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ptmA

Gene
ptmA
Protein
Penitrem biosynthesis cluster 1 protein A
Organism
Penicillium simplicissimum
Length
368 amino acids
Function
Part of the gene cluster that mediates the biosynthesis of the indole diterpenes penitrems (PubMed:25831977). The geranylgeranyl diphosphate (GGPP) synthase ptmG catalyzes the first step in penitrem biosynthesis via conversion of farnesyl pyrophosphate and isopentyl pyrophosphate into geranylgeranyl pyrophosphate (GGPP) (PubMed:25831977). Condensation of indole-3-glycerol phosphate with GGPP by the prenyl transferase ptmC then forms 3-geranylgeranylindole (3-GGI) (PubMed:25831977). Epoxidation by the FAD-dependent monooxygenase ptmM leads to a epoxidized-GGI that is substrate of the terpene cyclase ptmB for cyclization to yield paspaline (PubMed:25831977). Paspaline is subsequently converted to 13-desoxypaxilline by the cytochrome P450 monooxygenase ptmP, the latter being then converted to paxilline by the cytochrome P450 monooxygenase ptmQ (PubMed:25831977). Paxilline is converted to beta-paxitriol via C-10 ketoreduction by the short-chain dehydrogenase ptmH which can be monoprenylated at the C-20 by the indole diterpene prenyltransferase ptmD (PubMed:25831977). A two-step elimination (acetylation and elimination) process performed by the O-acetyltransferase ptmV and ptmI leads to the production of the prenylated form of penijanthine (PubMed:25831977). The FAD-linked oxidoreductase ptmO then converts the prenylated form of penijanthine into PC-M5 which is in turn transformed into PC-M4 by the aromatic dimethylallyltransferase ptmE (PubMed:25831977). Five sequential oxidative transformations performed by the cytochrome P450 monooxygenases ptmK, ptmU, ptmL, ptmN and ptmJ yield the various penitrem compounds. PtmK, ptmU and ptmM are involved in the formation of the key bicyclic ring of penitrem C via the formation of the intermediates secopenitrem D and penitrem D. PtmL catalyzes the epoxidation of penitrem D and C to yield penitrem B and F, respectively. PtmJ catalyzes the last benzylic hydroxylation to convert penitrem B to prenitrem E and penitrem F to penitrem A (PubMed:25831977).
Similarity
Belongs to the paxA family.
Mass
40.64 kDa
Sequence
MSRVIRSILIILGSVALYTKYYLSFQNGFIDLLSTMGSQGSLAGLQSGLRSHYTGLDPLDRFLKACNVFFWPIFHGTSPALSLYAIAFAGSMIPMWLILLMHTCVNSSIVEIVMINALAGLLVQGIGPGVIMCVLLAMRNTSMKEFAVTGIPAVSILGPNDLPLSLVVCYILPLALSSLPAPASISVPSKQLFIAIWQGWPLYIALAVGIAHSLRNHYRRNRPQQLFRHAYAFALACSIISHVGLLSISFLSVSPQSPFLSLHSADLHPRSLLIPRLPWQEVKITSLESGVLRFLHWDYSISSTGTLLWCYDVYWKDRMRGRGWIAFFSLSSRLATMSLAFGPCSVALALYWAALSNNLMKSENARKR

Gene
ptmA
Protein
Post-translational flagellin modification protein A
Organism
Campylobacter coli
Length
256 amino acids
Function
Required for biosynthesis of LAH modification in the post-translational modification of Campylobacter coli flagellin.
Similarity
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Mass
28.489 kDa
Sequence
MLENKIIFVAGACGRIGKALCKKILQNKGIAILADINENHLSILKTELENEFKKELLSLRLDITSKESLNCAIDQAFEKYSKIDGFVNSSYPVGKDWGKIAYYEASYEQICESLNLHLGGFILASQEFVKFFKKQSYGNIINLSSIMGVFAPKFENYENTTMQSSLEYSVIKAGINHLGAWLAKELFNTNIRVNTLASGGILDNQANIFLEKYRKCCASKGMLDAEDICGTLVFLLSDESKFVTGQTLVVDDGWGL

Gene
Ptma
Protein
Prothymosin alpha
Organism
Rattus norvegicus
Length
112 amino acids
Function
Prothymosin alpha may mediate immune function by conferring resistance to certain opportunistic infections.
Similarity
Belongs to the pro/parathymosin family.
Mass
12.382 kDa
Sequence
MSDAAVDTSSEITTKDLKEKKEVVEEAENGRDAPANGNAQNEENGEQEADNEVDEEEEEGGEEEEEEEEGDGEEEDGDEDEEAEAPTGKRVAEDDEDDDVETKKQKKTDEDD

Gene
PTMA
Protein
Prothymosin alpha
Organism
Homo sapiens
Length
111 amino acids
Function
Prothymosin alpha may mediate immune function by conferring resistance to certain opportunistic infections.
Similarity
Belongs to the pro/parathymosin family.
Mass
12.203 kDa
Sequence
MSDAAVDTSSEITTKDLKEKKEVVEEAENGRDAPANGNAENEENGEQEADNEVDEEEEEGGEEEEEEEEGDGEEEDGDEDEEAESATGKRAAEDDEDDDVDTKKQKTDEDD

Gene
Ptma
Protein
Prothymosin alpha
Organism
Mus musculus
Length
111 amino acids
Function
Prothymosin alpha may mediate immune function by conferring resistance to certain opportunistic infections.
Similarity
Belongs to the pro/parathymosin family.
Mass
12.254 kDa
Sequence
MSDAAVDTSSEITTKDLKEKKEVVEEAENGRDAPANGNAQNEENGEQEADNEVDEEEEEGGEEEEEEEEGDGEEEDGDEDEEAEAPTGKRVAEDDEDDDVDTKKQKTEEDD

Gene
PTMA
Protein
Prothymosin alpha
Organism
Pongo abelii
Length
110 amino acids
Function
Prothymosin alpha may mediate immune function by conferring resistance to certain opportunistic infections.
Similarity
Belongs to the pro/parathymosin family.
Mass
12.102 kDa
Sequence
MSDAAVDTSSEITTKDLKEKKEVVEEAENGRDVPANGNANEENGEQEADNEVDEEEEEGGEEEEEEEEGDGEEEDGDEDEEAESATGKRAAEDDEDDDVDTKKQKTDEDD

Gene
PTMA
Protein
Prothymosin alpha
Organism
Bos taurus
Length
110 amino acids
Function
Prothymosin alpha may mediate immune function by conferring resistance to certain opportunistic infections.
Similarity
Belongs to the pro/parathymosin family.
Mass
12.072 kDa
Sequence
MSDAAVDTSSEITTKDLKEKKEVVEEAENGREAPANGNANEENGEQEADNEVDEEEEEGGEEEEEEEEGDGEEEDGDEDEEAEAATGKRAAEDDEDDDVDTKKQKTDEDD