Protein
Phosphatidylinositol 3-kinase regulatory subunit alpha
Function
Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane.
Similarity
Belongs to the PI3K p85 subunit family.
Sequence
MSAEGYKYRALYPYKKEREEDIDLRVGDTLSVSRATLLALGCFAEGMEARPEQIGWLNGCNENTGQRGDFPGTYVEYLGRKRISPPTPKPRPPRPLPVAPGAARGEAEAQAFTLPDLAEQFSPPDIGPPVLIKLIEAIEKKGLESATLYRSQSSSSLTELRQILECDAASVDFEQFDIAILSDALKRYFLDLPHPVIPALMYSEMLSAARESISSDEYVQLLRKIIRCANVPQQYWLTLQYLLKHFFQLCQSSSKNLLSAKSLAEIFSPLLFRIQVSSSDSSEFSTQILEVLIASEWNEKQAAPALPPKPSKSTAVTNNGTNHVMSLQDAEWYWGDISREEVNEKLRDTTDGTFLVRDASTIMHGDYTLTLRKGGNNKLIKIFHRDGKYGFSDPLTFNSVVELITHYRNESLAQYNPKLDVKLLYPVSRFQQDQVVKEDSIDAVGKKLREYNVQFEEKNQEYDRLYEDYTRTSQEIQMKRTAIEAFNETIKIFEEQCQTQEKYSKEYIEKFRREGNEKEIQRLLHNYEKLKSRISEIVDSKRRLEEDLKKQTAENREIDKRMNSIKPDLIQLRKTRDQYLMWLTQKGVRQKKLNEWMGNENTEDQYSVVEEEDLPHQDERTWNVGNINRNQAENLLRGKRDGTFLVRESSKAGCFACSVMAEGEVKHCVINKTHTGFGFAEPYNLYSSLKELVLHYQYTSLVQHNDSLNVTLAHPVYAQQRR