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oleU

Gene
oleU
Protein
Probable dTDP-4,6-dihydroxy-2-methyloxan-3-one 4-ketoreductase
Organism
Streptomyces antibioticus
Length
295 amino acids
Function
Involved in the biosynthesis of one of the two 2,6-deoxysugars, dTDP-L-oleandrose, attached to the macrolactone ring oleandolide to produce the aglycone antibiotic oleandomycin (PubMed:10770761). Probably catalyzes the reduction of dTDP-4-keto-2,6-dideoxy-beta-L-galactose to yield dTDP-L-olivose.
Similarity
Belongs to the dTDP-4-dehydrorhamnose reductase family.
Mass
32.099 kDa
Sequence
MRWLITGAAGMLGRELVRRLAENEEDVAALGHDHLDVTRPSAVRAALAEHRPGIVVNCAAYTAVDDAETDEAAAALLNAEAPRLLAEGLRPHRRHGLVHLSTDYVFPGDARTPYAEDHPTAPRSAYGRTKRDGEQAVLTALPTATVLRTAWLYGRTGRSFVRTMIEREARGGAIDVVADQRGQPTWTGDLADRIIAVGRHPGVHGILHATNAGSATWYDLAQEVFRLLDADPGRVRPTTGAAFRRPAPRPAYSVLGHDRWRGTGLAPLRDWRSALREAFPDILAAEHPPTRRGAA