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orc6

Gene
ORC6
Protein
Origin recognition complex subunit 6
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Length
435 amino acids
Function
Component of the origin recognition complex (ORC) that binds origins of replication. It has a role in both chromosomal replication and mating type transcriptional silencing. Binds to the ARS consensus sequence (ACS) of origins of replication.
Similarity
Belongs to the ORC6 family.
Mass
50.296 kDa
Sequence
MSMQQVQHCVAEVLRLDPQEKPDWSSGYLKKLTNATSILYNTSLNKVMLKQDEEVARCHICAYIASQKMNEKHMPDLCYYIDSIPLEPKKAKHLMNLFRQSLSNSSPMKQFAWTPSPKKNKRSPVKNGGRFTSSDPKELRNQLFGTPTKVRKSQNNDSFVIPELPPMQTNESPSITRRKLAFEEDEDEDEEEPGNDGLSLKSHSNKSITGTRNVDSDEYENHESDPTSEEEPLGVQESRSGRTKQNKAVGKPQSELKTAKALRKRGRIPNSLLVKKYCKMTTEEIIRLCNDFELPREVAYKIVDEYNINASRLVCPWQLVCGLVLNCTFIVFNERRRKDPRIDHFIVSKMCSLMLTSKVDDVIECVKLVKELIIGEKWFRDLQIRYDDFDGIRYDEIIFRKLGSMLQTTNILVTDDQYNIWKKRIEMDLALTEPL

Gene
orc6
Protein
ORC1-type DNA replication protein 6
Organism
Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1)
Length
374 amino acids
Function
Involved in regulation of DNA replication.
Similarity
Belongs to the CDC6/cdc18 family.
Mass
41.72 kDa
Sequence
MDEDPEEGLLGWGETVFRDEHVFEIDYVPEVFRHRESQLQTLQYALRPAVRGSRPLNVVARGPPGTGKTTAVQKLFGELSGQPGVQTVRVNCQVDSTRYAVFSRVFEEIFDYEPPSSGISFKKLFGQVAERIADDDEVLVVALDDVNYLFYEDEAGDTLYSLLRAHETQPGAKVGVVVVSSDLELDVIEALDGRVQSVFRPEEAYFSAYDRAEITDILRDRVEVGFREGAVAEPVLDAVGGRTDEAGDLRVGIDVLRRAGLHAESRASKTVEMEDVDAVYEDAKHVHLSRTLAALSDNERALVRTVAEQEGDRAGDVYDVFNDRTDLGYTRYTEIVNKLDELGVIDAAYEQRSGRGRSRTLRLTHDSEAVLERL

Gene
ORC6
Protein
Origin of replication complex subunit 6
Organism
Oryza sativa subsp. japonica
Length
295 amino acids
Function
Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.
Similarity
Belongs to the ORC6 family.
Mass
32.606 kDa
Sequence
MDMSSIASRLGLSGSRPVVRKAAELRRLCDVTFDSSVLGIGEVCKAIICLEIAASKFQVIFDRAEAVRMSGMSEKAYIRSFNALQNGLGVKTTLDVRELGIQFGCVRLIPFVQKGLSLYKERFLAALPPSRRASTDFGRPVFTAAAFYLCAKRHKLKVDKLKLIDLCGTSSSEFTTVSTSMADLCFDVFGIAKEKKDAKSIKGSRELLDVLPSKRKHDDDSDSSGESSGDDQDELDLPTYKRHKKMEKEAYNDWKSSVLSNKQTKPDPAKPRKQAQLNFKKKPSDMALEVSSAAN

Gene
ORC6
Protein
Origin of replication complex subunit 6
Organism
Arabidopsis thaliana
Length
284 amino acids
Function
Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.
Similarity
Belongs to the ORC6 family.
Mass
31.77 kDa
Sequence
MDISDIGRKLSLDNNKLLIRKAAEIRRLCDAQFDSSIIGVGEICKAVICLEIAATRLQIIFDRQAAVKLSGMSEKAYSRSFNSLQNVIGIKIKLNVRELAVQFGCVRVIKSVQNVLSSYKERFLASLPASRRANADFTRPVFTAAAFYLCAKKQKLKVDKLRLIEVCGTSESEFSCVSTSMTDLCFDCVGISKEKKDAKDVKGNRDLLDVLPGKRRLEDGGYSSGDESSCYKRHKKMEEAKYEDWKSTVVNSIKKNPEKGTKRVIQASLNFPKKSETKELQVDS

