PDH1

Pleiotropic ABC efflux transporter of multiple drugs PDH1

1542 amino acids

Pleiotropic ABC efflux transporter that confers resistance to structurally and functionally unrelated compounds including caspofungin or azoles such as fluconazole, itraconazole, posaconazole, voriconazole, and isavuconazole (PubMed:11257032, PubMed:12244114, PubMed:12557277, PubMed:15105134, PubMed:15388433, PubMed:16803598, PubMed:17581937, PubMed:20038613, PubMed:24273749, PubMed:24838041, PubMed:26482310, PubMed:27486188, PubMed:29371812). Does not play a role in the azole resistance in mature biofilms (PubMed:18651314).

Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily.

175.026 kDa

MNTPDDSSVSSVDSHQPYMGFDDNVEKRIRELARSLTQQSLTSSNRSVNKEAPADGSAPLDRVSTRASSIFSADFKGVNPVFSDEEEDDYDARLDPNSDEFSSKAWVQNMAKITTGDPEFYKPYSIGCCWKDLSASGESADVSYQSTFLNLPVKLLNAVWRKARPARESDTFRILKPMDGLLKPGELLVVLGRPGSGCTTLLKSISSTTHGFQISKDSVISYNGLTPNEIKKHYRGEVVYNAEADIHLPHLTVYQTLVTVARLKTPQNRVKGVTREDFANHVTDVAMATYGLSHTRDTKVGNDLVRGVSGGERKRVSIAEVWICGSKFQCWDNATRGLDSATALEFVRALKTQAHIAKNVATVAIYQCSQDAYNLFNKVSVLYEGYQIYFGDAQHAKVYFQKMGYFCPKRQTIPDFLTSITSPAERRINKEYLDKGIKVPQTPLDMVEYWHNSEEYKQLREEIDETLAHQSEDDKEEIKEAHIAKQSKRARPSSPYVVSYMMQVKYILIRNFWRIKNSASVTLFQVFGNSAMAFILGSMFYKIQKGSSADTFYFRGAAMFFAILFNAFSSLLEIFSLYEARPITEKHRTYSLYHPSADAFASVISEIPPKIVTAILFNIIFYFLVNFRRDAGRFFFYFLINVIAVFAMSHLFRCVGSLTKTLQEAMVPASMLLLALSMYTGFAIPRTKMLGWSKWIWYINPLAYLFESLMVNEFHDRRFPCNTYIPRGGAYNDVTGTERVCASVGARPGNDYVLGDDFLKESYDYENKHKWRGFGVGMAYVIFFFFVYLILCEFNEGAKQKGEMLVFPHSVVKRMKKEGKIRDKTKMHTDKNDIENNSESITSNATNEKNMLQDTYDENADSESITSGSRGGSPQVGLSKSEAIFHWQNLCYDVPIKTEVRRILNNVDGWVKPGTLTALMGASGAGKTTLLDCLAERTTMGVITGDVMVNGRPRDTSFSRSIGYCQQQDLHLKTATVRESLRFSAYLRQPSSVSIEEKNEYVEAVIKILEMETYADAVVGVPGEGLNVEQRKRLTIGVELAAKPKLLVFLDEPTSGLDSQTAWATCQLMKKLANHGQAILCTIHQPSAMLMQEFDRLLFLQKGGQTVYFGDLGKGCKTMIKYFEDHGAHKCPPDANPAEWMLEVVGAAPGSHANQDYHEVWRNSEQFKQVKQELEQMEKELSQKELDNDEDANKEFATSLWYQFQLVCVRLFQQYWRTPDYLWSKYILTIFNQLFIGFTFFKADHTLQGLQNQMLSIFMYTVIFNPLLQQYLPTFVQQRDLYEARERPSRTFSWKAFILAQIVVEVPWNIVAGTLAYCIYYYSVGFYANASQAHQLHERGALFWLFSIAFYVYVGSLGLFVISFNEVAETAAHIGSLMFTMALSFCGVMATPDAMPRFWIFMYRVSPLTYLIDALLSTGVANVDIRCSNTELVTFTPPQGLTCGQYMTPYLNVAGTGYLTDPSATDECHFCQFSYTNDFLATVSSKYYRRWRNYGIFICFIVFDYVAGIFLYWLARVPKTNGKIAKNGKTAKVNFIRRLIPF

pdh1

Pyranose dehydrogenase 1

602 amino acids

Catalyzes the single-oxidation or sequential double oxidation reaction of carbohydrates primarily at carbon-2 and/or carbon-3 with the concomitant reduction of the flavin. The enzyme exhibits a broad sugar substrate specificity, oxidizing different aldopyranoses to the corresponding C-1, C-2, C-3 or C-1,2, C-2,3 and C-3,4 (di)dehydro sugars with substrate-specific regioselectivity. Accepts only a narrow range of electron acceptors such as substituted benzoquinones and complexed metal ions and reacts extremely slowly with O(2) as acceptor. May play a role in the natural recycling of plant matter by oxidizing all major monosaccharides in lignocellulose and by reducing quinone compounds or reactive radical species generated during lignin depolymerization.

