PHF2

Lysine-specific demethylase PHF2

1096 amino acids

Lysine demethylase that demethylates both histones and non-histone proteins. Enzymatically inactive by itself, and becomes active following phosphorylation by PKA: forms a complex with ARID5B and mediates demethylation of methylated ARID5B. Demethylation of ARID5B leads to target the PHF2-ARID5B complex to target promoters, where PHF2 mediates demethylation of dimethylated 'Lys-9' of histone H3 (H3K9me2), followed by transcription activation of target genes. The PHF2-ARID5B complex acts as a coactivator of HNF4A in liver. PHF2 is recruited to trimethylated 'Lys-4' of histone H3 (H3K4me3) at rDNA promoters and promotes expression of rDNA.

Belongs to the JHDM1 histone demethylase family. JHDM1D subfamily.

120.775 kDa

MATVPVYCVCRLPYDVTRFMIECDACKDWFHGSCVGVEEEEAPDIDIYHCPNCEKTHGKSTLKKKRTWHKHGPGQAPDVKPVQNGSQLFIKELRSRTFPSAEDVVARVPGSQLTLGYMEEHGFTEPILVPKKDGLGLAVPAPTFYVSDVENYVGPERSVDVTDVTKQKDCKMKLKEFVDYYYSTNRKRVLNVTNLEFSDTRMSSFVEPPDIVKKLSWVENYWPDDALLAKPKVTKYCLICVKDSYTDFHIDSGGASAWYHVLKGEKTFYLIRPASANISLYERWRSASNHSEMFFADQVDKCYKCIVKQGQTLFIPSGWIYATLTPVDCLAFAGHFLHSLSVEMQMRAYEVERRLKLGSLTQFPNFETACWYMGKHLLEAFKGSHKSGKQLPPHLVQGAKILNGAFRSWTKKQALAEHEDELPEHFKPSQLIKDLAKEIRLSENASKAVRPEVNTVASSDEVCDGDREKEEPPSPIEATPPQSLLEKVSKKKTPKTVKMPKPSKIPKPPKPPKPPRPPKTLKLKDGGKKKGKKSRESASPTIPNLDLLEAHTKEALTKMEPPKKGKATKSVLSVPNKDVVHMQNDVERLEIREQTKSKSEAKWKYKNSKPDSLLKMEEEQKLEKSPLAGNKDNKFSFSFSNKKLLGSKALRPPTSPGVFGALQNFKEDKPKPVRDEYEYVSDDGELKIDEFPIRRKKNAPKRDLSFLLDKKAVLPTPVTKPKLDSAAYKSDDSSDEGSLHIDTDTKPGRNARVKKESGSSAAGILDLLQASEEVGALEYNPSSQPPASPSTQEAIQGMLSMANLQASDSCLQTTWGAGQAKGSSLAAHGARKNGGGSGKSAGKRLLKRAAKNSVDLDDYEEEQDHLDACFKDSDYVYPSLESDEDNPIFKSRSKKRKGSDDAPYSPTARVGPSVPRQDRPVREGTRVASIETGLAAAAAKLSQQEEQKSKKKKSAKRKLTPNTTSPSTSTSISAGTTSTSTTPASTTPASTTPASTSTASSQASQEGSSPEPPPESHSSSLADHEYTAAGTFTGAQAGRTSQPMAPGVFLTQRRPSASSPNNNTAAKGKRTKKGMATAKQRLGKILKIHRNGKLLL

Phf2

Lysine-specific demethylase PHF2

1096 amino acids

Lysine demethylase that demethylates both histones and non-histone proteins. Enzymatically inactive by itself, and becomes active following phosphorylation by PKA: forms a complex with ARID5B and mediates demethylation of methylated ARID5B. Demethylation of ARID5B leads to target the PHF2-ARID5B complex to target promoters, where PHF2 mediates demethylation of dimethylated 'Lys-9' of histone H3 (H3K9me2), followed by transcription activation of target genes. The PHF2-ARID5B complex acts as a coactivator of HNF4A in liver. PHF2 is recruited to trimethylated 'Lys-4' of histone H3 (H3K4me3) at rDNA promoters and promotes expression of rDNA (By similarity).

Belongs to the JHDM1 histone demethylase family. JHDM1D subfamily.

