Protein
Probable dTDP-4,6-dihydroxy-2-methyloxan-3-one 4-ketoreductase
Organism
Streptomyces antibioticus
Function
Involved in the biosynthesis of one of the two 2,6-deoxysugars, dTDP-L-oleandrose, attached to the macrolactone ring oleandolide to produce the aglycone antibiotic oleandomycin (PubMed:10770761). Probably catalyzes the reduction of dTDP-4-keto-2,6-dideoxy-beta-L-galactose to yield dTDP-L-olivose.
Similarity
Belongs to the dTDP-4-dehydrorhamnose reductase family.
Sequence
MRWLITGAAGMLGRELVRRLAENEEDVAALGHDHLDVTRPSAVRAALAEHRPGIVVNCAAYTAVDDAETDEAAAALLNAEAPRLLAEGLRPHRRHGLVHLSTDYVFPGDARTPYAEDHPTAPRSAYGRTKRDGEQAVLTALPTATVLRTAWLYGRTGRSFVRTMIEREARGGAIDVVADQRGQPTWTGDLADRIIAVGRHPGVHGILHATNAGSATWYDLAQEVFRLLDADPGRVRPTTGAAFRRPAPRPAYSVLGHDRWRGTGLAPLRDWRSALREAFPDILAAEHPPTRRGAA