Belongs to the GMC oxidoreductase family.

64.684 kDa

MLPRVTKLNSRLLSLALLGIQIARGAITYQHPDDLPSGVDYDFIVAGGGTAGLVVASRLSENSNWKVLVIEAGPSNKDAFVTRVPGLASTLGAGSPIDWNYTTIPQDGLDGRSLDYPRAKILGGCSTHNGMVYTRGSKDDWNSWAGIIGDQGLGWDSILPAIKKAEKFTQDFTDQSVKGHIDPSVHGFDGKLSVSAAYSNISFNDLLFETTKELNAEFPFKLDMNDGKPIGLGWTQYTIDNHAERSSSATSYLESTGDNVHVLVNTLVTRVLSASGNGTDFRKVEFAVDANSPKKQLEAKKEVIVAGGVIASPQILMNSGIGERKVLQAVGIDTLIDNPSVGKNLSDQGATSVMFDTTLPSTDFDVDAALTEWTNSHTGPLARGARLNHLTFVRLPDDKLNGQDPSSGKNSPHIEFQFAQITPQVPTLGVPKQAPLPAANSYRLLLQLAVVNLYSISRGSISLSDNNPFTYPLIDLNMFKEDIDIAILREGIRSAGRMFSSKAFKNSVNKFVYPPADATSDEDLDAFLRSSTFSYVHGVGTLSMSPKGASWGVVNPDFKVKGTSGLRVVDASVIPHAPAAHTQLPVYAFAEYASALIAKSYN

pdh1

Pyranose dehydrogenase

600 amino acids

Catalyzes the single-oxidation or sequential double oxidation reaction of carbohydrates primarily at carbon-2 and/or carbon-3 with the concomitant reduction of the flavin. The enzyme exhibits a broad sugar substrate specificity, oxidizing different aldopyranoses to the corresponding C-1, C-2, C-3 or C-1,2, C-2,3 and C-3,4 (di)dehydro sugars with substrate-specific regioselectivity. Accepts only a narrow range of electron acceptors such as substituted benzoquinones and complexed metal ions and reacts extremely slowly with O(2) as acceptor. May play a role in the natural recycling of plant matter by oxidizing all major monosaccharides in lignocellulose and by reducing quinone compounds or reactive radical species generated during lignin depolymerization.

Belongs to the GMC oxidoreductase family.

65.092 kDa

MFPRVVRLNSRLVSFALLGLQIANGAITYQHPDDLPSNVNYDFIVAGGGTAGLVVASRLSENSDWNILVIEAGPSNKDTPETRVPGLADSLPGSRTDWNYTTIPQDALGGRSLNYSRAKVLGGCSTHNGMVYTRGSEDDWNYWAEVTGDQALSWDSVLPIMKKAEKFSQDFSDQSVDGHIDPAVHGRDGLLSVVASYTNVSFNDLLLQTTKELSDEFPFKLDLNDGKPHELAWTQYTIDHNAERSSSATSYLETTGDNVHVLVNTHVTRIVSAGNGTNFRSVEFAVDSNSPKKVLQAKKELILSAGVIASPQVLMNSGIGGREELQAIGVDTLIDNPSVGKNLSDQAATLLMFDTTLPNTDYDVAAALTEWDKSRSGPMAHGARLNHLTWVRLPDDKLNGSDPSSGKDSPHIEFQFRQISHQLPPADVPNQVQLPDPDSIGVVLQFSVVNLYSISPGSVILNDNDPFANPMIDLNMFGDQKDIAILREGVRSARRMFSSPAFKDVINGTVYPPADVTSDEDLDAFLRTSAESYWHGVGTLSMSPQNASWGVVNPDFRVKGTSGLRVVDASVIPRAPAGHTQVPVYTFAEHASVLIAASYH

pdh1

Pyranose dehydrogenase

595 amino acids

Catalyzes the single-oxidation or sequential double oxidation reaction of carbohydrates primarily at carbon-2 and/or carbon-3 with the concomitant reduction of the flavin. The enzyme exhibits a broad sugar substrate specificity, oxidizing different aldopyranoses to the corresponding C-1, C-2, C-3 or C-1,2, C-2,3 and C-3,4 (di)dehydro sugars with substrate-specific regioselectivity. Accepts only a narrow range of electron acceptors such as substituted benzoquinones and complexed metal ions and reacts extremely slowly with O(2) as acceptor. May play a role in the natural recycling of plant matter by oxidizing all major monosaccharides in lignocellulose and by reducing quinone compounds or reactive radical species generated during lignin depolymerization.