120.814 kDa

MATVPVYCVCRLPYDVTRFMIECDACKDWFHGSCVGVEEEEAPDIDIYHCPNCEKTHGKSTLKKKRTWHKHGPGPTPDVKPVQNGSQLFIKELRSRTFPSAEDVVSRVPGSQLTVGYMEEHGFTEPILVPKKDGLGLAVPAPTFYVSDVENYVGPERSVDVTDVTKQKDCKMKLKEFVDYYYSTNRKRVLNVTNLEFSDTRMSSFVEPPDIVKKLSWVENYWPDDALLAKPKVTKYCLICVKDSYTDFHIDSGGASAWYHVLKGEKIFYLIRPASANISLYERWRSASNHSEMFFADQVDRCYKCTVKQGQTLFIPSGWIYATLTPVDCLAFAGHFLHSLSVEMQMRAYEVERRLKLGSLTQFPNFETACWYMGKHLLEAFKGSHKSGKQLPPHLVQGAKILNGAFRSWTKKQALAEHEDELPEHFRPSQLIKDLAKEIRLSENASKTVRPEVNAAASSDEVCDGDREKEEPPSPVETTPPRSLLEKVSKKKTSKTVKMPKPSKIPKPPKSPKPPKTLKLKDGSKKKGKKCKESASPTIPNLDLLEAHTKEALTKMEPPKKGKTPKSVLSVPNKDTVHTQNDMERLEIREQTKSKSEAKWKYKNSKPDSLLKMEEEQRLEKSPLAGNKDKFSFSFSNRKLLGSKALRPPSSPGVFGALQSFKEDKAKPVRDEYEYVSDDGELKIDEFPIRRKKSAPKRDLSFLLDKKEALLMPTSKPKLDSAVYKSDDSSDEGSLHIDTDTKPGRNAKVKKESGSSAAGILDLLQASEEVGALEYNPNSQPPASPSTQEAIQGMLSMANLQASDSCLQTTWGTGQAKGGSLAAHGARKIGGGNKGTGKRLLKRTAKNSVDLEDYEEQDHLDACFKDSDYVYPSLESDEDNPVFKSRSKKRKGSDDAPYSPTARVGPSVPRQDRPVREGTRVASIETGLAAAAAKLSQQEEQKNRKKKNTKRKPAPNTASPSISTSASASTGTTSASTTPASTTPASTTPASTTPASTSTASSQASQEGSSPEPPPESHSSSLADHEYTAAGTFSGSQAGRASQPMAPGVFLTQRRPSASSPNNTAAKGKRTKKGMATAKQRLGKILKIHRNGKLLL

phf2

Lysine-specific demethylase phf2

1081 amino acids

Lysine demethylase that demethylates both histones and non-histone proteins. Mediates demethylation of dimethylated 'Lys-9' of histone H3 (H3K9me2). Recruited to trimethylated 'Lys-4' of histone H3 (H3K4me3) at rDNA promoters and promotes expression of rDNA (By similarity).

Belongs to the JHDM1 histone demethylase family. JHDM1D subfamily.

120.753 kDa

MATVPVYCICRLPYDVTQFMIECDACKDWFHGSCVGVDEDDAPDIDIYHCPNCEKTHGKSTLKKKKNWSKHDTGQSTDIKAVQNGSQVFIKELRSRTFPSADDVVVKLSGSQLTMDYLEENGFNEPILAQKKDGLGLSMPAPTFYISDVENYVGPDVGVDVVDVTKQTDSKMKLKEFVDYYYSTNRKKVLNVINLEFSDTRMNSIVESPQIVRRLSWVENYWPDDALLGKPKVTKYCLICVKDSYTDFHIECGGASVWYHVLKGEKIFFLIKPTSANLSLYERWRSSSNHSEMFFADQVDKCYKCTLKQGQTLFIPSGWINAILTPVDCLAFSGHFVHNLSVEMQMRAYEIEKRLKVKTLTPFPNFETACWYVGRHLLERFKGLHKANKQPAPYLIHGAKIINGAFRAWTKKQALLEHEDELPENMKPSQLIKDLAKEIRLSENATKAIKSEPSIKVPVEEPPSTHSEPEEPVSPAHVPSPSREKARKKASKPPKPPKPPKPPKMPKAPKPPKVPKVKEGGKKKAKKVKESSPPPKPSSFAALESHAKDILSKMDQPKKTKAVKNVLSMSEKEISKQNNLEKFEIREQNKNKTEAKWKYKNSKPDSLLKMEEECKFDRTLLSGNKDKFSFTMSHKKMLGSKTLKPQTNSSVFGSLQNLKEDKTKPVRDEYEYVSDEGELKIDEFPIRRKKNTVKRDQSFLSDIREPIQPAKKPKFQPLVTKNVDSSDEETLHIDTEAKPEVKSRNSKVKKKGGSAAGILDLLQASKQVGGIDYSTNSQPPASPSTQEAIQGMLSMANLSSSDSLQQPWSNSQSKNNSQSKSNSHGAQGGKKGSGGGGNNSKRPTKRLPKKPRKSSSIESLDYDDDQDHMDACFKDSDYVYPSLESEEDNPVFKSRSKKRKSSDDTPYSPTARVGPSVPRQERPARDGARVASIETGLAAAAAKLSHQEEQQKTKKKKKSTKKKAIVIEEPPKISQDSSSPEHNLDSQDGSLTDHEFNTGTVKSPGGPQPMAPGVFLSQRRPSMSSPNNSTNSTSTNSSSMAKGDRVGSADAKAKRLKKGMATAKQRLGKILKIHRNGKLLL

phf2

Lysine-specific demethylase phf2

1063 amino acids

Lysine demethylase that demethylates both histones and non-histone proteins. Mediates demethylation of dimethylated 'Lys-9' of histone H3 (H3K9me2). Recruited to trimethylated 'Lys-4' of histone H3 (H3K4me3) at rDNA promoters and promotes expression of rDNA (By similarity).

