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pth4

Gene
pth4
Protein
Parathyroid hormone 4
Organism
Danio rerio
Length
121 amino acids
Function
Neuroendocrine peptide which is produced by a subset of neurons in the hypothalamus. Activates the G-protein coupled receptors pth1ra, pth1rb and pth2r with similar affinity. Receptor binding stimulates intracellular cAMP production. Plays a role in bone mineralization by regulating expression of factors involved in phosphate homeostasis. Important for embryonic bone development.
Similarity
Belongs to the parathyroid hormone family.
Mass
13.799 kDa
Sequence
MLKMQRSQQRVALMMLMVVAAVHCQESESRRAVTEHQLMHDRGRSIQSLKRLIWLSSAIEGLHTAQARTLEPDSRWRSRGAQLYSQPGREESSGGQKRALETLLSDLYRAHLTFGLGEPEK