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oma-2

Gene
oma-2
Protein
CCCH-type zinc finger protein oma-2
Organism
Caenorhabditis elegans
Length
393 amino acids
Function
Zinc-finger RNA-binding protein that binds to 5'-UA[AU]-3' motifs in the 3'-UTR of maternal mRNAs to suppress translation in oocytes and embryos (PubMed:18417623). Acts redundantly with oma-1 to control the temporal expression and distribution of maternal proteins and thereby promote meiotic progression, oocyte maturation, fertilization and embryonic development (PubMed:11702779, PubMed:12296824, PubMed:12781695, PubMed:16289132, PubMed:16611242, PubMed:18854162, PubMed:18417623, PubMed:19786575, PubMed:20826530, PubMed:25261697). Also, together with oma-1, is involved in P-granule distribution during embryonic development (PubMed:16611242).
Mass
43.585 kDa
Sequence
MDMLKENVIQNNEARTESSVEPSHPDMMETVPEEQQKPISHIDDLLSETANLMAVKEQLLKEIAENEHIHSMQMRALQNLPQEAILPLQYHADPRRRHRMQKPESYKTVICQAWLESKTCAFAENCRFAHGEEELRPSLIEARQNNKYRTKLCDKYTTTGLCPYGKRCLFIHPDNGPNAYIRADKLFEVSQRHALADLRDQMEHHIMNGGRSTAGPQQFDMFARPCTPDEPAANMPLGPTPVSIRGPRYELPSKKPLETEEAGNRPPSSWPLDPSTFFALDSLNMATRPISPFESMLIGAAGNMQYSMLGKQSTPGGVSGYSSSGSTPSQDSDSSPLTAASAAADAACQANSESAQSILLKSINNPMIGNETTLPIPGLDQLAMDIAKHLELW