pncA

Gene

pncA

Protein

Nicotinamidase

Organism

Escherichia coli (strain K12)

Length

213 amino acids

Function

Is also able to hydrolyze the first-line antituberculous drug pyrazinamide (PZA) into pyrazinoic acid in vitro, but this reaction is not considered to be physiologically relevant.

Similarity

Belongs to the isochorismatase family.

Mass

23.362 kDa

Sequence

MPPRALLLVDLQNDFCAGGALAVPEGDSTVDVANRLIDWCQSRGEAVIASQDWHPANHGSFASQHGVEPYTPGQLDGLPQTFWPDHCVQNSEGAQLHPLLHQKAIAAVFHKGENPLVDSYSAFFDNGRRQKTSLDDWLRDHEIDELIVMGLATDYCVKFTVLDALQLGYKVNVITDGCRGVNIQPQDSAHAFMEMSAAGATLYTLADWEETQG

Protein

Nicotinamidase: pncA

Gene

pncA

Protein

Nicotinamidase/pyrazinamidase

Organism

Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)

Length

186 amino acids

Function

Is involved in the activation of the first-line antituberculous drug pyrazinamide (PZA) by converting it into the active form, pyrazinoic acid.

Similarity

Belongs to the isochorismatase family.

Mass

19.605 kDa

Sequence

MRALIIVDVQNDFCEGGSLAVTGGAALARAISDYLAEAADYHHVVATKDFHIDPGDHFSGTPDYSSSWPPHCVSGTPGADFHPSLDTSAIEAVFYKGAYTGAYSGFEGVDENGTPLLNWLRQRGVDEVDVVGIATDHCVRQTAEDAVRNGLATRVLVDLTAGVSADTTVAALEEMRTASVELVCSS

Protein

Nicotinamidase/pyrazinamidase: pncA

Gene

pncA

Protein

Uncharacterized isochorismatase family protein PncA

Organism

Bacillus subtilis (strain 168)

Length

183 amino acids

Similarity

Belongs to the isochorismatase family.

Mass

20.523 kDa

Sequence

MKKALICIDYTNDFVASDGKLTCGEPGRMIEEAIVNLTKEFITNGDYVVLAVDSHDEGDQYHPETRLFPPHNIKGTEGKDLYGKLLPLYQKHEHEPNVYYMEKTRYSAFAGTDLELKLRERQIGELHLAGVCTDICVLHTAVDAYNKGFRIVVHKQAVASFNQEGHAWALSHFANSIGAQVAE

Protein

Uncharacterized isochorismatase family protein PncA: pncA