pole

Gene

pole

Protein

DNA polymerase epsilon catalytic subunit A

Organism

Dictyostelium discoideum

Length

2380 amino acids

Function

DNA polymerase II participates in chromosomal DNA replication.

Similarity

Belongs to the DNA polymerase type-B family.

Mass

275.442 kDa

Sequence

MSQKWNENKKNKDEKDENDKYVGFKNYEKEGWLLNMQPGSSKDGLDIEKASLELFFIQDDATSFRVWIPYNPYFYIYVKEGHQSEVESYLKSTYEKDIAGIDIMDKEDLDLENHLSGLKRKYLKIRFHNVSTLLSVRNDLFPIIKRNKQKSNTSEAYEDESLNKILNSYYNKGNNNNNNHQNYNNNNNQNNNNFNKELNKDDNNNNNSKLNKQATEYILDIREYDVPYYVRAAIDLNIRVGLWYTVIKNGRLTTVNELTTRVDRPDPKVLAYDIETTKLPLKFPDSSIDSIMMISYMLDKQGYLIVNREIVSEDIKDFEYTPKPEYYGPFTVFNEPDEKSVLERFFSEIKREKPHIFVSYNGDMFDWPFVESRAEYHGLSMFHQIGFRNDNGEYRSKINPHMDAFCWVKRDSYLPHGSHGLKAVTREKLRYDPLELDPELMLKSAQEDPETLANYSVSDAVATYYLYMNYVHPFIFSLCTIIPMNPDDVLRKGSGTLCEALLMTQAFKADVIFPNKHKDDINSMYKGHLLESETYVGGHVECLESGVFRSDIPTNFSLDPASIEKHMGNIDQVLKFALKEGGIPLDTVSNYQEVKEDVLKKFTLLKENPKQQSHPLIYHLDVSAMYPNIILTNKLQPTAVVNDEVCATCVYNKPESQCQRTLDWQWRGDYSPSNQSEYRLILQQLESEKFGDGDERKSFLSLSEEKRNELLRKRLKEYSRKVYRKTHQITQEIRSDTICMRENSFYVDTVRLFRDRRYVFKNHHRDWKIKYDQAMQESGGTNSVAVVAAQGMVVLYESLQLAHKCILNSFYGYVMRKGARWYSMQMAGIVTHTGSNIIKEAREVVEQMGRPLEIDTDGIWCILPSHFPENYTLKSASTGKKVTFSYICEMLNEKVAKSFTNHQYQDYNAETNTYTIRDECSILFECDGPYRCMLIPTSKEKDVKLKKRYAVFNREGRICELKGFEIKRRGELKLIKLFQSEVFKEFLGGDSLEGCYQSVGAVANRWLDILDSHAENYEEKDLIELITESSNMSRKLEEYGTQKSSAISTAKKLAEFLGDDMIKDKGLSCQYIISNKPAGSPITERALPVAIFDADFETRCHYLRRWTKSPSGDLDIRELIDWDYYRQRLSGVIQKIITIPAALQNVTNPVPRVIHPDWILKEIRRNEDGRQQTSITSFFEKTEDNDQDNDNDNDNDNDNDNDNSKPQQTDDIENMFSSRFKDLPAFNPKVTKFKRSKQSSSDVSSLLIKKSKSSIETFTNEQEKQIMETKTPSIDKDFQGWLSISKKKWKIQRLLKKRRQRLGGSLFDSDSFRIGSKLTNRESSSSSFFKSQSDIIKKGYWNIISIEPIYGGEPGIYQMWSLIEDQLIPIKVDIGRVFYLNSIDTDPYEDAQKNTNVIPPRGKQRFNVFSVTMSESQFLEQSKELNTLFTNPMIEGVYETKVPLDIKAIIQCGCVATLSRVSPFFTKIVNSNTRFSLEDIASKPDKQFHYLAEHNFNQLFLYHNSRDGKDGYFVLFNMNTQQCSVIFSNPYMAANKIDARVLNSIKEKLPEITFTMDQKSSMSLAKKEIGSLIMEYQRKGLPTIILLQVPNAIGILEQIPILREFPRVPVPYHDNDSMYSPFNWDVHSLKPLPLRLMDAPKLWVYYANMSRYANIPIGNIPTDNASFMCDILYARSLVEQKHLLWMSDSNFPDLGGSEEDDAKFYEELNNVEINNSDCYNQVCFELDIENLATNTILESIHLAEIEGILGNELGDESNVAMFDDIKNTSNNSNTKNGANQNTTNDTTSSFDKLSITNKFRSAINHQISGCEKEFNILRNLVSKWKLDLVSGSNSKRNEISSRYSNYLLLHFYRWISSTNSKLYDPILYRTLHQLMKKVFIQLIFEFKKLGSKIVYANFNKIIICSQKDSIEDARSYCNYILAVIKKKELFSWINFKQTNYYHNLLWLNNSNYSGILYFNPLINKNQQQQQQQQDNADDDDDDDVSENEEEQQQNKNKKLKKIKNGKIITNWNIAEFLPPQIQTSFIIIISDYIYKLHTERDELNRIQKEQQQRYLLKQKISTTSSSSNNDSTAATTTTTKDTINEPTKPDLRKSSTWNEEEDEDISIPPSSSSSTTTTTSKTKKATSKFDLLIDVNRIFTLLDHFQVNQSSLEFPQLPGGYLKLNNPPLEFIKFVCHVLSIDKSISSRVSRLRMKLMTSMKVREFSDEAKFKDPCVSFTLPDVICSSCHSCRDIDLLRNTNTTSISSRLSSQQKSNNNDSDDSDDDNEENEGDDDNIIRVPELSCIQCKGHYSKNTIESQLVEIIQRRSLSYQLQDLRCSKCNDVKSDNLGDICPQCSGQWECTQSNNLFSKDLIIFKSIAEYHNFEWLGETVDSLSKFI

