rgy2

Reverse gyrase 2

1233 amino acids

Modifies the topological state of DNA by introducing positive supercoils in an ATP-dependent process. It cleaves transiently a single DNA strand and remains covalently bound to the 5' DNA end through a tyrosine residue. May be involved in rewinding the DNA strands in the regions of the chromosome that have opened up to allow transcription or replication.

In the C-terminal section; belongs to the prokaryotic type I/III topoisomerase family.

141.175 kDa

MNTIPSSNYLSSCPNCGRVISAERLYKGSVCSECLEEDREFNSIRELVNELSRLNKLNRLNYIKEVLREYDIFVELFKRIIGFPPFGPQKSWIIRVLRKESFAIIAPPGLGKTTFGIITSLYFSSKNFRSILIFPTRSLVKQAVDRISMYSNKTNIETKLLYYHSGINESQKQELYKALNAGDFNIFIATNRFFIDKINELKNIKYDFMFVDDVDTALKSSKSAETILNLAGFSKDDILSVKELLRKSREDESVYTKIQEIRGNKLKGKTIVFSSATLTRGNPVLSALMGFRPGSSVIYLRKIIDTYAYLPNNDDDVVNLLKELLNKLGEGGLIFVPVDKGQEYAKFLEAKLSDSFNVVTITSSNTNKIEDFANGNIYALIGSATHYGILVRGIDIPWRVKYAIFVGIPKFKFKIGEVMNLVALSRILSMIGLITKDQDIVRLAGRVRGKLRKLSPAAISMLTNQAREGKLEDETLLRAYEVVNKYLEDKDILKKIAELGDLVISNGYILMPDYLTYIQASGRTSRIYGGELTTGLSVLLIDDINLFNILNRKLSLILDEIIWQELQIKKNKIGSSDLTEIINKINEERERILKVKKEGEIEPSLQKVKTVLFIVESPNKAKTISNFFAKPSIRQLENIRAFETVLEDKILIVAATGGHVYDLTTQNIGIYGVEVQQQNSHFNFIPYYNTIKKCINGHQFTDFEQGNQCPKCHTTQIILDKTATIDALRKLALEADEILIGTDPDTEGEKIAWDIYLALKPFNSNIKRAEFHEVTRKAILQAINNPRPFNVNLVKSQIVRRIEDRWIGFKLSTKLQEDFWKEYCKNYNCKSEENKNLSAGRVQSPVLNWIVNRYDEYNANKTKIYYGSIKGIDELKFYVFKQNEKIRKNANIYVKIINTKVLEEEINPLPPYTTDTLLYDANQFYGISASETMKIAQDLFELGLITYHRTDSTRISNTGISIAEGYLKQIAGENYTKIFKPRSWGEGGAHEAIRPTRPLDVDQLRLLVDEGEIELAKKITRAHFLIYDLIFRRFITSQLVPLKVIKERIEYKICEDSNCNSELKTLQNYSEFITDIKLPIQLDYSKFLYLPTTRIIKNSIIKKLQETTGSTNAELVSKIQLTGSFVKSTVNLYTQAELVAEMKRKEIGRPSTYATIISTILKRGYVIESKKTKKLIPTQLGKEVNKYLNQKFSSFVSEERTRNLLQLMDMVEQGKQDYIQILKDIYYEIKSIR

rgy2

Reverse gyrase 2

1215 amino acids

Modifies the topological state of DNA by introducing positive supercoils in an ATP-dependent process. It cleaves transiently a single DNA strand and remains covalently bound to the 5' DNA end through a tyrosine residue. May be involved in rewinding the DNA strands in the regions of the chromosome that have opened up to allow transcription or replication.

In the C-terminal section; belongs to the prokaryotic type I/III topoisomerase family.

