Pomt2

Protein O-mannosyl-transferase 2

820 amino acids

Transfers mannosyl residues to the hydroxyl group of serine or threonine residues. Coexpression of both POMT1 and POMT2 is necessary for enzyme activity, expression of either POMT1 or POMT2 alone is insufficient. Essentially dedicated to O-mannosylation of alpha-DAG1 and few other proteins but not of cadherins and protocaherins.

Belongs to the glycosyltransferase 39 family.

92.386 kDa

MLYASGRLLAARAATTLSAPPRARGPALRGKRRELQIPWHLETPSYDPLTGQRTRPGVPPARRVILRKGRMPPAIGGGLAGSELRPRRGRCVPQAARAVSRDVVPQAAARKLKRPAWSSRRFQAAGWWATLAVVTLLSFATRFHRLDQPAHICWDETHFGKMGSYYINRTFFFDVHPPLGKMLIGLAGYLSGYDGTFLFQKPGDRYEHHSYMGMRGFCAFLGSWLIPFAYLTVLDLSKSFPAALLTAALLTFDTGCLTLSQYILLDPILMFFIMAAMLSMVKYNSCANRPFSAPWWFWLSLTGISLAGALGVKFVGLFIIVQVGLNTISDLWHLFGDLSLSLVTVGKHLTARILCLIVLPLVLYVTIFAVHVMVLNKSGPGDGFFSSAFQARLSGNSLHNASIPEHLAYGSVITVKNLRMAIGYLHSHRHLYPEGIGARQQQVTTYLHKDYNNLWIIKKYNANTDPLDPSFPVEFVRHGDIIRLEHKETTRNLHSHYHEAPLTRKHYQVTGYGINGTGDSNDFWRIEVVNRKFGNRIKVLRSRIRLIHLVTGCVLGSSGKILPKWGWEQLEVTCTPYLKETTNSIWNIEEHINPKLPNISLDVLQPSFPEILLESHMVMIRGNNGLKPKDNEFTSKPWHWPINYQGLRFSGANDTDFRVYLLGNPVVWWLNLVSIVLYLLSGSTIAVAMQRGIQLPAELQGLTKVLLRGGGQLLLGWMLHYFPFFLMGRILYFHHYFPAMLFSSMLTGILWDTLLRLCAWGLAPSPLGRRIHAVGILSLLLTTAYSFYLFHPLAYGMVGPLAQEPESPMAGLRWLESWDF

pomt2

Protein O-mannosyl-transferase 2

756 amino acids

Transfers mannosyl residues to the hydroxyl group of serine or threonine residues. Coexpression of both POMT1 and POMT2 is necessary for enzyme activity, expression of either POMT1 or POMT2 alone is insufficient.

Belongs to the glycosyltransferase 39 family.

85.711 kDa

MDVRPKENFSQRQDTSAVRHRKTCKVNERAEIPSQPHNGTINGVNKRITKREGGEHISSPSRDAHVPVFILALVIVLSVSTRFYKITEPPHVCWDETHFGKMGSYYINRTFFFDVHPPLGKMLIGLAGYLTGYDGTFPFIKPGDKYEHHNYWGMRAFCAALGSCLPPFAFLVVLELSQSSTAALIAASLLIFDTGCITLSQYILLDPILMFFIMGSVLCMVKFNTQRLGPFSFSWWFWLLLTGLCLSGSLGVKFVGLFVILLVGINTALDLWRLLGDLSLSLVDFGKHLLARVFGLIMLPLFLYTTIFAIHFIVLNRSGPGDGFFSSAFQSRLIGNNLHNASMPEYLAYGSVITVKNLRIAGGYLHSHWHLYPEGVGAHQQQVTAYLHKDYNNLWLVKRLDNSDDLTGSPELVRHGDIIRLEHKETTRNLHSHFHEAPLTKKHLQVTGYGINGSGDVNDLWQVEVCGGRKGDPVKVLRSKVRFLHRATGCVLCSSGKTLPKWGWEQVEVTCSPYVKETPNSQWNIEDHINPKLPNISLAVLKPTFLEILWESHIVMIRGNSGLKPKDNEMNSKPWHWPINYQGLRFSGVNETEYRVYLLGNPVIWWLNLLSLALFVILLTVASLAVQRRVKMEGMMKVHCHTLMEGGGMLFLGWLLHYLPFYIMGRILYYHHYFPAMMFSSMLTGITLDILLQNLQLLFSSSLSHYLMRGGQSVLLLGFIYSFYLFHPLSYGMRGPLAHDSASSMAGLRWMESWEF

POMT2

Protein O-mannosyl-transferase 2

750 amino acids

Transfers mannosyl residues to the hydroxyl group of serine or threonine residues. Coexpression of both POMT1 and POMT2 is necessary for enzyme activity, expression of either POMT1 or POMT2 alone is insufficient (PubMed:14699049, PubMed:28512129). Essentially dedicated to O-mannosylation of alpha-DAG1 and few other proteins but not of cadherins and protocaherins (PubMed:28512129).

Belongs to the glycosyltransferase 39 family.

84.214 kDa

MPPATGGGLAESELRPRRGRCGPQAARAAGRDVAAEAVARSPKRPAWGSRRFEAVGWWALLALVTLLSFATRFHRLDEPPHICWDETHFGKMGSYYINRTFFFDVHPPLGKMLIGLAGYLSGYDGTFLFQKPGDKYEHHSYMGMRGFCAFLGSWLVPFAYLTVLDLSKSLSAALLTAALLTFDTGCLTLSQYILLDPILMFFIMAAMLSMVKYNSCADRPFSAPWWFWLSLTGVSLAGALGVKFVGLFIILQVGLNTIADLWYLFGDLSLSLVTVGKHLTARVLCLIVLPLALYTATFAVHFMVLSKSGPGDGFFSSAFQARLSGNNLHNASIPEHLAYGSVITVKNLRMAIGYLHSHRHLYPEGIGARQQQVTTYLHKDYNNLWIIKKHNTNSDPLDPSFPVEFVRHGDIIRLEHKETSRNLHSHYHEAPMTRKHYQVTGYGINGTGDSNDFWRIEVVNRKFGNRIKVLRSRIRFIHLVTGCVLGSSGKVLPKWGWEQLEVTCTPYLKETLNSIWNVEDHINPKLPNISLDVLQPSFPEILLESHMVMIRGNSGLKPKDNEFTSKPWHWPINYQGLRFSGVNDTDFRVYLLGNPVVWWLNLLSIALYLLSGSIIAVAMQRGARLPAEVAGLSQVLLRGGGQVLLGWTLHYFPFFLMGRVLYFHHYFPAMLFSSMLTGILWDTLLRLCAWGLASWPLARGIHVAGILSLLLGTAYSFYLFHPLAYGMVGPLAQDPQSPMAGLRWLDSWDF