Belongs to the GMC oxidoreductase family.

64.241 kDa

MARFNARLFSIAILGFQVARSAITYQHPDDLPGDVDYDFIVAGGGTAGLVVASRLGENSKWNVLVIEAGPSNKDVFATRVPGLAETLPTSHIDWNYTTVPQQALGGRSLNYSRAMILGGCSTHNGMVYTRGSKDDWNKWADVTGNRDLSWDSILPIMKKVEKFSEDFSDQSVEGHIDPSVHGNDGKLSVVASYTNVSFNDLLLETTKELVDEFPFKLDMNDGNPVGLTWNQYTIDHNAERSSSATAYLESTGDNVHVLLNTRVTRIVPTGKTNFRTVEFAVDAGGPRKQLTAKKEVILSGGFIASPQILMNSGIGDQEALKAVGVDTLVNNPSVGKNVSDQAATLVLFDTTLPNTDFDVDAAIVEWNNSHAGPLATGAPLNHLIWVRLSDDKLSGSDPSSGKDSPHIEFQFSKISHRIPPANVPNQVALPSQDSIGVVIQFSVVNLNSISRGSVSLNDNNPFSHPLIDLNMLGEEQDIAILREGVHSARRMLSSEAFKPFVNGSVHPPANITSDEDLDAFLHTTTKSYLHGVGTLSMSPQNASWGVVDPDFRVKGTTGLRVVDASVIPSVPAGHTQTPVYAFAEYASIVIAKSYN

pdh1

Pyranose dehydrogenase

594 amino acids

Catalyzes the single-oxidation or sequential double oxidation reaction of carbohydrates primarily at carbon-2 and/or carbon-3 with the concomitant reduction of the flavin. The enzyme exhibits a broad sugar substrate specificity, oxidizing different aldopyranoses to the corresponding C-1, C-2, C-3 or C-1,2, C-2,3 and C-3,4 (di)dehydro sugars with substrate-specific regioselectivity. Accepts only a narrow range of electron acceptors such as substituted benzoquinones and complexed metal ions and reacts extremely slowly with O(2) as acceptor. May play a role in the natural recycling of plant matter by oxidizing all major monosaccharides in lignocellulose and by reducing quinone compounds or reactive radical species generated during lignin depolymerization.

Belongs to the GMC oxidoreductase family.

64.527 kDa

MIPRVAKFNFRLLSLALLGIQVARSAITYQNPTDLPGDVDYDFIVAGGGTAGLVVASRLSENPEWNVLVIEAGPSNKDVFETRVPGLSSELRPRFDWNYTTIPQDALGGRSLNYSRAKLLGGCSSHNGMVYTRCSRDDWDNYAEITGNQAFSWDSILPVMKRAEKFSKDSSHKPVKGHIDPSVHGGDGKLSVVASYTNASFNDLLLETAKELSGEFPFKLDMNDGRPLGLTWTQYTIDQRGERSSSATAYLEGTGNNVHVLVNTLVTRIVSAENGTDFRSVEFATDADSPKIQLRAKKEVIVSGGVINSPQILMNSGIGGREVLGANGIDTLVDNPSVGKNLSDQAATIIMLDTTLPITDYDVDAALIEWKKSHTGPLAQGGRLNHLTWVRLPDDKLDGLDPSSGENSPHIEFQFGQISHQLPPSGLTRFSFYRHCSPIPPLINLYTVSRGSISLSNNDPFSHPLIDLNMFGEEIDPAILREGIRSARRMLSSQAFKGFVGETVFPPSDATSDEDLDTFLKTSTFSYVHGVGTLSMSPQSASWGVVNPDFRVKGTSGLRVVDASVIPFAPAGHTQEPVYAFAEHASVLIAKSYS

PDH1

2-methylcitrate dehydratase, mitochondrial

520 amino acids

Component of the methylcitrate cycle that catalyzes the dehydration of 2-methylcitrate to 2-methyl-cis-aconitate. The methylcitrate cycle is a metabolic pathway for the consumption of propionic acid.