Gene

POLE

Protein

DNA polymerase epsilon catalytic subunit A

Organism

Homo sapiens

Length

2286 amino acids

Function

Participates in DNA repair and in chromosomal DNA replication.

Similarity

Belongs to the DNA polymerase type-B family.

Mass

261.518 kDa

Sequence

MSLRSGGRRRADPGADGEASRDDGATSSVSALKRLERSQWTDKMDLRFGFERLKEPGEKTGWLINMHPTEILDEDKRLGSAVDYYFIQDDGSRFKVALPYKPYFYIATRKGCEREVSSFLSKKFQGKIAKVETVPKEDLDLPNHLVGLKRNYIRLSFHTVEDLVKVRKEISPAVKKNREQDHASDAYTALLSSVLQRGGVITDEEETSKKIADQLDNIVDMREYDVPYHIRLSIDLKIHVAHWYNVRYRGNAFPVEITRRDDLVERPDPVVLAFDIETTKLPLKFPDAETDQIMMISYMIDGQGYLITNREIVSEDIEDFEFTPKPEYEGPFCVFNEPDEAHLIQRWFEHVQETKPTIMVTYNGDFFDWPFVEARAAVHGLSMQQEIGFQKDSQGEYKAPQCIHMDCLRWVKRDSYLPVGSHNLKAAAKAKLGYDPVELDPEDMCRMATEQPQTLATYSVSDAVATYYLYMKYVHPFIFALCTIIPMEPDEVLRKGSGTLCEALLMVQAFHANIIFPNKQEQEFNKLTDDGHVLDSETYVGGHVEALESGVFRSDIPCRFRMNPAAFDFLLQRVEKTLRHALEEEEKVPVEQVTNFEEVCDEIKSKLASLKDVPSRIECPLIYHLDVGAMYPNIILTNRLQPSAMVDEATCAACDFNKPGANCQRKMAWQWRGEFMPASRSEYHRIQHQLESEKFPPLFPEGPARAFHELSREEQAKYEKRRLADYCRKAYKKIHITKVEERLTTICQRENSFYVDTVRAFRDRRYEFKGLHKVWKKKLSAAVEVGDAAEVKRCKNMEVLYDSLQLAHKCILNSFYGYVMRKGARWYSMEMAGIVCFTGANIITQARELIEQIGRPLELDTDGIWCVLPNSFPENFVFKTTNVKKPKVTISYPGAMLNIMVKEGFTNDQYQELAEPSSLTYVTRSENSIFFEVDGPYLAMILPASKEEGKKLKKRYAVFNEDGSLAELKGFEVKRRGELQLIKIFQSSVFEAFLKGSTLEEVYGSVAKVADYWLDVLYSKAANMPDSELFELISENRSMSRKLEDYGEQKSTSISTAKRLAEFLGDQMVKDAGLSCRYIISRKPEGSPVTERAIPLAIFQAEPTVRKHFLRKWLKSSSLQDFDIRAILDWDYYIERLGSAIQKIITIPAALQQVKNPVPRVKHPDWLHKKLLEKNDVYKQKKISELFTLEGRRQVTMAEASEDSPRPSAPDMEDFGLVKLPHPAAPVTVKRKRVLWESQEESQDLTPTVPWQEILGQPPALGTSQEEWLVWLRFHKKKWQLQARQRLARRKRQRLESAEGVLRPGAIRDGPATGLGSFLRRTARSILDLPWQIVQISETSQAGLFRLWALVGSDLHCIRLSIPRVFYVNQRVAKAEEGASYRKVNRVLPRSNMVYNLYEYSVPEDMYQEHINEINAELSAPDIEGVYETQVPLLFRALVHLGCVCVVNKQLVRHLSGWEAETFALEHLEMRSLAQFSYLEPGSIRHIYLYHHAQAHKALFGIFIPSQRRASVFVLDTVRSNQMPSLGALYSAEHGLLLEKVGPELLPPPKHTFEVRAETDLKTICRAIQRFLLAYKEERRGPTLIAVQSSWELKRLASEIPVLEEFPLVPICVADKINYGVLDWQRHGARRMIRHYLNLDTCLSQAFEMSRYFHIPIGNLPEDISTFGSDLFFARHLQRHNHLLWLSPTARPDLGGKEADDNCLVMEFDDQATVEINSSGCYSTVCVELDLQNLAVNTILQSHHVNDMEGADSMGISFDVIQQASLEDMITGGQAASAPASYDETALCSNTFRILKSMVVGWVKEITQYHNIYADNQVMHFYRWLRSPSSLLHDPALHRTLHNMMKKLFLQLIAEFKRLGSSVIYANFNRIILCTKKRRVEDAIAYVEYITSSIHSKETFHSLTISFSRCWEFLLWMDPSNYGGIKGKVSSRIHCGLQDSQKAGGAEDEQENEDDEEERDGEEEEEAEESNVEDLLENNWNILQFLPQAASCQNYFLMIVSAYIVAVYHCMKDGLRRSAPGSTPVRRRGASQLSQEAEGAVGALPGMITFSQDYVANELTQSFFTITQKIQKKVTGSRNSTELSEMFPVLPGSHLLLNNPALEFIKYVCKVLSLDTNITNQVNKLNRDLLRLVDVGEFSEEAQFRDPCRSYVLPEVICRSCNFCRDLDLCKDSSFSEDGAVLPQWLCSNCQAPYDSSAIEMTLVEVLQKKLMAFTLQDLVCLKCRGVKETSMPVYCSCAGDFALTIHTQVFMEQIGIFRNIAQHYGMSYLLETLEWLLQKNPQLGH

Gene

Pole

Protein

DNA polymerase epsilon catalytic subunit A

Organism

Mus musculus

Length

2283 amino acids

Function

Participates in DNA repair and in chromosomal DNA replication.

Similarity

Belongs to the DNA polymerase type-B family.