Gene
orc6
Protein
Origin recognition complex subunit 6
Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Length
264 amino acids
Function
Component of the origin recognition complex (ORC) that binds origins of replication. It has a role in both chromosomal replication and mating type transcriptional silencing. ORC binds to multiple sites within the ars1 origin of DNA replication in an ATP-independent manner.
Similarity
Belongs to the ORC6 family.
Mass
30.703 kDa
Sequence
MERQQIIESLRRIIPTESTEYNERLISLGESFLEWSKYKHNLKATEELCRPYMAAHLACELLSNDLNLEINLLATPIPKKKYYKLFTYFQEILSPLTKSLAAKDDLMETITYLCTKLGGSTAIPYVKQLVKAVVTNDMRIEHKRGIIIAAYLLVSAKAFGKDELHINHTERRKAQSVLQDTSSALQIQYWMHVLSESWQYKEIPLNGIEGYESQKQRIKPWSGIASMIQIDYEKRLQNYPIWKACIEERIQYYKSQLEKDGTAS

Gene
Orc6
Protein
Origin recognition complex subunit 6
Organism
Mus musculus
Length
262 amino acids
Function
Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication (By similarity).
Similarity
Belongs to the ORC6 family.
Mass
29.188 kDa
Sequence
MESELVRRLAPRLGLAEPSVLRKAEEFLRLSKVKCVSLSARSSETSNAVICLDLAASCRKCPLDRAYLIRLSGLNKMMYQSCLKSFECLLGLNSNVGIRDLAVQFSCTEAVNLAAEILQSYKSGLPETQRADLDLSRPLFTTAALLSACKILKIKVDKTKMITTSGVKKAILDRLCKQLEKIGQQINRDSADLARPALKRKKPEFSPTLKKKEPGLEPPAKEIEVIETLHKLPKDEDLTQDYEEWKRKILENAAKAQTATAE

Gene
Orc6
Protein
Origin recognition complex subunit 6
Organism
Drosophila melanogaster
Length
257 amino acids
Function
Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication (By similarity).
Similarity
Belongs to the ORC6 family.
Mass
29.239 kDa
Sequence
MTTLIEQLITKMGLREEPNVLEKTTELVRLLELRSTNVPLQINEYGKIVLCADLASCMIGIAFDKEQALKLSGLRKSQYLNNKRMFEKLLDLNKLASVNDICVQLGLNEVARKAEELMTLFKGVAATEDMGTDTSHPQYATMAVFQACRLLKKKVSKSKLMPFSNLRPSQFQLLEQQWERMIAKHHKESKVPSSTDMEGKLKENQNENIKGHEAKKAHKPPPEDYEIWKARMLAKAQAKLKELEASQSHMDSQLLEA

Gene
ORC6
Protein
Origin recognition complex subunit 6
Organism
Bos taurus
Length
252 amino acids
Function
Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication (By similarity).
Similarity
Belongs to the ORC6 family.
Mass
28.08 kDa
Sequence
MESGLIRRLAPRLGIAEQEVLRKAEEYLRLSRVKCVGLSARTTETSNAVMCLDLAASCMKCPLDRAYLIKLSGLNKKMYQSCLKSFECLLGLNSNIGIRDLAVQFSCTEAVNLASKILQSYESSLPQTQQVDLDLSRPLFTTAALLSACKILKLKVDRNKMAATSGVKKAIFDRLCKQLEKIGQQIDREAGDSVTPPQKKKKTVIEPSAKEIENVVETLPKPQKDEDLTQDYEEWKRNILENAARAQKAATQ

Gene
ORC6
Protein
Origin recognition complex subunit 6
Organism
Homo sapiens
Length
252 amino acids
Function
Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. Does not bind histone H3 and H4 trimethylation marks H3K9me3, H3K27me3 and H4K20me3.
Similarity
Belongs to the ORC6 family.
Mass
28.107 kDa
Sequence
MGSELIGRLAPRLGLAEPDMLRKAEEYLRLSRVKCVGLSARTTETSSAVMCLDLAASWMKCPLDRAYLIKLSGLNKETYQSCLKSFECLLGLNSNIGIRDLAVQFSCIEAVNMASKILKSYESSLPQTQQVDLDLSRPLFTSAALLSACKILKLKVDKNKMVATSGVKKAIFDRLCKQLEKIGQQVDREPGDVATPPRKRKKIVVEAPAKEMEKVEEMPHKPQKDEDLTQDYEEWKRKILENAASAQKATAE