKYRGRMVAHRHTGRPEIRYRYDSDGRVTEQLNPAGLSYTYQYEKDRITITDSLDRREVLHTQGEAGLKRVVKKEHADGSVTQSQFDAVGRLRAQTDAAGRTTEYSPDVVTGLITRITTPDGRASAFYYNHHNQLTSATGPDGLELRREYDELGRLIQETAPDGDITRYRYDNPHSDLPCATEDATGSRKTMTWSRYGQLLSFTDCSGYVTRYDHDRFGQMTAVHREEGLSQYRAYDSRGQLIAVKDTQGHETRYEYNIAGDLTAVIAPDGSRNGTQYDAWGKAVRTTQGGLTRSMEYDAAGRVIRLTSENGSHTTFRYDVLDRLIQETGFDGRTQRYHHDLTGKLIRSEDEGLVTHWHYDEADRLTHRTVKGETAERWQYDERGWLTDISHISEGHRVAVHYRYDEKGRLTGERQTVHHPQTEALLWQHETRHAYNAQGLANRCIPDSLPAVEWLTYGSGYLAGMKLGDTPLVEYTRDRLHRETLRSFGRYELTTAYTPAGQLQSQHLNSLLSDRDYTWNDNGELIRISSPRQTRSYSYSTTGRLTGVHTTAANLDIRIPYATDPAGNRLPDPELHPDSTLSMWPDNRIARDAHYLYRYDRHGRLTEKTDLIPEGVIRTDDERTHRYHYDSQHRLVHYTRTQYEEPLVESRYLYDPLGRRVAKRVWRRERDLTGWMSLSRKPQVTWYGWDGDRLTTIQNDRTRIQTIYQPGSFTPLIRVETATGELAKTQRRSLADALQQSGGEDGGSVVFPPVLVQMLDRLESEILADRVSEESRRWLASCGLTVEQMQNQMDPVYTPARKIHLYHCDHRGLPLALISKEGTTEWCAEYDEWGNLLNEENPHQLQQLIRLPGQQYDEESGLYYNRHRYYDPLQGRYITQDPIGLKGGWNFYQYPLNPVTNTDPLGLEVFPRPFPLPIPWPKSPAQQQADDNAAKALTKWWNDTASQRIFDSLILNNPGLALDITMIASRGNVADTGITDRVNDIINDRFWSDGKKPDRCDVLQELIDCGDISAKDAKSTQKAWNCRHSRQSNDKKR