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pup1

Gene
PUP1
Protein
Purine permease 1
Organism
Arabidopsis thaliana
Length
356 amino acids
Function
Proton-coupled purine transporter mediating adenine and trans-zeatin uptake (PubMed:12662305). High affinity transporter for pyridoxine involved in the uptake of vitamin B6 (PubMed:23551747). Also able to transport caffeine and adenosine (PubMed:12662305). May be involved in the uptake of cytokinin, caffeine and nicotine from the xylem sap into shoot tissues (PubMed:12662305).
Similarity
Belongs to the purine permeases (TC 2.A.7.14) family.
Mass
39.28 kDa
Sequence
MKNGLIIINCIILTIGTCGGPLLTRLYFTNGGKRIWFMSFLSTAGFPIILIPLLVSFLSRRRSNRNPNNAENKRKTKLFLMETPLFIASIVIGLLTGLDNYLYSYGLAYLPVSTSSLIIGTQLAFNALFAFLLVKQKFTPFSINAVVLLTVGIGILALHSDGDKPAKESKKEYVVGFLMTVVAALLYAFILPLVELTYKKARQEITFPLVLEIQMVMCLAATFFCVIGMFIVGDFKVIAREAREFKIGGSVFYYALIVITGIIWQGFFLGAIGIVFCASSLASGVLISVLLPVTEVFAVVCFREKFQAEKGVSLLLSLWGFVSYFYGEFKSGKKVVDKPQPPETELPILPVSDYVA

Gene
pup1
Protein
Probable proteasome subunit beta type-2
Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Length
267 amino acids
Function
The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity (Potential).
Similarity
Belongs to the peptidase T1B family.
Mass
29.337 kDa
Sequence
MMGINERKGFDFEYYQRNLLLQEKGFPTPKATSTGTTIVGVIAKDCIVLGADTRATAGPIIADKNCKKLHLISPNIWCAGAGTAADTEFVTSMISSNIELHSLYTNRKPRVVTALTMLKQHLFRYQGHIGAYLVLGGYDCKGPHLFTIAAHGSSDKLPYVALGSGSLAAISVLETKYQPDLERHEAMELVKEAIEAGIFNDLGSGSNCDLVVIDEEKATPYRGYSKPNERATKQSKYTYDRGTTAVLKEDIYKFVTVQDLDEMQVDV

Gene
PUP1
Protein
Proteasome subunit beta type-2
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Length
261 amino acids
Function
The proteasome degrades poly-ubiquitinated proteins in the cytoplasm and in the nucleus. It is essential for the regulated turnover of proteins and for the removal of misfolded proteins. The proteasome is a multicatalytic proteinase complex that is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. It has an ATP-dependent proteolytic activity.
Similarity
Belongs to the peptidase T1B family.
Mass
28.268 kDa
Sequence
MAGLSFDNYQRNNFLAENSHTQPKATSTGTTIVGVKFNNGVVIAADTRSTQGPIVADKNCAKLHRISPKIWCAGAGTAADTEAVTQLIGSNIELHSLYTSREPRVVSALQMLKQHLFKYQGHIGAYLIVAGVDPTGSHLFSIHAHGSTDVGYYLSLGSGSLAAMAVLESHWKQDLTKEEAIKLASDAIQAGIWNDLGSGSNVDVCVMEIGKDAEYLRNYLTPNVREEKQKSYKFPRGTTAVLKESIVNICDIQEEQVDITA

Gene
PUP1
Protein
Probable proteasome subunit beta type-2
Organism
Encephalitozoon cuniculi (strain GB-M1)
Length
227 amino acids
Function
The proteasome degrades poly-ubiquitinated proteins in the cytoplasm and in the nucleus. It is essential for the regulated turnover of proteins and for the removal of misfolded proteins. The proteasome is a multicatalytic proteinase complex that is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. It has an ATP-dependent proteolytic activity (By similarity).
Similarity
Belongs to the peptidase T1B family.
Mass
24.766 kDa
Sequence
MITKTGTTIVGMKYKTGVILAADTRSTQGPVVSDKNCVKIHQITDKIMCCGAGTAADASRVARMASRELRLFQNKYLRLPLVSHFRKVCTQHLHKYGGGIGAALIVGGIDSEGCHLYEIHPHGSENSALFVSLGSGSLGAIATLESRYRAMDKDEAIDLACDAVKAGILNDLYSGSNIDVCVIDYSGVEFLRNYRRIGVSENTDTLVYPLDSVRIKREEVFDIVEEY

Gene
PUP1
Protein
PDR1 up-regulated protein 1
Organism
Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)
Length
211 amino acids
Function
Mitochondrial protein that contributes to the enhanced virulence of C.glabrata strains that acquired azole resistance.
Similarity
Belongs to the PUP1 family.
Mass
24.379 kDa
Sequence
MSDSREIKKPWWFKKAKEWADEFYTRDQKLEDSDRRDLSKKYATISKASVVGAATGLSAGLGGPYAYRYYTTGALKGVKLPRTILLGVVSMVIMRNVAAKIAWDKELKKLDPSGELKQNYKSAHKTVDDVSLSDNSTSVQKKYGMMKFLKYRTAPRWAMYFEGTYQHPDRKFPNPDQMVQDLKGSRRAFPPFFSKADKFWHQIDRKDNDHT

Gene
pup1
Protein
Prokaryotic ubiquitin-like protein Pup 1
Organism
Rhodococcus erythropolis
Length
64 amino acids
Function
Protein modifier that is covalently attached to lysine residues of substrate proteins, thereby targeting them for proteasomal degradation. The tagging system is termed pupylation.
Similarity
Belongs to the prokaryotic ubiquitin-like protein family.
Mass
6.956 kDa
Sequence
MAQEQTKRTGGGDEDDTPGGDGAAGQERREKLAEDTDDLLDEIDDVLEENAEDFVRAYVQKGGQ

Gene
pup1
Protein
Prokaryotic ubiquitin-like protein Pup 1
Organism
Saccharopolyspora erythraea (strain ATCC 11635 / DSM 40517 / JCM 4748 / NBRC 13426 / NCIMB 8594 / NRRL 2338)
Length
63 amino acids
Function
Protein modifier that is covalently attached to lysine residues of substrate proteins, thereby targeting them for proteasomal degradation. The tagging system is termed pupylation.
Similarity
Belongs to the prokaryotic ubiquitin-like protein family.
Mass
6.917 kDa
Sequence
MSQEKVQRHGGGDGEEESGPEAAGQERREKLGEDVDAILDEIDDVLEENAEDFVRAYVQKGGQ