Function
Probable E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination, endocytosis and subsequent degradation of Wnt receptor complex components Frizzled (By similarity). Acts on both canonical and non-canonical Wnt signaling pathway (By similarity). Plays a role in the migration and axon guidance of different neuronal cell types including CAN, HSN, AVK and AVG (PubMed:24401370, PubMed:25448694). Promotes the differentiation and regulates the anteroposterior polarity of AVG unpaired interneurons by sequestering the Wnt signaling proteins cfz-2, mig-1 and mom-5 to endosomes which thereby reduces their cell surface expression and negatively regulates Wnt signaling (PubMed:24401370). May also regulate AVG polarity and axon guidance through Wnt-independent mechanisms involving unc-53/Nav2, unc-73/Trio and cytosolic protein vab-8 (PubMed:25448694).
Sequence
MRLLLFILLNTTLLSTNYVHARPSVSHTTLASQFKFAEKADIFVTHTNINEDRTQDEKTIKLSGTFSPVGSNYETGGDIVQVSSFRACDARRKGLDNTVFEHVPVVFYDDVEKFLTGCVALDNQARFAEKSGAMALIVGPASRVERTTRPMMIGGSKIPVIVLDDEQTERLRSELRSASERGAVTKLRISFIDEKPTKVLKLQVFRPTVLNITLLGLLIILIVFVSLLVVVKIRCQPTMHRELWLRALARTALTKMEIRSFQKEKNVEAGQKKKTSSTFARLKQHRSSSSRHSSYLAVFGSLTSVAQSSSHSAQERCVICLEEYEEGTELRVLFCGHEFHPKCVDPWLLSKRRCPLCQFDVVYKHYPKVDSPEKLSGRSDDTTSLLPRTSPSEDLPSAPSSRSTRLTRPYRTTHHLIPSSTRPSSHQRPSLQPTAPRTRSCPRRRQLRSRNQIDFSIRIGGYSSDVSSSHAEQSRSFEIEPRTSQQL