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pfn-1

Gene
pfn-1
Protein
Profilin-1
Organism
Caenorhabditis elegans
Length
132 amino acids
Function
Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG. Also binds to poly(L-proline) and phosphatidylinositol 4,5-bisphosphate micelles.
Similarity
Belongs to the profilin family.
Mass
14.255 kDa
Sequence
MSGWNAYIDTMTAAAPSIKRCAIVGAADGSVWARTEADNVFKASEEELKTFVALFNDVTQVPAKGADIEGVHYVVPRTEESLIFGKKENTGFFAVKTKSAVLIAVYEGPNEVAAQVRKAVESMQTYLNNAGY