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nurA

Gene
nurA
Protein
DNA double-strand break repair nuclease NurA
Organism
Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)
Length
451 amino acids
Function
Involved in DNA double-strand break (DSB) repair (PubMed:18957200). Acts probably with HerA to stimulate resection of the 5' strand and produce the long 3' single-strand that is required for RadA loading (PubMed:18957200). Exhibits 5' endonuclease activity and both 5' and 3' exonuclease activities (PubMed:22064858).
Similarity
Belongs to the NurA family.
Mass
51.609 kDa
Sequence
MRLLSKQSIERITKILLDELENVRENEQIRNIINSWKPLPSPEKSSIYAVDGSRSVSRLSGTVIYFLSALAVGSGKQLRLSYANAIKSNYGTSDQIVRMQMETLENMLGYLAYRKLEGEKRAILMDGTLTGSLVRPPVYPEDIRSLNVMRALIGESDFENLLNEFLEKLRDHYRKVEEHLEKNGNYDSPILTDNVVEKLRKKYIDTKVIAYGSGKVKVKIPRKALGYSPRVIPIEVLESSRGKSVDELLQELDEEKVELYLGKDDIYDALHMTLSYIEYLYSIDKLLEVKNLAYIAKSFYTKTLARTLGVEIVDTALLDAVIRTLIGHEKEGYLEIEHAVVPPKWSFPDFLLSKFRNIEKLIDKGIHLAYVRFEQGDVIYMLQSTTNIEKILPLILHHKAGGYLRPLQLAHHGVKISYKEARHTLEALINALRNRDPALKIFVKYGRSPLE

Gene
nurA
Protein
Probable DNA double-strand break repair nuclease NurA
Organism
Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)
Length
389 amino acids
Function
Involved in DNA double-strand break (DSB) repair (By similarity). Acts probably with HerA to stimulate resection of the 5' strand and produce the long 3' single-strand that is required for RadA loading (By similarity).
Similarity
Belongs to the NurA family.
Mass
45.314 kDa
Sequence
MFFKIFVENTVILPNPLILTKIEGLLMIEYLLKNREQIIKKMEKINDINRKEVEEKWILDNFENPKDMGFAGGDGSCNKLDYISFSFYGVGAVSFIHGRGEKVKKAKEEYIFDITHPLDIEDRIRRYMLTLELKTALYVLKNYNIDYYIFDGSLFSLLIFTKKGIEMYERELEEIYNEYGKEFNKKIDEETKSGEIGIISKDLNLELNKKILVEHVEYILTLTKLINEFKDRIIGISKTSKINIYFDKNMPDIAIFTKYTDKSGYSEPIDFVNKLGDEKKEKHKQLSSVVKGINFIKNKPFYAKIDTAYIQFVRLEDNCGVVGLTSFNKIDKEVLSSLKEISINGYPYILKKSHETVEITTKKLEAIAKLLNIDDPIARHILGKKKKKF

Gene
nurA
Protein
DNA double-strand break repair nuclease NurA
Organism
Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
Length
339 amino acids
Function
Involved in DNA double-strand break (DSB) repair (PubMed:22135300). Acts probably with HerA to stimulate resection of the 5' strand and produce the long 3' single-strand that is required for RadA loading (By similarity). Processes linear dsDNA probes with 3' or 5' single-stranded overhangs or blunt ends (PubMed:22135300).
Similarity
Belongs to the NurA family.
Mass
39.125 kDa
Sequence
MIRKIYDKLVESHNEIKNQIYNIANYLKQEIQDKVNEYWNEYVINHEQSETCKFVAIDGGSFGRPMRIGIVYAVGAESVIGDNKGVKTLSEDGQIGIFKPGNDAQERISLLMEALELSLALRDGSKGDYILMDGSLSKKIGNKVDIQQFSDEELKLIRNVDLNGIISIKDERKMRDLLMLLNQFLVSKIIEEYDGNVLWISKVSRGRDLFGTDYPDITVLELFTEKRGFSKLIIKNIDIEKISEIPEIEVLRKMEYTTFYTRLDNGKRVIRVDIVGRVDEKIVKEIMDRLSGVSIKGYPFPLLKAHMDVRFSAMDREKIIKLVGSKLHKDIEWWPSQFY

Gene
nurA
Protein
DNA double-strand break repair nuclease NurA
Organism
Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770)
Length
332 amino acids
Function
Involved in DNA double-strand break (DSB) repair (PubMed:12052775). Acts probably with HerA to stimulate resection of the 5' strand and produce the long 3' single-strand that is required for RadA loading (By similarity). Exhibits both single-stranded endonuclease activity and 5'-3' exonuclease activity on single-stranded and double-stranded DNA (PubMed:12052775).
Similarity
Belongs to the NurA family.
Mass
38.888 kDa
Sequence
MIDKAYEELIKMKEKIMRDSYTIHKELSESVESILNELWINYSPESVEHSKKLLAIDGGMWVKETRQGVIFIVNAKAIVFEGINEINSEGKVLVHIFSPGNYAKERIELLMQLLELQLALKLVENVDYVLLDGSFSKKLGRHKSELKVDLLDDIVSIDKILSLEEKDEDNMLRFLIAENQLVLSELVSRYKDKLLFISKNSKSSDLFKQAYSDITILELFTQNCGYSKILEKKIDENYILSRKASKLLSGLNYYFTNLRLEPSERLFRLDFFNADKIFEYLKVLKPVSLKGYPYPLIKVHKDVRVGKEDRERIYSILEMKRKDISWWPSQFY

Gene
nurA
Protein
DNA double-strand break repair nuclease NurA
Organism
Sulfurisphaera tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7)
Length
331 amino acids
Function
Involved in DNA double-strand break (DSB) repair (By similarity). Acts probably with HerA to stimulate resection of the 5' strand and produce the long 3' single-strand that is required for RadA loading (By similarity). Exhibits both single-stranded endonuclease activity and 5'-3' exonuclease activity on single-stranded and double-stranded DNA (PubMed:18194801).
Similarity
Belongs to the NurA family.
Mass
38.016 kDa
Sequence
MIKDVYELLLSRKNEIEKQISLLDETSNNLLKEKIKEKWKEYCQTQGKLSTVLAIDGGMWIKELRSGIVYIVNAEIVKAEGFNVTPIDSKALIGVLRPGNMAKERVSLLMQLLELKLGLKHGDKAEYILFDGSIVKKIGKHKFSTKISLLDDIDVMDDKIYSLEENDEELMHKYLVAENQLVMSALISKYKGKLVWISKNSKSTELFQENISDVSLLELFTKNCGYTIGIEKKISSENIISPKASTILSNASFYSFYTRLKEGEKILKIEMFNNEIENIISILSPISIKGYPYPLLKVHTDVKVSRQDRERIKQLLNIKKKDIEWWPSQLF