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oaz-1

Gene
oaz-1
Protein
Ornithine decarboxylase antizyme
Organism
Caenorhabditis elegans
Length
159 amino acids
Function
Ornithine decarboxylase (ODC) antizyme protein that negatively regulates ODC activity and intracellular polyamine biosynthesis and uptake in response to increased intracellular polyamine levels. Binds to ODC monomers, inhibiting the assembly of the functional ODC homodimer, and targets the monomers for ubiquitin-independent proteolytic destruction by the 26S proteasome.
Similarity
Belongs to the ODC antizyme family.
Mass
17.71 kDa
Sequence
MSSILSSNFTNKSNQLVNESAVDSSLTASPCSTQPGDVGWCFDAPHGVLTKLPNETRAIVSAVSPNWRVTSIGEKTLAIMIPHDQPVLGISKKNFVDLLEFAEDKLEMERVLAVFEKARINPTEGFPRTLRYVGFRPYAIDEHPVHLPAEKYFIMSYKV