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oleW

Gene
oleW
Protein
dTDP-3,4-didehydro-2,6-dideoxy-alpha-D-glucose 3-reductase
Organism
Streptomyces antibioticus
Length
328 amino acids
Function
Involved in the biosynthesis of one of the two 2,6-deoxysugars, dTDP-L-oleandrose, attached to the macrolactone ring oleandolide to produce the aglycone antibiotic oleandomycin (Ref.1, PubMed:10770761). Catalyzes the reduction of the C-3 keto moiety of dTDP-3,4-diketo-2,6-dideoxy-alpha-D-glucose to yield dTDP-4-keto-2,6-dideoxy-alpha-D-glucose (Ref.1). NADPH is the better reductant, however NADH can also be used (Ref.1).
Similarity
Belongs to the Gfo/Idh/MocA family.
Mass
35.835 kDa
Sequence
MPSPRLRFGVLGAADIALRRTVPALLAHPDVTVVAVSSRDTARAARFAAAFGCEAVPGHQALLDRDDIDALYVPLPVMVHTPWVEAALLRGRHVLVEKPLTATRSGAEDLIALARSRGLVLMENFTSLHHAQHGTVTDLLRDGTIGELRSLSAAFTIPPKPEGDIRYQPDVGGGALLDIGIYPLRAALHFLGPDLHAAGAVLRRERRRNVVVSGHVLLTTPHGVVAELAFGMEHAYRSEYTLFGTAGRLRLDRAFTPPETHRPRVEIHRQDALDIVDLPPDAQFANLVRDFVLAVREGPGRLTQHHADAVRQADLVERVMAVARVRWC