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pth2

Gene
pth2
Protein
Peptidyl-tRNA hydrolase 2
Organism
Corynebacterium jeikeium (strain K411)
Length
240 amino acids
Function
The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.
Similarity
Belongs to the PTH family.
Mass
26.242 kDa
Sequence
MAVSFLQSLFSVFRKKSSPQEPATTTAGGPAKRTKLTVGELQEFAPEWIVIGLGNPGAKYADTRHNIGYWPIDRLVERYEAQWLPVEGQKAHAALITVEETPVLLLRSTTYMNNSGEAVGPLASALSLPAERIIVCHDELDIAAGQVRIKDKGGEGGHNGLRSMTAELGTQHYVRVRMGIGRPPKGTSVIDFVLSPFEEADIDAENGWMENTLRDSVDSVTLIVNNGTDIARNDIHTRKH

Gene
pth2
Protein
Probable peptidyl-tRNA hydrolase 2
Organism
Dictyostelium discoideum
Length
210 amino acids
Function
The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.
Similarity
Belongs to the PTH2 family.
Mass
23.517 kDa
Sequence
MQLNKDILLVSIISLFSGVLLGYFQAKCFKRSTITKNKEEVEQIKEIENNNQKEKEKEEKEGDDDDDDDDESESIDGDYDENDDYEIEYDEEIGDCKQVLVIRTDLGMTKGKIIAQCCHASLGARQKALKDSKKVLRQWENFGCAKITLKANSKEELVDLRNKAKELGVVSYLVLDSGHTQIPSGSATVLAVGPAPKEAVDAVTKHLKLY

Gene
PTH2
Protein
Peptidyl-tRNA hydrolase 2
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Length
208 amino acids
Function
The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.
Similarity
Belongs to the PTH2 family.
Mass
22.435 kDa
Sequence
MEKMTVSSNYTIALWATFTAISFAVGYQLGTSNASSTKKSSATLLRSKEMKEGKLHNDTDEEESESEDESDEDEDIESTSLNDIPGEVRMALVIRQDLGMTKGKIAAQCCHAALSCFRHIATNPARASYNPIMTQRWLNAGQAKITLKCPDKFTMDELYAKAISLGVNAAVIHDAGRTQIAAGSATVLGLGPAPKAVLDQITGDLKLY

Gene
pth2
Protein
Peptidyl-tRNA hydrolase 2
Organism
Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025)
Length
204 amino acids
Function
The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.
Similarity
Belongs to the PTH family.
Mass
21.695 kDa
Sequence
MTSVSFLSKIQALFAPKPELPAAKWLVVGLGNPGAKYESTRHNVGYMCQDMLIDAHQQQPLTPATGYKALTTQLAPGVLAVRSTTFMNHSGQGVAPIAAALGIPAERIIVIHDELDLPAGKVRLKKGGNENGHNGLKSLTEELGTRDYLRVRIGISRPPAGMAVPDYVLEPVDHDQPGIELAAEAVDLLLAQGLSAAQNAIHSR

Gene
pth2
Protein
Tuberoinfundibular peptide of 39 residues
Organism
Danio rerio
Length
157 amino acids
Function
Plays a role as a potent and selective agonist of pth2r resulting in adenyl cyclase activation and intracellular calcium level elevation.
Similarity
Belongs to the parathyroid hormone family.
Mass
17.75 kDa
Sequence
MALSLPPRPALLFLVLMSVTLMASAFPQPQLRPLQSNLPAIGQEDSKGEQWEVVYPSISLRDWSIQMLTAPDFGAAKTGREQLVADDWLPLSQSQMEEELVKGWTGDWPSRVGHQQKRNIVVADDAAFREKSKLLTAMERQKWLNSYMQKLLVVNSK

Gene
PTH2
Protein
Tuberoinfundibular peptide of 39 residues
Organism
Bos taurus
Length
100 amino acids
Function
Plays a role as a potent and selective agonist of PTH2R resulting in adenyl cyclase activation and intracellular calcium levels elevation. Induces protein kinase C beta activation, recruitment of beta-arrestin and PTH2R internalization. May inhibit cell proliferation via its action of PTH2R activation. Neuropeptide which may also have a role in spermatogenesis. May activate nociceptors and nociceptive circuits.
Similarity
Belongs to the parathyroid hormone family.
Mass
11.202 kDa
Sequence
METRQVSRSPRVRLLLLLLLLLVVPWGVRTASGVALPPVGVLSLRPPGRAWADPATPRPRRSLALADDAAFRERARLLAALERRHWLNSYMHKLLVLDAP

Gene
PTH2
Protein
Tuberoinfundibular peptide of 39 residues
Organism
Homo sapiens
Length
100 amino acids
Function
Plays a role as a potent and selective agonist of PTH2R resulting in adenyl cyclase activation and intracellular calcium levels elevation. Induces protein kinase C beta activation, recruitment of beta-arrestin and PTH2R internalization. May inhibit cell proliferation via its action on PTH2R activation. Neuropeptide which may also have a role in spermatogenesis. May activate nociceptors and nociceptive circuits.
Similarity
Belongs to the parathyroid hormone family.
Mass
11.202 kDa
Sequence
METRQVSRSPRVRLLLLLLLLLVVPWGVRTASGVALPPVGVLSLRPPGRAWADPATPRPRRSLALADDAAFRERARLLAALERRHWLNSYMHKLLVLDAP

Gene
Pth2
Protein
Tuberoinfundibular peptide of 39 residues
Organism
Mus musculus
Length
100 amino acids
Function
Plays a role as a potent and selective agonist of PTH2R resulting in adenyl cyclase activation and intracellular calcium levels elevation. Induces protein kinase C beta activation, recruitment of beta-arrestin and PTH2R internalization. May inhibit cell proliferation via its action of PTH2R activation. Neuropeptide which may also have a role in spermatogenesis. May activate nociceptors and nociceptive circuits.
Similarity
Belongs to the parathyroid hormone family.
Mass
11.022 kDa
Sequence
METCQMSRSPRERLLLLLLLLLLVPWGTGPASGVALPLAGVFSLRAPGRAWAGLGSPLSRRSLALADDAAFRERARLLAALERRRWLDSYMQKLLLLDAP

Gene
Pth2
Protein
Tuberoinfundibular peptide of 39 residues
Organism
Rattus norvegicus
Length
100 amino acids
Function
Plays a role as a potent and selective agonist of PTH2R resulting in adenyl cyclase activation and intracellular calcium levels elevation. Induces protein kinase C beta activation, recruitment of beta-arrestin and PTH2R internalization. May inhibit cell proliferation via its action of PTH2R activation. Neuropeptide which may also have a role in spermatogenesis. May activate nociceptors and nociceptive circuits.
Similarity
Belongs to the parathyroid hormone family.
Mass
11.022 kDa
Sequence
METCQMSRSPRERLLLLLLLLLLVPWGTGPASGVALPLAGVFSLRAPGRAWAGLGSPLSRRSLALADDAAFRERARLLAALERRRWLDSYMQKLLLLDAP