Function
Involved in the biosynthesis of one of the two 2,6-deoxysugars, dTDP-L-oleandrose, attached to the macrolactone ring oleandolide to produce the aglycone antibiotic oleandomycin (Ref.1, PubMed:10770761). Catalyzes the reduction of the C-3 keto moiety of dTDP-3,4-diketo-2,6-dideoxy-alpha-D-glucose to yield dTDP-4-keto-2,6-dideoxy-alpha-D-glucose (Ref.1). NADPH is the better reductant, however NADH can also be used (Ref.1).
Sequence
MPSPRLRFGVLGAADIALRRTVPALLAHPDVTVVAVSSRDTARAARFAAAFGCEAVPGHQALLDRDDIDALYVPLPVMVHTPWVEAALLRGRHVLVEKPLTATRSGAEDLIALARSRGLVLMENFTSLHHAQHGTVTDLLRDGTIGELRSLSAAFTIPPKPEGDIRYQPDVGGGALLDIGIYPLRAALHFLGPDLHAAGAVLRRERRRNVVVSGHVLLTTPHGVVAELAFGMEHAYRSEYTLFGTAGRLRLDRAFTPPETHRPRVEIHRQDALDIVDLPPDAQFANLVRDFVLAVREGPGRLTQHHADAVRQADLVERVMAVARVRWC