134.492 kDa

MPGGVNAVYMGLCYNCGGNIDEDRLEKGLPCARCLPSPPRRATPLTVYRALKKAGTLGAYSWEYLSIREVERFEAYFAAKSGSRLWSAQRSWAKRLVKGDSFAIIAPTGVGKSTLLTVYAAYVAAVKRGRVLYLVPTENLVRQVYAKLDQVEPGIATAYYSRMPAKARESSLEKIASGGARLIVATTGFLSRRFDLLHPQYKFDLAIVDDVDSLLRNSRNVERILLLTGFSEETVEAAHSLVKARLKLYRALHSGASESIVSRLEQEIAQLEARLRLSLSEASPGQLVIASATGRPRGVKHLLFKELLGFEVGGGSDYLRNIVDAYVVDSDPVGRTAEIVSALGDGVIVFVSQRLGKDVARAIAGRLEGMGVSTALALTGARRPVEAFARGEARVLIGMASRYGVIVRGLDLPERSKYAVFLGAPSAKTHLLEALYSPRRMLAFLSIAQEKGVEWAGEAFRRLSRLLEKVIDTSIVSLAARGKLEAQGPAGEAAGIISETAPRLVDWLVAEARLQGGLLRVGGLVVDARGPIPYLVVPDAPTYIQASGRVSRLYRGVMTRGLSIVVDEAPEYVEALGERLKWTTSSRLRPLSEVDMEKLRREIEESRRGKGRRVRVKTTLLVVESPTKARTIAWFWGRPGKRRIGRSVIYEASVSDPETGDVHILQITSTRGHLTDLTTDSVGSKYGVDEDGGGYRAYYSTIKRCLDCGAQHTSSSPFCPRCGSPRQVDSKSVVEILRKLASEVDEIVIATDPDREGEKIAWDVFLAVRPYNPNVRRGRFHEVTPRAVIEALRSGESVEKSLIEAQKVRRIVDRWIGFHLSTHLKLKFSKPWLGAGRVQTPVLGWIVDRYREWQDTRGYLVIFKLSSGGRTSYFTQNRLEVENLKRVEWLEVVDIAGKTEERNPPPPYTTDEYLYDASRKLGLSAGLAMKIAQDLFESGLITYHRTDSTRVSPTGVKLALEYLASRGLEGEAQPRGWGEGGAHEAIRPVRPIDAQDLERAVLSGSIRIPIRLTRLHIRVYDMIFRRFIASQMKPATLDIVEATLQAGETVFNHAGVARVRGGYALVNPPRVEEWLARLSPGDRIDVEDVLVVKSSLKRLYRAGDIVKMMREHGIGRPSTYAKAIEQNRRHGYVIESKKMRYLIPTKTGVSIYDYLSNGFKKLVSVDTTRRLEEALERVEKGVEKPEAVLASVWRMVDEAVSLHAATGDVMGQSEA

rgy2

Reverse gyrase 2

1166 amino acids

Modifies the topological state of DNA by introducing positive supercoils in an ATP-dependent process. It cleaves transiently a single DNA strand and remains covalently bound to the 5' DNA end through a tyrosine residue. May be involved in rewinding the DNA strands in the regions of the chromosome that have opened up to allow transcription or replication.

In the C-terminal section; belongs to the prokaryotic type I/III topoisomerase family.

132.077 kDa

MINVMYKNSCPNCGGDISGDRLLNGLPCEACLPYINGIDDVDHISKVKTLYNILLNNDKIKNYWNLYYNITTFETVFKYFRDKTGYEPWSLQKLWLRRLASNQSFTMSAPTGLGKTTTLMTYSVFIGQDVVYIVPTKSLMEQVCKRLEKLGAQVSCGKIDQKKVSVITISYLNKNADSIVSLKPNFVVIDDADAVIKSGKTTDRLVSLLGIPKDVYESAIQLIRLRNKYYFSNEYTEEVKEKIRELELKIAEFKDKISQLVIASATIRPKGIKQKALRLLTGFEPSSIQLYARNIIDAYTENLDLSIVKELGSGGLILVSKEYGRSKLNEIKKYVEDLGFNAKLAISGRKFLDDFSQGKVDILVGSASYYGVAVRGIDEPKRLKYVIYYGVPKIRAKLFDALSNPFTLLRVGKLIGIDFSKLQNKILILNPSEVQLLKFSIIKGESINYHKLEQLRQELLYYMSLVKDKLKEKVEDTLISDSFVITKQNGNYYIVYPDMITYLQGSGRASRLYNGGLTLGFSIILVDDRHIFEILEKKMQKLFPNTTFTSLSNTNLSEIKIKLEDSRKEEGNRVHFNISTGLLIVESPTKAKTIAKMFSRPSVRIRNKVPVYETIIVDGNQIYVLDIVASKGHIVDLTLEDIGYYGIKVEDDGTIKPYYDLIKKCLDCNKIFSSASDKCPYCGSANLQSAQTTINLLRELALSVDKVFIASDPDTEGEKIAYDLASFLSPYNSNVYRVVYHEITKKAILEALRNPKKINTNLVMSQIVRRIEDRWIGFTLSNLLKTKFNGHNHGAGRVQTPVLGWIVNKTIKYKSAMGHVVYIDIAGYSIKKYFSEKRKVEEYINNLQVARIEKISEEKILLSPLPPFTTDTLLIEANMKYKLPANLVMKIAQDLFEAGLITYHRTDSTHISSVGIEIAKEYLQKQALIKEFVPRSWESSEEGAHEAIRPTRAIDVNELIQEIEENPYKYSIRFSKLHLLIYDLIFKRFIASQMSHAVGTKSRYLIKLGKDDNVDVELLSNAEGGFIKVYPVKVYNLPVGEIQPKVNITKGSSEQLLSYSDVISLMKSKGIGRPSTYAKTIENLMKHGYIVSSKRKSYLIATNRGISVYQFLSSKFYDLVSESTTSRLMTKLDDIALSKLNASTVLLEIFSEISTLVNPLKSEQNV

