Protein
Aspartate 1-decarboxylase
Organism
Mycobacterium tuberculosis (strain ATCC 25177 / H37Ra)
Function
Overexpression of wild-type or mutant proteins confers resistance to pyrazinoic acid (POA), the active form of the anti-tuberculosis prodrug pyrazinamide (PZA), when grown on agar plates.
Similarity
Belongs to the PanD family.
Sequence
MLRTMLKSKIHRATVTCADLHYVGSVTIDADLMDAADLLEGEQVTIVDIDNGARLVTYAITGERGSGVIGINGAAAHLVHPGDLVILIAYATMDDARARTYQPRIVFVDAYNKPIDMGHDPAFVPENAGELLDPRLGVG