About Products Protein Database Contact

plr-1

Gene
plr-1
Protein
Probable E3 ubiquitin-protein ligase plr-1
Organism
Caenorhabditis elegans
Length
487 amino acids
Function
Probable E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination, endocytosis and subsequent degradation of Wnt receptor complex components Frizzled (By similarity). Acts on both canonical and non-canonical Wnt signaling pathway (By similarity). Plays a role in the migration and axon guidance of different neuronal cell types including CAN, HSN, AVK and AVG (PubMed:24401370, PubMed:25448694). Promotes the differentiation and regulates the anteroposterior polarity of AVG unpaired interneurons by sequestering the Wnt signaling proteins cfz-2, mig-1 and mom-5 to endosomes which thereby reduces their cell surface expression and negatively regulates Wnt signaling (PubMed:24401370). May also regulate AVG polarity and axon guidance through Wnt-independent mechanisms involving unc-53/Nav2, unc-73/Trio and cytosolic protein vab-8 (PubMed:25448694).
Similarity
Belongs to the ZNRF3 family.
Mass
54.947 kDa
Sequence
MRLLLFILLNTTLLSTNYVHARPSVSHTTLASQFKFAEKADIFVTHTNINEDRTQDEKTIKLSGTFSPVGSNYETGGDIVQVSSFRACDARRKGLDNTVFEHVPVVFYDDVEKFLTGCVALDNQARFAEKSGAMALIVGPASRVERTTRPMMIGGSKIPVIVLDDEQTERLRSELRSASERGAVTKLRISFIDEKPTKVLKLQVFRPTVLNITLLGLLIILIVFVSLLVVVKIRCQPTMHRELWLRALARTALTKMEIRSFQKEKNVEAGQKKKTSSTFARLKQHRSSSSRHSSYLAVFGSLTSVAQSSSHSAQERCVICLEEYEEGTELRVLFCGHEFHPKCVDPWLLSKRRCPLCQFDVVYKHYPKVDSPEKLSGRSDDTTSLLPRTSPSEDLPSAPSSRSTRLTRPYRTTHHLIPSSTRPSSHQRPSLQPTAPRTRSCPRRRQLRSRNQIDFSIRIGGYSSDVSSSHAEQSRSFEIEPRTSQQL

Gene
PLR-1
Protein
Protein tyrosine phosphatase PRL-1
Organism
Trypanosoma cruzi (strain CL Brener)
Length
176 amino acids
Function
Has protein tyrosine phosphatase activity.
Similarity
Belongs to the protein-tyrosine phosphatase family.
Mass
19.237 kDa
Sequence
MGANGTLVECKRGESDAVVFRFLIFDAPSPSSVTAYVKLMQKYNVRHIVRACGQTYSAEAFEKQGMVVHGWSFDDGAPPTQTVIDNWLNLLEQEKNKSPPETIAVHCVAGLGRAPILVALALVEYGGMPPLDAVGYVRGRRKGAINQVQLNWLMRYKPRHQEGNEGSLSCAGCAVM