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pilY1

Gene
pilY1
Protein
Type IV pilus biogenesis factor PilY1
Organism
Pseudomonas aeruginosa (strain PAK)
Length
1163 amino acids
Function
Involved in pilus assembly, twitching motility and adhesion to host cells. Primes type IV pili (T4P) assembly and is required for inclusion of minor pilins PilV, PilW and PilX to the surface pili (By similarity). Stabilizes assembled pilus fibers likely by antagonizing retraction mediated by PilT. Calcium-binding and calcium release by PilY1 seem to be essential for twitching motility and for regulation of pilus retraction dynamics of PilT. Adhesin for human tissue specifically recognizing a host receptor localized or enriched on basolateral epithelial cell surfaces. Binds host integrins in an calcium-dependent manner in vitro and this interaction may be employed by the bacterium to mediate host epithelial cell binding in vivo.
Similarity
Belongs to the PilY1 family.
Mass
126.248 kDa
Sequence
MKSALHQIGKTSLAAALSGAVLLSAQTTHAAALSVSQQPLMLIQGVAPNMLVTLDDSGSMAYAYAPDSLVNSRNNVYFASNSYNPMYFDPNTQYKLPKKVTLSNGQIQVQDYSKPSFTAAWRNGFTQEGRVNLSRDYRPTVQYQGGSGAGTESSIDWYGAPAFYYQYSGGRGCSLTTSSCYTRVEISGAAQQQNFANWYSFYRTRALATQTAANLAFYSLPENARISWQLLNSSSCLIGSGSSNCYNNYLRDFTGQHRVNFFNWLENLSVGGGTPLRQAMTRAGEFLKKTGVNGPYAYRPGTQTSPEYSCRGSYHILMTDGLWNNDSASVGNADSTSRSLPDGKSYSSQTPYRDAASNTLADQAFHYWATDARPDIDDNIKPYIPYPDQANPSAEYWNPRNDPATWQHMVTYTLGLGLTTSLTSPKWEGSTYSGGYDEIAAGRLSWPNASNNHSNNVYDLWHAAVNSRGEFFSADSPDQLVAAFQDILNRISGKDLPASRPAISSSLQEDDTGDKLTRFAYQTSFASDKNWAGDLTRYSLTTQDKATVQTKLWSAQSILDAMPNGGAGRKIMMAGSGTSGLKEFTWGSLSADQQRQLNRDPDRNDVADTKGQDRVAFLRGDRSKENSDNFRTRNSILGDIINSSPATVGKAQYLTYLAQPIEPSGNYSTFAEAQKTRAPRVYVGANDGMLHGFDTDGNETFAFIPSAVFEKLHKLTARGYQGGAHQFYVDGSPVVADAFFGGAWHTVLIGSLRAGGKGLFALDVTDPANIKLLWEIGVDQEPDLGYSFPKPTVARLHNGKWAVVTGNGYSSLNDKAALLIIDLETGAITRKLEVTGRTGVPNGLSSPRLADNNSDGVADYAYAGDLQGNLWRFDLIAGKVNQDDPFSRANDGPAVASSFRVSFGGQPLYSAVDSAGAAQAITAAPSLVRHPTRKGYIVIFGTGKYFENADARADTSRAQTLYGIWDQQTKGEAAGSTPRLTRGNLQQQTLDLQADSTFASTARTIRIASQNPVNWLNNDGSTKQSGWYLDFMVNGTLKGEMLIEDMIAIGQVVLLQTITPNDDPCADGASNWTYGLDPYTGGRTSFTVFDLARQGVVDSKSDYSYNKQNVAVSGTEQKGLGGLTLSTNEQGNPEVCSSGECLTVNPGPNTRGRQNWRPIEGKN

