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polq-1

Gene
polq-1
Protein
DNA polymerase theta
Organism
Caenorhabditis elegans
Length
1661 amino acids
Function
DNA polymerase that promotes microhomology-mediated end-joining (MMEJ), an alternative non-homologous end-joining (NHEJ) machinery triggered in response to double-strand breaks in DNA. MMEJ is an error-prone repair pathway that produces deletions of sequences from the strand being repaired and promotes genomic rearrangements, such as telomere fusions (PubMed:24614976). Required to prevent extensive loss of sequences near G-quadruplex (G4) DNA sites, which are prone to cause genome alterations, by generating deletions (PubMed:24496117).
Similarity
Belongs to the DNA polymerase type-A family.
Mass
188.679 kDa
Sequence
MDEASCRFPEWVSSKIIDYYAEQNIKALFDWQIDVLNEARQFEDQHLIFSAPTSAGKSIVAELLSWKVASTGRKVLFVLPYISVAREKLHQIQRCWRRDDISVCGFIGPQASNPNEWLGAVCTIEKAASLTNRALSEDWFEEIGMIVVDEMHMVFDSSRGAHIEHMLSKVLLWNQSALEKVRIIGMSATIPELYRIGKWLDGAKVFEARFRPIVLQNHIVIGSELRKSGDNKVLREFSEDPLILLTEESFRRNSQTLVMISSKLDAEKTALNIASRFHEINKTDSSLLEILKERANGLLFIKHGLERNGCKDRNVMSTLAWGVAYHHAGLTMEERECIELGFREKNIVILVATSTLASGVNLPAERVLIKAQPRGPSALTSLNYRQMVGRAGRTGHATRGETYLLIKKCDRDAVLKIIETPIDQGVLTRKRDAERTNLSRFILEGICTGLTTTRSQIHDLCKLLLFNSENLQLSDIAIEMLLRNSFISQDENDDQLSPTQLGRAAIASSLPPEASLAIFEDLNSASRAIALDTELHMLYLVYFYKNSRAQIIQKIFKIYSIFILKKFKNLEPKFKKKISENITVHITNSIRKKQHFWHVTPINVSVWQECDWHHLFSIFSKLPSDHKRIAKLVGVSEKFILDQLQGRRNDKLLQIHIRFFSALALFDLISEMSIYEVSHKYRIPRGCLQTLQSQSATYAAMIVAFCLRLGWTYLKALLDGFATRLLFGVRSELSELVAIEGIDGQRARILHERGVTCLSHLSACDSSKLAHFLTLAVPYSSSNSNDGLGEWLFGEPRMRVDVAARTLKERARKVLIRRVQELGISVELPKFEENEENIQESCDSGLPDSCEGMEDELEEKENIVKMEEMTKSVTEMSLTDNTISFKSEDDLFKKEIKVEEDEVFIKKEIDEDEEEIVEETVIECLETSLLKLKASTDEVFLRRLSQTFSPIGRSRSILNNSLLEDSFDRPVPRSSIPILNFITPKRESPTPYFEDSFDRPIPGSLPISSSRRKSVLTNIANLDSSRRESINSNASDNNSFDVFVTPPTKSAKEEKRRIAVKHPRVGNIIYSPLTSSPVIKHPKLEINHFYLKDVCHDHNAWNLWTKSSTSTSSCSIRVSDDYTGIAIRTDAGNTFIPLLETFGGEPSPASKYFESFSKCIIPLNTRLEFLKTLAVTVEMYISSMEDAFLIFEKFGIKIFRLKVVRIAAYLNNVIDVEQEENSNFLPILMDRYSILDPEIRKTCSSSLHKAAVEVYSLKPIFEKMCCSGASLQLEMESCQTVLNIFYSGIVFDQALCNSFIYKIRKQIENLEENIWRLAYGKFNIHSSNEVANVLFYRLGLIYPETSGCKPKLRHLPTNKLILEQMNTQHPIVGKILEYRQIQHTLTQCLMPLAKFIGRIHCWFEMCTSTGRILTSVPNLQNVPKRISSDGMSARQLFIANSENLLIGADYKQLELRVLAHLSNDSNLVNLITSDRDLFEELSIQWNFPRDAVKQLCYGLIYGMGAKSLSELTRMSIEDAEKMLKAFFAMFPGVRSYINETKEKVCKEEPISTIIGRRTIIKASGIGEERARIERVAVNYTIQGSASEIFKTAIVDIESKIKEFGAQIVLTIHDEVLVECPEIHVAAASESIENCMQNALSHLLRVPMRVSMKTGRSWADLK