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phxA

Gene
phxA
Protein
Photox toxin
Organism
Photorhabdus luminescens subsp. laumondii (strain DSM 15139 / CIP 105565 / TT01)
Length
408 amino acids
Function
Mono-ADP-ribosylates chicken skeletal alpha-actin and human non-skeletal beta- and gamma-actin. Mono-ADP-ribosylates 'Arg-177' of yeast actin, blocking its ability to polymerize. Does not possess NAD(+)-glycohydrolase activity, unlike most mART enzymes. Upon expression in S.cerevisiae almost completely inhibits growth.
Similarity
In the C-terminal section; belongs to the SpvB family.
Mass
45.857 kDa
Sequence
MEKIMPISPISGHMPLSQIQVPQHATTSPLLEQGNRLFEQSVRRGPLHFQSSSLKHLCAELRQLQNAPSSMQARRVQDAIQHWENHHPKEVMARSTRLAELKQALAEQGTVGRTLQSKVMATGPQVILKQPMPALPQSIAAQITKAQTGCTTTLVSSATAELIKHNQNNQQHIKDSDGRKPVNNMPPPPPPPMADKTQKVKKWVVNTDSKQLQALRYYSAQGYNLINTYLRGGEYVKHQAIETLLSRNYLHSNEPTPQEFDAGMRAYIQDVTEGLNELAITDHKKVYRGLKFDKSELKNLLDQYTTEGNIIAEKGFLSTSPDKAWVNDTILVINLESGHKGRILGDAAHFKGEAEMLFPPESKMLVEKVLNRDDKEFDSHFSNLRLTDDASADTTRIKRIINIKMLNE