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patB

Gene
patB
Protein
Probable plasma membrane ATPase
Organism
Dictyostelium discoideum
Length
1058 amino acids
Function
The plasma membrane ATPase is a hydrogen ion pump. The proton gradient it generates drives the active transport of nutrients by H(+) symport. The resulting external acidification and/or internal alkinization may mediate growth responses.
Similarity
Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIIA subfamily.
Mass
117.268 kDa
Sequence
MDNNQIPKNSPESSAINSAESSPKSNVSSDVLHENHHKEQQQLQQQLQQEQQQQQLPTTPQSEPTQRVNNNEEGIEMDRIAENSNINVPSDVGESSLKTISGYPSSKNTEAGSSSSGKKEEDYNYRSTWVPKLHQELFENPEVLESRRTKQRASNYRKTLEREKEGIKPLDNILEELKANANGLTKAEAQKRLEEVGPNAIPDVKRYPILEFLYFMWNPLSWTMEVAAIVSIALLDWVDFILICALLLLNATIGFIEENTAGNAVEALKNSLVSQIRCMRDGEWVMLPSPDLVPGDVVMLKIGAIIPADCRVIEAEQVKIDQSSLTGESLPVTKKIGDEVYSGSAMKQGEAKCVVTATGVNTFFGRAANLVQETEGHGHLQVILRNIGLFCISFIAIWVLVELLVDFLGYDGYCHGVGGGRCLPLNNALVLLVGGIPIAMPTVLSVTMAIGATQLSKKKAIVSRLASIEELAAMDILCSDKTGTLTLNILTVDEPLPVGDTPKEDIVFHAFLACSEGEDQDAIDKAISNYCRDTYPNVDYSGNEIVKHYPFNPEDKKAMGLVNANGKQFKTAKGAPQIILREADNYKQVGEAVEKEIENLADRGYRALGVSVSYDAPDFKVWHFEGLIPLFDPPRHDTEDTIKRALEMGVSVKMITGDQLAIAKETARRLGMGGNLFTIPYLENNDLGISEGEVIEMADGFAEMWPEHKYKVVDQLQKRKHVVGMTGDGVNDAPALKKAQIGIAVAGATDAARSVSDIVLTSSGLSVIIDAIISSRKIFQRMRNYVIYSVAATVRICTTFGILTVAWNFKFPTIATVIIAILNDGTMLTISKDRVRARNEPDQWNLFEVFTMALCYGFYLVGSTIVFFAIIHDGTWFHDAINLRILTDNELRGLIYLQVSISGLATIFVSRSQGFSYFERPGNLVIFAFVMSQIVATFIGVYGFRGYPHDSFSDNPDYPVHGTNFQGCGWGWAVCAWIWCFLWYIPMDFIKLGVTYILRGKIEPINKDALRKIYGWFGKEIPKEATQVSHKVAEQQAKRDALHAQETHHKSVVTDNKV

Gene
patB
Protein
Carboxylesterase patB
Organism
Penicillium expansum
Length
561 amino acids
Function
Carboxylesterase; part of the gene cluster that mediates the biosynthesis of patulin, an acetate-derived tetraketide mycotoxin produced by several fungal species that shows antimicrobial properties against several bacteria (PubMed:25120234, PubMed:30100914). The pathway begins with the synthesis of 6-methylsalicylic acid by the polyketide synthase (PKS) patK via condensation of acetate and malonate units. PatG then catalyzes the decarboxylation of 6-methylsalicylic acid to yield m-cresol. The cytochrome P450 monooxygenase patH then converts m-cresol to m-hydroxybenzyl alcohol, which is further converted to gentisyl alcohol by the cytochrome P450 monooxygenase patI. The conversion of gentisyl alcohol to two-ring compound neopatulin remains a matter of speculation, but it involves at least two intermediates, isoepoxydon and phyllostin. PatN catalyzes the transformation of isoepoxydon into phyllostin. The last part of the biosynthetic pathway involves the conversion of neopatulin to ascladiol followed by the transformation of the latter into patulin (By similarity).
Similarity
Belongs to the type-B carboxylesterase/lipase family.
Mass
61.487 kDa
Sequence
MQIINWASLLLVTWETVVAAELPIVDLGYQRHQAIGFNSTGRYYQFSNVRYAEPPLGPLRFSLPVSPRNRSHEVVNGKGLGNICPQSQACWFNVQGDFVSAVTAGSTFNFTAAYDQVYQQDECTKPRPVADQNPLESEDCLFLDVYVPEKVISKRRDGNGKSNPGAPVLVYFQDGAYVSGSKSDQNPSGLIATSREDGSTGIIYVGVNYRLGVFGWLSGQKFQSEGGLPNAGLYDERLALEWVQRHITKFGGDPSRVTVMGVSAGGGSITMQLTAYGRAIRPPFAQIIAQSPAWEPGTKTPAIEDDLLDSFLTLLNVSSLEEARRLPSQALLDANYELVASRPYGSGVFGPAIDGSFVPDSPKRLLLERKVDPSVRILTSYTANEGFMLAPANVTDDATFNRYVDVLLRGANASVRAHTSRVLYPPIFNGSWPYHSQHERANLLWSEVSTTCNTRYLHQAVATPGYAIEYAVKPAMHLSDTSSVFYNGQGSSSSLNATIAQLMQRQIVQFVKTGNPNVKGDPHVPLYHGQAHVLSLGDNGVRVEPALTNTDRCTYWQQVEF

Gene
patB
Protein
Carboxylesterase patB
Organism
Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1)
Length
555 amino acids
Function
Carboxylesterase; part of the gene cluster that mediates the biosynthesis of patulin, an acetate-derived tetraketide mycotoxin produced by several fungal species that shows antimicrobial properties against several bacteria (PubMed:19383676, PubMed:24334092). The pathway begins with the synthesis of 6-methylsalicylic acid by the polyketide synthase (PKS) patK via condensation of acetate and malonate units (PubMed:19383676). PatG then catalyzes the decarboxylation of 6-methylsalicylic acid to yield m-cresol (PubMed:24334092). The cytochrome P450 monooxygenase patH then converts m-cresol to m-hydroxybenzyl alcohol, which is further converted to gentisyl alcohol by the cytochrome P450 monooxygenase patI (PubMed:19383676). The conversion of gentisyl alcohol to two-ring compound neopatulin remains a matter of speculation, but it involves at least two intermediates, isoepoxydon and phyllostin (PubMed:19383676). PatN catalyzes the transformation of isoepoxydon into phyllostin (PubMed:19383676). The last part of the biosynthetic pathway involves the conversion of neopatulin to ascladiol followed by the transformation of the latter into patulin (PubMed:19383676).
Similarity
Belongs to the type-B carboxylesterase/lipase family.
Mass
59.936 kDa
Sequence
MLFTASLLLLLPWASAAPANLPIVDLGYQRHQAISFNSTGQYYSFTNIRYAEPPLGSRRFAPPVAPHGRSKNIVNGTGLGYKCPQALACWFNVQNKFTSAAAAGTPFDFNAAYEEVYTKDACTEPAKQDPLQSEDCLFLDVYVPQDVWQKGPQAAHQKGGAPVLVYLQDGAYVGGSKSDQNPAGLIARSREEGSSGMIYVGINYRLGVFGWLSGRKFTSSGGKPNAGLLDQRLALEWIQRHIHLFGGDPSRVTVMGVSAGGGSIIMQMTAYGRGISPPFAQVITQSPAWEPGTKTPAIEDDLFDTFLASLNVTSLDQARRLPSHALTDANYRLVASRPYGAGVLGPAIDGDFIPDSPKRLLLQGKANPGVRVLTSYTAAEGFGIAPANITDEASFQRYVGLMLAGTDASVRTHAATVLYPAVFDGSMPYRTQHDRASLLWADLAASCNTRYLHAAVRTPGYAIEYSVPPALHLSDTPSVFYNGPVADPTVNGTIAELLQRQIVRFVKTGNPNGEPDPEVPVYDGRDLLDLGDDGVLVRPDSTDNARCEYWQKVHF

Gene
patB
Protein
Cystathionine beta-lyase PatB
Organism
Bacillus subtilis (strain 168)
Length
387 amino acids
Function
Catalyzes the transformation of cystathionine to homocysteine. Also exhibits cysteine desulfhydrase activity in vitro, producing sulfide from cysteine.
Similarity
Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. MalY/PatB cystathionine beta-lyase subfamily.
Mass
42.789 kDa
Sequence
MNFDKREERLGTQSVKWDKTGELFGVTDALPMWVADMDFRAPEAITEALKERLDHGIFGYTTPDQKTKDAVCGWMQNRHGWKVNPESITFSPGVVTALSMAVQAFTEPGDQVVVQPPVYTPFYHMVEKNGRHILHNPLLEKDGAYAIDFEDLETKLSDPSVTLFILCNPHNPSGRSWSREDLLKLGELCLEHGVTVVSDEIHSDLMLYGHKHTPFASLSDDFADISVTCAAPSKTFNIAGLQASAIIIPDRLKRAKFSASLQRNGLGGLNAFAVTAIEAAYSKGGPWLDELITYIEKNMNEAEAFLSTELPKVKMMKPDASYLIWLDFSAYGLSDAELQQRMLKKGKVILEPGTKYGPGGEGFMRLNAGCSLATLQDGLRRIKAALS