Mass

262.1 kDa

Sequence

MVLRNSGRRHPEPGADGEGSRDDGPSSSVSALKRLERSQWTDKMDLRFGFERLKEPGERTGWLINMHPTEILDEDKRLVSAVDYYFIQDDGSRFKVALPYMPYFYIAARKGCDREVSSFLSKKFQGKIAKLENVPKEDLDLPNHLVGLKRSYIKLSFHTVEDLVKVRKEISPAVKKNREQDHASDEYTTMLSSILQGGSVITDEDETSKKIADQLDNIVDMREYDVPYHIRLSIDLRIHVAHWYNVRFRGNAFPVEITRRDDLVERPDPVVLAFDIETTKLPLKFPDAETDQIMMISYMIDGQGYLITNREIVSEDIEDFEFTPKPEYEGPFCVFNEPDEVHLIQRWFEHIQETKPTIMVTYNGDFFDWPFVEARAAIHGLSMYQEIGFQKDSQGEYKAPQCIHMDCLRWVKRDSYLPVGSHNLKAAAKAKLGYDPVELDPEDMCRMATEQPQTLATYSVSDAVATYYLYMKYVHPFIFALCTIIPMEPDEVLRKGSGTLCEALLMVQAFHANIIFPNKQEQEFNKLTDDGHMLDAETYVGGHVEALESGVFRSDIPCRFRMNPAAFDFLLQRVEKTMRHAIEEEEKVPVEQATNFQEVCEQIKTKLTSLKDVPNRIECPLIYHLDVGAMYPNIILTNRLQPSAIVDEATCAACDFNKPGASCQRKMAWQWRGEFMPASRSEYHRIQHQLESEKFPPLFPEGPARAFHELSREEQAKYEKRRLADYCRKAYKKIHVTKVEERLTTICQRENSFYVDTVRAFRDRRYEFKGLHKVWKKKLSAAVEVGDASEVKRCKNMEILYDSLQLAHKCILNSFYGYVMRKGARWYSMEMAGIVCFTGANIITQARELIEQIGRPLELDTDGIWCVLPNSFPENFVIKTTNAKKPKLTISYPGAMLNIMVKEGFTNHQYQELTEPSSLTYVTHSENSIFFEVDGPYLAMILPASKEEGKKLKKRYAVFNEDGSLAELKGFEVKRRGELQLIKIFQSSVFEAFLKGSTLEEVYGSVAKVADYWLDVLYSKAANMPDSELFELISENRSMSRKLEDYGEQKSTSISTAKRLAEFLGDQMVKDAGLSCRYIISRKPEGSPVTERAIPLAIFQAEPTVRKHFLRKWLKSSSLQDFDIRTILDWDYYIERLGSAIQKIITIPAALQQVKNPVPRVKHPDWLHKKLLEKNDIYKQKKISELFVLEGKRQIVMAQASENSLSLCTPDMEDIGLTKPHHSTVPVATKRKRVWETQKESQDIALTVPWQEVLGQPPSLGTTQEEWLVWLQFHKKKWQLQAQQRLALRKKQRLESAEDMPRLGPIREGPSTGLGSFLRRTARSIMDLPWQIIQISETRQAGLFRLWAIIGNDLHCIKLSIPRVFYVNQRVAKAEDGPAYRKVNRALPRSNIVYNLYEYSVPEDMYQEHINEINTELSVPDIEGVYETQVPLLFRALVQLGCVCVVNKQLTRHLSGWEAETFALEHLEMRSLAQFSYLEPGSIRHIYLYHHTQGHKALFGVFIPSQRRASVFVLDTVRSNQMPGLSALYSSEHSLLLDKVDPKLLPPPKHTFEVRAETNLKTICRAIQRFLLAYKEERRGPTLIAVQSSWELCRLTSEIPVLEEFPLVPIRVADKISYAVLDWQRHGARRMIRHYLNLDLCLSQAFEMSRYFHIPVGNLPEDISTFGSDLFFARHLQHHNHLLWLSPTSRPDLGGKEADDNRLVMEFDDRATVEINSSGCYSTVCVELDIQNLAVNTILQSHHVNDMEGAGSMGISFDVIQQASLEDMVTGNQAASALANYDETALCSSTFRILKSMVVGWVKEITQYHNIYADNQVMHFYRWLQSPCSLLHDPALHRTLHNMMKKLFLQLIAEFKRLGSSVVYANFNRIILCTKKRRIEDALAYVEYITNSIHSKEIFHSLTISFSRCWEFLLWMDPSNYGGIKGKVPSSIHCGQVKEQDSQAREETDEEEEDKEKDEEEEGMGESEVEDLLENNWNILQFLPQAASCQSYFLMIVSAYIVAVYQSMKEELRHSAPGSTPVKRKGASQFSQESEGATGSLPGMITFSQDYVANELTQSFFTITQKIQKKVTGSRNTTEPSEMFPVLPGSHLLLNNPALEFIKYVCKVLSLDTNITNQVNKLNRDLLRLVDVGEFSEEAQFRDPCHSYVLPEVICHSCNFCRDLDLCKDSSFSQDGAILPQWLCSNCQAPYDSSAIESALVEALQRKLMAFTLQDLVCLKCRGMKETHMPVYCSCAGDFTLTIRTEVFMEQIRIFQNIAKYYSMSYLQETIEWLLQTSPVSNC