Protein
Proline-rich nuclear receptor coactivator 2 B
Function
Involved in nonsense-mediated mRNA decay (NMD) by acting as a bridge between the mRNA decapping complex and the NMD machinery. May act by targeting the NMD machinery to the P-body and recruiting the decapping machinery to aberrant mRNAs. Required for upf1/rent1 localization to the P-body. Also acts as a nuclear receptor coactivator (By similarity).
Similarity
Belongs to the PNRC family. PNRC2 subfamily.
Sequence
MGGGERFNIPGQHRNNLGKQIARQKLFDRNNQKMSMSHTKDRSRGCGTSLAWQAMQNGVNNNTLSSNQNWSAGFPASNNLFTNQDNQNYAGAKFSEPPSPSVLPKPPSHWVLLSCSPAEKELMSFQLKTLLKVQA