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paxB

Gene
paxB
Protein
Exotoxin translocation ATP-binding protein PaxB
Organism
Pasteurella aerogenes
Length
711 amino acids
Function
Part of the ABC transporter complex PaxBD involved in PaxA export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (Probable).
Similarity
Belongs to the ABC transporter superfamily. Protein-1 exporter (TC 3.A.1.109) family.
Mass
80.424 kDa
Sequence
MEPLMSFKQKNDYGLHALVILAQYHNIAVSPEEIKHKFDPEGKGIDLVAWLLAAKSFELKAKKVKKSIDRLPFIHLPALIWRDDGQHFILTKIDTQTNRYLIFDLEERNPKVLSAVEFQQVFQGNVILLTSRASIMGKLAKFDFTWFIPAIIKYRKIFVEVMIVSIFLQLFALITPLFFQVVMDKVLVHRGFSTLNVITVALAIVVIFEIVLSGLRTYVFSHSTSRIDVELGAKLFRHLLALPISYFENRRVGDTVARVRELDQIRNFLTGQALTSVLDLLFSFIFFAVMWYYSPKLTIVILLSLPCYIAWSIFISPILRRRLDEKFTRNADNQAFLVESVTAIDTIKALAVTPQMTNIWDKQLASYVSADFRVTVLATIGQQGVQLIQKTVMIINLWLGAHLVISGDLSIGQLIAFNMLSGQVIAPVIRLAQLWQDFQQVGISITRLGDVLNAPTENFQGKLSLPEINGDVTFKNIRFRYKPDAPIILNDVNLTIKQGEVIGIVGRSGSGKSTLTKLLQRFYIPENGQVLIDGHDLALADPNWLRRQIGVVLQDNVLLNRSIRDNIALTDPSMPMEQVIHAAKLAGAHDFISELREGYNTMVGEQGAGLSGGQRQRIAIARALVNNPRILIFDEATSALDYESEHIIMRNMQQICHGRTVIIIAHRLSTVRKADRIIVMEKGHIVERGKHSELLENKDGLYYYLNQLQSI

Gene
paxB
Protein
Paxillin-B
Organism
Dictyostelium discoideum
Length
569 amino acids
Function
Required for cell-substrate adhesion, cell sorting, slug migration, and cell differentiation. May function upstream of limB.
Similarity
Belongs to the paxillin family.
Mass
62.33 kDa
Sequence
MATKGLNMDDLDLLLADLGRPKSSIKVTATVQTTATPSSGKNFDNSDIQNEIQSIIEELDQQPQTVQTISTPAPKNHNTTTTTASFSVSSQPAPQPPQQSQQIDGLDDLDELMESLNTSISTALKAVPTTPEEHITHANSNSPPPSLHKNTSSTNSASSLSRPNNNPSVVSTPQPGKVTSTATITTKKQPALSKATLETTSGNNVYSSQPSQSQPQPYKVTATNSQPSSDDLDELLKGLSPSTTTTTTVPPPVQRDQHQHHHQHQHHHHHNPNHNQTQTVTTQINIGRTNTPNNNNNNNTNSPKVVHGDDLDNLLNNLTSQVKDIDSTGPTSRGTCGGCRKPIFGETIQAMGKFYHPEHFCCHNCQNPLGTKNYYEQESLPHCEKCYQELFCARCAHCDEPISDRCITALGKKWHVHHFVCTQCLKPFEGGNFFERDGRPYCEADFYSTFAVRCGGCNSPIRGECINALGTQWHPEHFVCQYCQKSFTNGQFFEFGGKPYCDVHYHQQAGSVCSGCGKAVSGRCVDALDKKWHPEHFVCAFCMNPLAGGSYTANNGKPYCKGCHNKLFA

Gene
paxB
Protein
Terpene cyclase paxB
Organism
Penicillium paxilli
Length
243 amino acids
Function
Terpene cyclase; part of the ATM2 gene cluster that mediates the biosynthesis of paxilline, a mycotoxin that acts as an inhibitor of mammalian maxi-K channels (PubMed:11169115, PubMed:23949005, PubMed:16494875). PaxG, the geranylgeranyl diphosphate (GGPP) synthase is proposed to catalyze the first step in paxilline biosynthesis (PubMed:23949005, PubMed:16494875). Condensation of indole-3-glycerol phosphate with GGPP by paxC then forms 3-geranylgeranylindole (3-GGI), followed by epoxidation and cyclization of this intermediate (by paxM and paxB) to form paspaline (PubMed:23949005, PubMed:16494875). Paspaline is subsequently converted to 13-desoxypaxilline by paxP, the latter being then converted to paxilline by paxQ (PubMed:23949005). Finally paxilline can be mono- and di-prenylated by paxD (PubMed:23949005).
Similarity
Belongs to the paxB family.
Mass
26.917 kDa
Sequence
MDGFDVSQAPPEYQAIKPLADLFVVGMGVGWIINYIGMVYISFKHETYGMSIMPLCCNIAWELVYCLVFPSKSPVERGVFWMGLLINFGVMYAAITFSSREWGHAPLVERNISLIFFVATMGFLSGHVALALEIGPALAYSWGAVICQLLLSVGGLSQLLCRGSTRGASYTLWASRFLGSTCTVGFAGLRWMYWSEAFGWLNSPLVLWSLVVFLSIDGFYGICFWYVDRNEKSLGISGPKKAN