plcd3a

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3-A

784 amino acids

Hydrolyzes the phosphatidylinositol 4,5-bisphosphate (PIP2) to generate 2 second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). DAG mediates the activation of protein kinase C (PKC), while IP3 releases Ca(2+) from intracellular stores (By similarity).

89.381 kDa

MLGRKKNPETVQTESKSVESKTHDPLRRLGVLDDEDVLLMLQGSKMMKVRSQRWRKDRRLKLLEDCVTVWCESSKTSRKSNRQQTFSVTEVECVREGCQSECLRRMTDLVPEKNCFTVVFRGGRKSLDLCCHTQEEAERWVRGIRTLKDRVSNMSQKEKLDHWIRGYLRRADQNQDGKMSYDEVKHLLQLINIDLNEQYARTLFKKCDRSCDGRLDHVEIEEFCREMMRRPELDAVFRHYSGNGCVLTTLELRDFLGDQGEDASLVHAKSLIQTFELNDWAQKNLFMTQNGFTMYMLSKENDVFNPDHTHVYQDMSKPLAHYYISSSHNTYLTKDQVTSASSTEPYIRALNQGCRCVELDCWDGDKGEPIIYHGHTLTSKVLFKEVIETIAQYAFKASPYPLILSLENHCSVEQQAIMAQQLQSILGKKLLAKPLSDLPLKQLPSPEELKGRILLKGKKLNGLLGKTESWTSFTNSSDEESVAGGNKKESKKDLARSASTKLSPELSDLVVYCQSVPFSGFETANQRPPSVITSFSENEALKLIKDSGKLFVRNNSRQLSRIYPSAQRLQSSNFDPQDMWNAGCQMVALNFQTPGEQMDLNQGRFLPNGRCGYVLKPEFLCDPKSDFDPENTGGGPGHIPTQLTIRVISAQQLPKINTDKPNSIVDPQVWVEIHGVSIDKARAKTQRIDNNGFNPRWDCTVSFQLQLPELALVRFMVEDHDHKSKNDFIGQFTLPFTSLRTGYRHVHLLKADGSTLSPATLFIHVKVVRRGVHIKTVSERIGKA