pmrA

Gene

pmrA

Protein

Multi-drug resistance efflux pump PmrA homolog

Organism

Lactococcus lactis subsp. lactis (strain IL1403)

Length

405 amino acids

Function

Efflux pump for various substrates.

Similarity

Belongs to the major facilitator superfamily. TCR/Tet family.

Mass

43.859 kDa

Sequence

MNRTKTVNWKRNLFITWIGCFFVGSSFSLVMPFLPLYIQGLGVSGGNVELYSGLAFSLPALASGLVAPIWGRLADEHGRKVMMVRASIVMTLTMGGIAFAPNVWWLLGLRLLMGFFSGYIPNSTAMIASQAPKDKSGYALGTLATAMVSGTLIGPSLGGLLAEWFGMANVFLIVGALLALATLLTIFFVHENFEPIAKGEMLSSKEIINKVSNKQILFGLLVTTFIIQITSQSIEPFVTLYIKTLTTSTNNLMFISGLIVSAVGLSAMLSSSFLGRLGDKYGSHRLILIGLVFTFIIYLPMAFVQSPLQLGILRFLLGFGTGALTPSVNSLLSKITPKEGVSRIFAYAQMCSNLGMVTGPLVGSAIAGYISYRAAIVGTSLFVIVNIIWSFINFRKYLRKRSIME

Protein

Multi-drug resistance efflux pump PmrA homolog: pmrA

Gene

pmrA

Protein

Multi-drug resistance efflux pump PmrA

Organism

Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)

Length

399 amino acids

Function

Efflux pump for various substrates.

Similarity

Belongs to the major facilitator superfamily. TCR/Tet family.

Mass

42.84 kDa

Sequence

MTEINWKDNLRIAWFGNFLTGASISLVVPFMPIFVENLGVGSQQVAFYAGLAISVSAISAALFSPIWGILADKYGRKPMMIRAGLAMTITMGGLAFVPNIYWLIFLRLLNGVFAGFVPNATALIASQVPKEKSGSALGTLSTGVVAGTLTGPFIGGFIAELFGIRTVFLLVGSFLFLAAILTICFIKEDFQPVAKEKAIPTKELFTSVKYPYLLLNLFLTSFVIQFSAQSIGPILALYVRDLGQTENLLFVSGLIVSSMGFSSMMSAGVMGKLGDKVGNHRLLVVAQFYSVIIYLLCANASSPLQLGLYRFLFGLGTGALIPGVNALLSKMTPKAGISRVFAFNQVFFYLGGVVGPMAGSAVAGQFGYHAVFYATSLCVAFSCLFNLIQFRTLLKVKEI

Protein

Multi-drug resistance efflux pump PmrA: pmrA

Gene

pmrA

Protein

Multi-drug resistance efflux pump PmrA

Organism

Streptococcus pneumoniae (strain ATCC BAA-255 / R6)

Length

399 amino acids

Function

Efflux pump for various substrates.

Similarity

Belongs to the major facilitator superfamily. TCR/Tet family.

Mass

42.84 kDa

Sequence

Protein

Multi-drug resistance efflux pump PmrA: pmrA

Gene

pmrA

Protein

Transcriptional regulatory protein PmrA

Organism

Pectobacterium parmentieri

Length

222 amino acids

Function

Member of the two-component regulatory system PmrB/PmrA involved in regulation of virulence. Unphosphorylated PmrA represses extracellular enzyme genes. Phosphorylation of PmrA by PmrB relieves such repression, which leads to activation of extracellular enzyme genes. Phosphorylated PmrA seems to repress expression of the pmrCAB operon.

Mass

24.868 kDa

Sequence

MKLLIVEDDKLLQEGLLLALSHEGYACDCAGTAKEADALIGSAHYSLVILDLGLPDDDGLALLSRWRKNNYQHPVLILTARDKVDDRVSGLDVGADDYLAKPFALTELQARVRALIRRNQGSSNSKIQVDNITLDLNNQQVLLDEKPVVLTPKEFAILSRLVLKAGYQVHRELLHQDIYAWNDDPSSNSLEVHIHNLRQKIGKDRIRTLRGFGYLLTKGEQP

Protein

Transcriptional regulatory protein PmrA: pmrA

Gene

pmrA

Protein

Multi-drug resistance efflux pump PmrA homolog

Organism

Lactococcus lactis subsp. cremoris

Length

119 amino acids

Similarity

Belongs to the major facilitator superfamily.

Mass

13.041 kDa

Fragment

single

Sequence

ILIGLVFTFVIYLPMAFVQSPLQLGILRFLLGFGAGALMPSVNSLLSKITPKEGVSRIFAYAQMCSNLGMVTGPLVGSAIAGYISYRAAIVGTSLFVIVNIIWSFINFRKYLRKRSIME

Protein

Multi-drug resistance efflux pump PmrA homolog: pmrA