Gene
pilY1
Protein
Type IV pilus biogenesis factor PilY1
Organism
Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Length
1161 amino acids
Function
Involved in pilus assembly, twitching motility and adhesion to host cells. Primes type IV pili (T4P) assembly and is required for inclusion of minor pilins PilV, PilW and PilX to the surface pili (PubMed:25389296). Stabilizes assembled pilus fibers likely by antagonizing retraction mediated by PilT. Calcium-binding and calcium release by PilY1 seem to be essential for twitching motility and for regulation of pilus retraction dynamics of PilT (By similarity).
Similarity
Belongs to the PilY1 family.
Mass
126.584 kDa
Sequence
MKSVLHQIGKTSLAAALSGAVLLSAQTTHAAALSVSQQPLMLIQGVAPNMLVTLDDSGSMAFAYAPDSISGYGNYTFFASNSFNPMYFDPNTQYKLPKKLTLVNGQVQIQDYPAPNFSSAWRNGFTRSGSINLSNSYKVTIEYGRGYDKESTIKADAAYYYDFTGSSSCNRTNQACYTRRYVSTEQRQNFANWYSFYRTRALATQTAANLAFYSLPENARVSWQLLNDSNCNQMGSGSSSGNCFSNYLRDFTGQHRVNFFNWLEKLSVNGGTPLRQAMTRAGEFLKKTGVNGPYAYRPGTQTAPEYSCRGSYHILMTDGLWNNDSANVGNADSTARNLPDGKSYSSQTPYRDGTFDTLADQAFHYWATDARPDIDDNIKPYIPYPDQANPSAEYWNPRNDPATWQHMVTYTLGLGLTTSLTSPRWEGSTFSGGYNDIVAGNLSWPRASNNDSNNVYDLWHAAVNSRGEFFSADSPDQLVAAFQDILNRISGKDLPASRPAISSSLQEDDTGDKLTRFAYQTSFASDKNWAGDLTRYSLTTQDKATVQTKLWSAQSILDAMPNGGAGRKIMMAGSGTSGLKEFTWGSLSADQQRQLNRDPDRNDVADTKGQDRVAFLRGDRRKENSDNFRTRNSILGDIINSSPATVGKAQYLTYLAQPIEPSGNYSTFAEAQKTRAPRVYVGANDGMLHGFDTDGNETFAFIPSAVFEKLHKLTARGYQGGAHQFYVDGSPVVADAFFGGAWHTVLIGSLRAGGKGLFALDVTDPANIKLLWEIGVDQEPDLGYSFPKPTVARLHNGKWAVVTGNGYSSLNDKAALLIIDLETGAITRKLEVTGRTGVPNGLSSPRLADNNSDGVADYAYAGDLQGNLWRFDLIAGKVNQDDPFSRANDGPAVASSFRVSFGGQPLYSAVDSAGAAQAITAAPSLVRHPTRKGYIVIFGTGKYFENADARADTSRAQTLYGIWDQQTKGEAAGSTPRLTRGNLQQQTLDLQADSTFASTARTIRIASQNPVNWLNNDGSTKQSGWYLDFMVNGTLKGEMLIEDMIAIGQVVLLQTITPNDDPCADGASNWTYGLDPYTGGRTSFTVFDLARQGVVDSKSDYSYNKQNVAVSGTEQKGLGGLTLSTNEQGNPEVCSSGECLTVNPGPNTRGRQNWRPIEGKN

Gene
pilY1
Protein
Type IV pilus biogenesis factor PilY1
Organism
Pseudomonas aeruginosa (strain UCBPP-PA14)
Length
1158 amino acids
Function
Involved in pilus assembly, twitching motility and adhesion to host cells. Primes type IV pili (T4P) assembly and is required for inclusion of minor pilins PilV, PilW and PilX to the surface pili. Stabilizes assembled pilus fibers likely by antagonizing retraction mediated by PilT. Calcium-binding and calcium release by PilY1 seem to be essential for twitching motility and for regulation of pilus retraction dynamics of PilT (By similarity). Regulates surface-activated virulence possibly by acting as a surface-attachment mechanosensor (PubMed:25385640).
Similarity
Belongs to the PilY1 family.
Mass
126.693 kDa
Sequence
MIHQITRAGKSLLAAGCTLSILFASDSYAATALNVSQQPLFLTQGVAPNLLFTLDDSGSMAWAYVPDGISGNSGRAGRSSDYNALYYNPDYAYQVPKKLTLSGDQIIVSDYPVPRFTAAWQDGYAQGSTTNLSNNYRPQWGTGWLGCIDSSCNTGRAYYYTYKVSASCPAQPVSSSNSCYTYNALPTSQESNFAIWYSYYRNRILATKTAANLAFYSLPENVRLTWGALNTCSIGANSRSCQNNALLQFNKQHKINFFNWLANSPASGGTPLHAALDRAGRFLQTNGTAYTTEDGKTYSCRASYHIMMTDGIWNGRNVTPGNLDNQNQTFPDSTLYRPQPPYADSNASSLADLAFKYWTTDLRPSIDNDLKPFMAYKSGDDSKDYWDPRNNPATWQHMVNFTVGLGLSYSLTLNSAPTWTGSTFGNYEELMAGSKAWPSVDNDAAPGNVYDLWHAAINSRGDFFSAESPDSLVQAFNKILTRISERNTSSSKPAMTSALQDDGTGDKLIRYSYQSSFASDKNWAGDLIRYKVESTSTGSTKTQEWSAGALLDNRAPATRNIYIASNSGTNRLKPFTWSNIEGSQLATWLNRNPDKDNQADTKGAQRVDFIRGQQNMDGFRQRQAVLGDIVHSSPAVVGPAQYLTYLANPIEPSGDYGTFKTEADQRSPRVYVGSNDGMLHGFNIKTGVEEFAFIPTAVFEKLNKLTGISYQGGAHQYFVDATPVVSDAFFDGAWHTVLIGTLGAGGRGLFALDVTKPDDVKLLWEYDSSTDSDLGYTFSKPTVARLHSGQWAVVTGNGYGSDNDKAALLLIDLKKGTLIKKLEVQSERGIANGLSTPRLADNNSDGIADYAYAGDLQGNIWRFDLIGNTRNDDPDTNTSINPFKPGDVDPSAFRVSFSGAPLFRARADNNTRQPITAPPTLVRHPSRKGYIVIVGTGKYFEDDDAQADTSRAMTLYGIWDRQTKGESANSTPTIDRNALTAQTMTTEANSTFGSVNRNIRLISQNPVKWYKDGATGTANSDVASYGWRLNLEVNSSKKGEMMIEDMFAAGQVLLLQTLTPNDDPCDSGSTSWTYGLNPYTGGRTSFTVFDLKRAGIVDSGSDYNGSVVSAFQQDGLGGLAITQNEQRQSEACTGDECIIFNPSDKSNGRQTWRVVEEK