Belongs to the PrpD family.

57.737 kDa

MRAFRSAANFGAASNIYRKSFTPASIASNRFVSARMSSIMTDNARPNTDKVVQDIADYIHDYKIDSSVAMETARLCFLDTLGCGLEGLKYQQCANIVGPVVPGTIVPNGTKVPGTDYQVDPVRGAFNIGTIIRWLDFNDCWLAAEWGHPSDNLGGILAVADWQTRSAKAGLEGKVFKVKDVLEGMIKAHEIQGGLAIENSFNRVGLDHVVLVKIASTAVVSGMLGLSREQTADAISQAFVDGQSLRTYRHAPNTMSRKSWAAGDATSRAVNLALLVKKGEGGMPSILTAKTWGFYDVLFGGKEFKFQRPYGSYVMENVLFKISFPAEFHAQTACESAMLLHEELKKLGKTSDDIASIKIRTQEAAMRIIDKKGPLHNYADRDHCIQYMVAIPLIHGRLTADDYTDEIASDPRIDALREKMECVEDKRFSEEYHAPDKRYIGNAIEITLKDGTVLDEIEVNYPIGHRQRREEGTPVLLEKFARHLRGRFPEGQVEKILAASNQDIVNMDIDEYVDLYVKKD

PDH1

Probable 2-methylcitrate dehydratase

516 amino acids

Catalyzes the stereospecific dehydration of (2S,3S)-2-methylcitrate (2-MC) to yield the cis isomer of 2-methyl-aconitate.

Belongs to the PrpD family.

57.684 kDa

MFLAKNLKNNKIKVCLPKKKFAALSTASIQTNERPNPDKVLKDIAKYVHETPLKSSLALDTARLCFLDTLGCGLAALKFKQAQNIIKPIVPGTIVPSGTKILGTSYVMDPVKGAFAIGTLIRWLDYNDCWLAAEWGHPSDNLGGILAVADHLSRLNKATHGKNGKQFLVKDVLEAMIKAHEIQGIIALENSFNKVGLDHVVLVKVATAGVVSKMLGLSQEQTIEALSQAFVDGQSLRTYRHAPNTGSRKSWAAGDAVSRAVNLAYLVKNANVGTIPSVLTARTWGFYDVLFKGKPFSFQQRSKYDSYVMENVLFKISFPAEFHAQTAVEAAVKAYRILAKQGKTFKDIKSIRIRTQEAAMRIIDKSGPLYNYADRDHCIQYMIAVPLITGNLTATDYSDEVARNPEIDNLRSKMYCIEDTHLTQNYHDPDKRSIGNALLIELNDGTQLDEIFVEYPVGHKFRREEGIPLLMNKFQRHLREHFVESPDKVDLIMKVSSKTNFLNMQIDKYMDLFTEG

pdh1

Protein pdh1

226 amino acids

26.021 kDa

MNHFSKFSVTKRLLILEVLFSAISFGISIYIKVFGRSSIVTFFLLCFHLVPNALFLFPWTIITTSFVDANVFTLLSSILILSVYGVEIERSWGHKEYLLFCQFLTVIPNIAVLIPCFIAYKITDSHYLLVAIIQSTTAIQAGILTAWYQLYSCKKEESSNKFLCPLSKYLIYLFLSIHLFYVFQSFPWTYFCLAVSGTCISELYVLFVHPVVQELFHLESHTQLPI

PDH1

Pigment-dispersing hormone type 1

79 amino acids

The pigment-dispersing hormone causes the migration of the distal retinal pigment into the proximal end of the pigment chromatophore cells and thus decreases the amount of light entering the retinulas. May also function as a neurotransmitter and/or neuromodulator (By similarity).

Belongs to the arthropod PDH family.

8.561 kDa

MRSAVVVALLVMVAMSLQLTAAQEDLKYFEREVVAELAAQILRVAQGPSAFVAGPHKRNSELINSLLGIPKVMNDAGRR

PDH1

Pigment-dispersing hormone 1 peptides

78 amino acids

The pigment-dispersing hormone causes the migration of the distal retinal pigment into the proximal end of the pigment chromatophore cells and thus decreases the amount of light entering the retinulas. May also function as a neurotransmitter and/or neuromodulator (By similarity).

Belongs to the arthropod PDH family.

8.539 kDa

MRSSVIVAVLVVVALAALLTQGQELKYQEREMVAELAQQIYRVAQAPWAAAVGPHKRNSELINSILGLPKVMNDAGRR