rgy2

Reverse gyrase 2

1159 amino acids

Modifies the topological state of DNA by introducing positive supercoils in an ATP-dependent process. It cleaves transiently a single DNA strand and remains covalently bound to the 5' DNA end through a tyrosine residue. May be involved in rewinding the DNA strands in the regions of the chromosome that have opened up to allow transcription or replication.

In the C-terminal section; belongs to the prokaryotic type I/III topoisomerase family.

134.557 kDa

MALELIERGCPNCGGVISSDRLEKGLPCSKCLPKPTEEKVCDALEELKTLKYLKPFCDTDKSLERFINFFEKAVGAKPWSLQRVWAKRVFMNQSFAIVAPTGVGKTTFGLVMSLFLKGRVLAIFPTRLLAQQAGDRLSELAQKVGVNKKILIYQSKKNIREQFLNGDWDILLGTNMFLHKNFENLINFKFKLIFIDDIDSFLKRGKNVDYLFKLLGFSGEEIKLALKENKTQRDYDRLARIRKRKRDTVLIVSSATLKPRGKRAYLFRNLLGFDVQKAITTLRNIVDVAEPVKDLEEALEKSVELIKKLGKGGLVYLSVFYGKDKVQEVKEFYRKHGINAVSYLDYKPEELYQILEKGEFDVAVGISHITNPLVRGIDLPHIIRYAVFLDPPKHVFPTELTLSPPLLHGLLLTLLNLFEGDDRLKAIQYVMYLKRYLTLREEQLDNYPRIKERVEEIKNFLENYLKDENFLKKIKESEDISLVPKEGKLYIVVGDANSYIQASGRTSRFIAGGMTKGLSVVYYSDPKAFYSLKKRLALYYMTQEIEFKRLSEVDLNKLIKEIDEDRKRAREILQGKGVAQIKDLFKTTLVIVESPNKARTIAGFFGKPQMRLVEDSVAYEVPLGDRLLVITASLGHVLDLVTDKGFFGVLDDTYPYLPVYDTIKICRETHEQHTEYEYLKKRCKGKIEDKLEIIKGVREVSYEVDEVFIATDPDAEGEKIGYDLYLLSKPFNFNIKRAEFHEVTPKAFREAIQNPREVDLNLVKAQLVRRILDRWVGFTLSHILWDAFGKKWLSAGRVQTPVLGWVIKRYEESKEKKGEILLHVNDFPLKIEIEDLMFAKEIFKDLELADISLSNPQEEEKRPLPPYTTDTVLEDANEKLHLSAHKTMKILQELFEAGYITYHRTDSTRVSDAGKYLVAKPYITKMFGEEYFYPRSWGEGGAHECIRPTRPLEPKDLEFMITAGIAEFEDPENALKVYELIFKRFMASQMRPAKVITEEIILKLPYFEWKERVVTEVKEHGFDLMYPTFKVFPKKEKLEITHKEFREVPKVYPYTQGTLIQEMKRRGLGRPSTYAQIVQTLLERHYVVEEKGFLIPTDLGREVYEYLTKHFPEWTSEELTRKLEEAMDKIERGELDYMEVLKEVHRIKVLLKEEKAFKK