Protein
Polyketide synthase PksM
Organism
Bacillus subtilis (strain 168)
Function
Involved in some intermediate steps for the synthesis of the antibiotic polyketide bacillaene which is involved in secondary metabolism.
Sequence
MITEQLHISLNNPIMSNHKVYGQALLPGLAYIDLIYQVFQEHGYAYQELELKNLTIFYPLIADESYDIALTIHVSERKEGTWSIIIDGQKQHGESLSDKRQYVTADMHRKEQTAFAESIDLNQWKSTADRILNLDEIYEQCRSQELVHTGMMKAEGQIYEAKEGAVIDLAVGQEALRHSDAFLFHPTLIDGSGIGSSCLISDQTMYLPLYYESFSASERLQKGCTARILSSSVRQKKELTYMTIEYFNSAGQKVAELKQFAGKSVRNMSAFHSAKEIQEERAAVSQNISRDYPAFEMYLRQLLAKQLERPAEQMDIHAGYYELGLDSSSLLTVVQEIGDKVGADLAPTLLFEFTTIAELAAHLADHYSIGEADDAVRQSPSPIDGVTSSPEIGEDIAIIGMAGRYPKAKNIQEFWEQLKAGTDCITEIPNSRWEWKESDGLDSPAGKPLSKWGGFIEEADCFDPQFFRISPREAEMMDPQERLFLETCWEAIEDAGYTPETIASPQGENKRQHVGVFAGVMHKDYSLIGAEALSEHNPFPLSLNYAQIANRVSYYCNFHGPSMAVDTVCSSSLTAVHLAIESIRNGECEAALAGGVNLSLHPAKYISYGSVGMHSSDGYCHTFGKGGDGYVSGEGVGTVLLKPLRKAEQDGDRIYAVIKGSAINHVGKVSGITVPSPVAQADVIEACLEKTGIDPRTISYVEAHGTGTSLGDPIEVQGLVKAFSRNTQDKQFCSIGSVKSNIGHAEAAAGISGLTKTVLQLHHKTLVPSLHSEELNPYLKLDQTPFFVQHETKEWEQPSFTENGVDVTYPRRAGLSSFGASGSNAHLILEEYIPAESHSETILTKNEEIVIPLSARNKDRLQAYALKLLDFLSEDVNLLALAYTMQAGRVEMEERAAFIVKDIKDLTAKLRAFANGEEEIEGCWTGRAKENQEAAGLASVNALNNNLIRDSEMMEMAKAWVQGKRVTWDDLYGDRKPLKISVPTYPFARERYWISVPEMKTSTVNHILHPLVHRNTSDFTEQRFSSVFTGTEFFLSDHVVQGQKILPGVAYLEMAREAAEKAAGDLDGEQRVVSLKDIVWVRPITIESEPKEIHIGLFPEDNGDISFDIYSSSEHKEEALTIHCQGRAVISDEAETSILNLSSIQTECSLDTVTSEQCYAAFRKIGLDYGEGYQGIEKVYVGKDQLLAKISLPAFLKNDKQHFALHPSLMDSAFHATVGFIVSSVNAAGQAQTLSLPFALQEVDIFSPCPEKIWSYIRYSSDSKAENKVRKYDIDLCDENGRVCVRMKGASMRALDGEQHSKPQLLTDSQLTGHTVMIPVWEPVSLEAEDNASFAGKRAVLCGAAEADRTFIKHHYPQISFVDIRPADDIEAIADKLQAYGSIDHVLWIAPSHRGSIGSDGQEEAVLHLFKLVKACLQLGYGEKQLEWSLVTVQAQPVTQHEAVQPAHASIHGLAGTMAKEYPHWKIRLLDLEKGCTWPVNHMFALPADRLGHAWAYRNQQWHQQQLIPYRSSLSGDTLYRKGGVYVVIGGAGYIGEAWSEYMIRRYQAQIVWIGRSQLNAAIQSKIDRLSALGPEPFYIAADAADKHSLQQAYEQVKKRHPHIHGIVHSAMVLFEQSLEKMKPEEFTAGLAAKIDVSIRMAQVFRQENVDFVLFFSSLVAHIKNVKQSHYASGCTFADAFAHQLSQSWACPVKVMNWGYWGNSEAAEDEHYVQLMNQIGLGLIEPAEAMKALEALLSGPVSQTAFIHTTKPVAVEGVNQNEFITLYPEQPSADAESLMERLPTTGRFQRVTHEELDDLLYRLLLGQLQTAELFDGYTLSVERLQQYKTREFYGKWIRQSSEFLLQHGYLKKVGDSLVRKDQAEDIELLWLEWNAKKEKWLKDSETKAMVVLAEAMLQALPDILTGKVPATDIMFPHSSMELVEGIYKHNQVADYFNKVLADTLLAYLDERLKHDPEASIRIMEIGAGTGGTSAGIFEKLKPYQKHINEYCYTDLSKAFLLHAEKEYGAENPYLTYQLFDVEKPIDQQEFEAGGYDVVIAANVLHATKNIRQTLRHTKAVMKNNGMLLLNEMAGNSLFPHITFGLLEGWWLYEDPAVRIPGCPGLHPDSWKAALESEGFESVFFPAEAAHDLSHQIVAASSNGLVRRMMKNVILPEKVVSQASNQEPAYIHTIDSEEAGQSKHALLREKSTEYMKKLIGETLKIPAGKIESSEPLEKYGIDSIVVVQLTNTLRKEFDHVSSTLFFEYQTIDALVEHFIKTKTEALMKLTGLDRQVQQHTPAESRTQSSQKPDQAAKRTRRFRKLGFSGEKETPTNTLASRDVAVIGISGRYPQAETAEDFWNNLKEGRNCIEEIPKDRWDWKAYYDKEKGKEGSIYTKWGGFIKDMDKFDPLFFQISPLEAERMDPQERLFLQTAYASIEDAGYTPDSLCSSRKIGVFAGVMNKNYPTGYGYWSIANRISYLLNFQGPSLAVDTACSSSLTAIHLALESIYSGSSDCAIAGGVNLVVDPVHYQNLSVMNMLSASDTCKSFGDDADGFVDGEGVGAIVLKPLQQAIADGDHIYGVIKASAINSGGKTNGYTVPNPHAQAQVIKEAIERADIPARTISYLEAHGTGTALGDPIEIAGLTKAFEKDTQEKQFCAIGSSKSNIGHCESAAGIAGLTKILFQFKYGQIAPSLHAQRLNPNIEFSHTPFVVQQQLGEWKRPVIGGQEVPRRAGLSSFGAGGSNAHIILEEYIPRTGAQTPKDHPPALIVLSAKNMERLQEKAEQLLTAIKQKRYCETDLIRIAYTLQTGREAMEERLAFIAESLEDLERKLNDFIENKADSLYLDRIDDNKKALAVLSADEDTEKIIEAWMSKGKYTKLLDLWVKGLSFDWGMLYGTQTPVRISLPAYPFAKERYWAPGAAKAPVSIEQDHDQQTEEPFKVMTFQEVWKEEPATLTSKRIKTLICFLTEREKQNAFASALKNVDQDTKVIFISQGEVYSKQSEYSYQIVRQEPVTFEKAFQSIKEELGEPDAILYMWPMEDKRCIKDHSCIVYLLQGMSAAKLHPSRLLLAGCFEDSLDRSYLESWIGFERSLGLVLPHTKVTGIFQPAEQGSMDDWTRKVWAELQASTEQTVLYQNLKRYVNHIEQTTIQPDNSKLKSGGTYLITGGVGGLGYLFAKHLAKNYAANLILTGRSPFNDEKQKQIKELKDLGGEAMYAEADVSDPIAMGDCVKRGKDRFGAINGVIHAAGIESDSAIFDKKIESFQRIIEPKINGTIALDEWLKNEDLDFMCYFSSSSAVLGDFGCCDYAIGNRFQMAYAQYRNELHNGKTFVINWPVWKDGGMKIGDEETTDMYLKSSGQRFLEAEEGIRMFEHILAQQDAQHLVIAGQPSRVSRFLGMTEPAIPEPATQAPLAQENKDEVKTLSIEKRLEHDLKEHIHTLLKISKDKLNLNKNWADFGFDSIYLAKFSNVLSKHFNIEVTPALFFGYSTLQELISFFLTDHKELIEAFYRDDASEAQKPPEAYAVIPVALEPEASKKSIRQVHDEPIAIIGMSGRFPQADSVHELWDNLKNGKSCISDIPGERRDWGRANRDPEKAVPRWGAFLKDIDRFDPLFFQISPKEAESMDPRQRIFLEEAWHTFEDAGYMGDRIKGKSCGVYVGVEEGEYAHLTGDTDYINGTQNATLSARIAYALDLKGPNMALTAACSSGLVAIHQACSALRQGDCEMALAGGVSLNISHMSFEALTRAEMLSPNGQCKVFDQDANGLVPGEAVAAVLLKPLSKAIEDKDHIYGCIKASGVNYDGKTNGITAPNPFSQAELIENIYEKNEINPLDIQYVMAHSTGSNLGDPLEVQALTSVFSKYTKQKQFCMISSIKPLIGHTFAASGTVALISMLMAMKNQIIPATHHCESENPYIPFKESPFVLCKENRSWIKKNQKPRMGTISTTGISGTNAHAVIEEYIPDDQPSTQRHQGSPQIFVISAQNDDRLQDAACRMIAYLEQNHNLSLPDVAYTLQVGRKAMEARLAIVANNQEQLVRKLKEYVEAMKNGGVSGQQRSLYTGYTEGILEEQDEAVLQALAKERNLENIAECWVKGYQIPWELLHDGDDVRMVSLPGYPFARERYWISSGTQQSEAVKQHSQDMKTEIDEPNGKTHIQKIIVQFLARELGISEDRINFKRNFLDYGMDSILGRKLMRHIEKTTQLKMAGREILECQTVQALSDHLALKAEKQNHSAAAHHIKGTYTDEQIIGLMQEVALGKLDFKSVQNIIEGSKSYES