Belongs to the JHDM1 histone demethylase family. JHDM1D subfamily.

118.582 kDa

MATVPVYCICRLPYDVTQFMIECDACKDWFHGSCVGVDEDEAPDIDIYHCPNCEKTHGKSTLKKKKSWNKHDTGQSGDVRPVQNGSQVFIKELRSRTFPSSEDVVVKLSGSQLTLEYLEENGFNEPILIQKKDGLGMAMPAPTFYVSDVENYVGPDVLVDVVDVTKQTDSKMKLKEFVDYYYSTNRKKVLNVINLEFSDARMANIVESPQIVRKLSWVENYWPDDALLGKPKVSKYCLICVKDSYTDFHIECGGASVWYHVLKGEKIFFLIKPTSANLSLYERWRSSSNHSEMFFADQVDKCYKCTLKQGQTLFIPSGWINAILTPVDCLAFSGHFVHSLSVEMQMRAYEVEKRLKVASLTPFSNFETACWYVGKYYLEQFKGLHKANKQPPPYLVHGAKIVNGAFRSWTKKQALLEHEDELPENMKPAQLIKDLAKEIRIAEVKQVVSDSQNATKAIKSEPSNSKPPAEEPPSALSEPEEPMSPAHVSSPSGDKPARKKVPKPPKMPKAPKPPKEPKIKEGGKKKAKKVKEGVIPEKKPSSLAALESHAKDILNKMDQPKKLIKTGMSIMEKETNKPNDVKKFEMIREHNKNKTESKWKYKNSKPDSLLKMEEEHKFDKSLLSHKDNKFAFSLSNKKLLGSKMLKTQTNSSVFGSIQNIKEEKPKPVRDEYEYVSDEGELKIEEFPIRRKKNAVKREFSFLSNIKEPIQPSKKPKLPPSDMKSPDTSDEESLHIDTEAKTDVKGRNSKVSKKKGGSSAGILDLLQASKQVGGIDYSNNSQPPASPSTQEAIQGMLSMANLQSSDSCLQPFWSNSQAKNNSHSSAASKKPSGAAGAGGNSKRPAKRLPKKTQKSSSVDSSDMFDDDQDHLEACFKDSDYVYPSLESEEDNPIFKSRSKKRKNTDDTPYSPTARVGPTVPRQERPAREGARVASIETGLAAAAAKLSHQEEQKIKKKKKSAKKKPIVAEESHKLSHDSSSPEPTPDSESNMADHEYSTGTGKSAGGSQPMAPGVFLSHRRPSSSSSSQNASSVLPAKRLKKGMATAKQRLGKILKIHRNGKLLL

phf2

SWM histone demethylase complex subunit phf2

538 amino acids

Component of the SWM histone demethylase complex that specifically demethylates H3K9me2, a specific tag for epigenetic transcriptional activation, thereby acting as a corepressor. Has a role in regulating heterochromatin propagation and euchromatic transcription.

60.696 kDa

MPNSSYYDDDGGSFEAASYPFQFDGSRRFPNDLHPTMFEGEESNQNGGSVLIDQAFQDIQNPNVNSNMHLENQFQHFHEPNKESGAFGSYKNDDVAKEIESSKNQETDAKSEQAPFTEDASSSNYAHHRSADSQTKSALPPNVPASSSPLPPMSIAMNIARKRSWPASLAIERDNTADALFSTEDGREEQFNLEGVKTKSGRKVHRPNHFDPLVKLPTRRRGPGRRPVVALAMKCSVCQRLQSPPKNRIVFCDGCNTPFHQLCHEPYISDELLDSPNGEWFCDDCIRRKKQAPLVTGTTARELNLSSEEKKSYLLSLPISQLVDILLFCEQLHPDIPFYSPKTSTIVQELQSKRSAFTATMNEPVTGDQYLSLNNGTESQSKTTKHSTSLPSTEPVEVDKQYMESEKIPTIDEYLQEYSNEDEIVLQVLESFPAAVSFSTITNTIQAKYSNRKIKNSNITRSLNRLVRKNRVLRDARGSSYELNRTFDADRPSVRPDISITGPIPIDWMLYTPHTEDLTENFCTYYMFDETPIVLSSI