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phnO

Gene
phnO
Protein
Aminoalkylphosphonate N-acetyltransferase
Organism
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Length
154 amino acids
Function
Aminoalkylphosphonate N-acetyltransferase which is able to acetylate a range of aminoalkylphosphonic acids, including (S)-1-aminoethylphosphonate ((S)-1AEP) and 2-aminoethylphosphonate, using acetyl-CoA as acetyl donor. Its physiological role in S.typhimurium is unclear. However, by acetylating (S)-1AEP, PhnO would protect against the deleterious effects of (S)-1AEP, a structural analog of D-alanine that has antibacterial properties.
Mass
17.933 kDa
Sequence
MILMRRREDVMPVCELRHATTEDTDSVYALICELLKNELDYQAFRDGFAANLLDPNVHYRLALRNGEVVGMISLHMQFHLHHANWIGEIQELVVLPPMRGQKIGSQLLAWAEEEARQAGAELTELSTNIKRRDAHRFYLREGYKQSHFRFTKAL

Gene
phnO
Protein
Aminoalkylphosphonate N-acetyltransferase
Organism
Escherichia coli (strain K12)
Length
144 amino acids
Function
Aminoalkylphosphonate N-acetyltransferase which is able to acetylate a range of aminoalkylphosphonic acids, including aminomethylphosphonate, (S)-1-aminoethylphosphonate and 2-aminoethyl- and 3-aminopropylphosphonate, using acetyl-CoA as acetyl donor. Is required for the utilization of aminomethylphosphonate and (S)-1-aminoethylphosphonate as a phosphate source via the C-P lyase pathway. Is also essential for the detoxification of (S)-1-aminoethylphosphonate, a structural analog of D-alanine that has bacteriocidal properties due to inhibition of cell wall synthesis (PubMed:23056305). Also acts as a N-epsilon-lysine acetyltransferase that catalyzes acetylation of several proteins (PubMed:30352934).
Mass
16.57 kDa
Sequence
MPACELRPATQYDTDAVYALICELKQAEFDHHAFRVGFNANLRDPNMRYHLALLDGEVVGMIGLHLQFHLHHVNWIGEIQELVVMPQARGLNVGSKLLAWAEEEARQAGAEMTELSTNVKRHDAHRFYLREGYEQSHFRFTKAL