Organism
Deinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422)
Function
A DNA polymerase, required for DNA repair after DNA damage induced by ionizing radiation (IR); this is not the major DNA polymerase (PubMed:19303848). Following severe irradiation (7 kGy of gamma irradiation) genomic DNA is fragmented. DNA is progressively degraded for the first 1.5 hours after IR, in a step promoted by RecA and counterbalanced by DNA Pol I and Pol III, followed by massive DNA synthesis and genome reassembly in the next hour. Optimal priming of DNA synthesis requires both RecA and RadA, Pol III initiates DNA synthesis while both Pol I and Pol III are required for its contination (PubMed:19303848). May also have 5'-3' exonuclease activity (By similarity).
Similarity
Belongs to the DNA polymerase type-A family.
Sequence
MVFCGDGGLSCESIDFALCCLRGRSGNYVQSRILPMADASPDPSKPDTLVLIDGHALAFRSYFALPPLNNSKGEMTHAIVGFMKLLLRLARQKSNQVIVVFDPPVKTFRHEQYEGYKSGRAQTPEDLPGQINRIRALVDALGFPRLEEPGYEADDVIASLTRMAEGKGYEVRIVTSDRDAYQLLDEHVKVIANDFSLIGPAQVEEKYGVTVRQWVDYRALTGDASDNIPGAKGIGPKTAAKLLQEYGTLEKVYEAAHAGTLKPDGTRKKLLDSEENVKFSHDLSCMVTDLPLDIEFGVRRLPDNPLVTEDLLTELELHSLRPMILGLNGPEQDGHAPDDLLEREHAQTPEEDEAAALPAFSAPELAEWQTPAEGAVWGYVLSREDDLTAALLAAATFEDGVARPAPVSEPDEWAQAEAPENLFGELLPSDKPLTKKEQKALEKAQKDAEKARAKLREQFPATVDEAEFVGQRTVTAAAAKALAAHLSVRGTVVEPGDDPLLYAYLLDPANTNMPVVAKRYLDREWPADAPTRAAITGHLLRELPPLLDDARRKMYDEMEKPLSGVLGRMEVRGVQVDSDFLQTLSIQAGVRLADLESQIHEYAGEEFHIRSPKQLETVLYDKLELASSKKTKLTGQRSTAVSALEPLRDAHPIIPLVLEFRELDKLRGTYLDPIPNLVNPHTGRLHTTFAQTAVATGRLSSLNPNLQNIPIRSELGREIRKGFIAEDGFTLIAADYSQIELRLLAHIADDPLMQQAFVEGADIHRRTAAQVLGLDEATVDANQRRAAKTVNFGVLYGMSAHRLSNDLGIPYAEAATFIEIYFATYPGIRRYINHTLDFGRTHGYVETLYGRRRYVPGLSSRNRVQREAEERLAYNMPIQGTAADIMKLAMVQLDPQLDAIGARMLLQVHDELLIEAPLDKAEQVAALTKKVMENVVQLKVPLAVEVGTGPNWFDTK