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paxA

Gene
paxA
Protein
Exotoxin PaxA
Organism
Pasteurella aerogenes
Length
1049 amino acids
Function
PaxA is associated with abortion cases in swine and septicemia in young piglets. Shows cohemolytic activity with the sphingomyelinase of S.aureus but is devoid of direct hemolytic activity.
Similarity
Belongs to the RTX prokaryotic toxin (TC 1.C.11) family.
Mass
112.309 kDa
Sequence
MSTWSSMLADLRKQAEIAKQQAKKGIDVTKNGLQYGVSQVKLQALAAGKSIQKYGNKLVLVIPKDYDVNTGNGFFDLAKAAEELGIQVKYIDRNDLEIAHKSLGVTDQFLGLTERGLTLFAPQLDKFLQQHSKISNVVGSSTGDTVNKLAKSQAIISGVQSVLGSVLAGINLNEAIISGGSELELAKAGVDLASELVGNIAKGTATIEAFSEQIQNFGKLVQNAKGLGGVGQQLQHISGSALSKTGLGLDIISSLLSGVTASFTLADKNASTSTKVAAGFELSNQVIGGITKAVSSYILAQRLAAGLSTTGPAAALIASSISLAISPLSFLRVADNFNRSKDIREFAERFKKLGYEGDKLLSDFYHEAGTIDASITTISTALSAIAAGTAAASAGALVGAPITLLVTGITGLISGILEFSKQPMLEHVASKLGTKIEEWERKYGKNYFENGYDARHKAFLEDSLSLLSSFNKQYETERAVLITQQRWDEYIGELAGVTGKGDKISSGKAYVDYFEEGKLLAKKPDDFNRVILDPKKGKIDISNSQTSTLLKFVTPLLTPGTESRKRTQTGKYEYVTKLDVNGINQWEVNGVKEKGAVYDFTNLIQHVHISSSVARGEEYREVRLVSRLGKGNDKVFLASGSAEIHAGDGHDVVYYDKTDTGLLMVDGTQATKQGDYTVTRELSGATQILREVVKNQKSSVGSRQETVEYRDNELAQSGNSNLKAKDNLYSVEEIIGSNHRDEFKGSKFRDIFHGADGDDLLNGNDGDDILYGDKGNDELRGDNGNDQLYGGEGNDKLFGGNGNNYLSGGDGDDELQVLGNGFNVLRGGKGNDKLYGGAGSDFLDGGEGDDYLAGGEGNDFYVYRSTSGNHTIYDQGKSSDSDTLYLSDLTFDRLLVEKVDNNLVFKPSDHNSNRGSLTIKDWFKTGHGYNHKLEQIVDKNGRKLTSDNLETHFNGTPKTNLLGYTAENQNESNLSSLKTELGKIISSAGNFGLAKQGNNNHSAALNNDVDKLISSASSFATAQMGGSGIGLLPSNNANSTILSGLARTA

Gene
paxA
Protein
Paxilline synthesis protein A
Organism
Penicillium paxilli
Length
356 amino acids
Function
Paxilline synthesis protein A: Part of the gene cluster that mediates the biosynthesis of paxilline, a mycotoxin that acts as an inhibitor of mammalian maxi-K channels (PubMed:11169115, PubMed:23949005). PaxG, the geranylgeranyl diphosphate (GGPP) synthase is proposed to catalyze the first step in paxilline biosynthesis (PubMed:23949005). Condensation of indole-3-glycerol phosphate with GGPP by paxC then forms 3-geranylgeranylindole (3-GGI), followed by epoxidation and cyclization of this intermediate (by paxM and paxB) to form paspaline (PubMed:23949005). Paspaline is subsequently converted to 13-desoxypaxilline by paxP, the latter being then converted to paxilline by paxQ (PubMed:23949005). Finally paxilline can be mono- and di-prenylated by paxD (PubMed:23949005). The exact role of paxA in paxilline biosynthesis is still unknown (PubMed:23949005).
Similarity
Belongs to the paxA family.
Mass
39.816 kDa
Sequence
MTSITTSVLVLHSLLAANFKYYQSFQNGFIDMLSAMADSNSVSGLPGQLCREYTGIRPLDTFLTSCTVFFWPTFQGEIPGLSLYGIAFASAMIPMWLIIVIDVHRRRQPFGALVELIAFAGPLIQCIGPGLVMPLLLARIHTPSRDSKSASQFDYRTFIPSMIIGYILPLLLASLPAPLILSYHNKQQFIAIWQGWPLYSSVLMWAFRRRSGHVHCSRHKGLKHACIFALACSSAGHLVLLSLTWLWSLSYWGYIQSAPWNEPPLASLEAGVLRFLQWDYTLSASATLSWAIAFRHEVVQQKSLRISLLSLLRCLIGIVFLGPCSMVALLYWQTCSLQEEAGQKAPAKDKQLDQEI